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Author Khabarov, V. N
Title Hyaluronic Acid : Production, Properties, Application in Biology and Medicine
Imprint New York : John Wiley & Sons, Incorporated, 2015
©2014
book jacket
Edition 1st ed
Descript 1 online resource (215 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Intro -- Title Page -- Copyright Page -- Contents -- Foreword -- Introduction -- Chapter 1 The History of Hyaluronic Acid Discovery, Foundational Research and Initial Use -- 1.1 Discovery -- 1.2 Foundational Research -- 1.3 Initial Medical Applications -- 1.4 Sources of Hyaluronan -- 1.5 Current Medical Study and Use -- 1.6 Impact and Future Directions -- References -- Chapter 2 The Biological Role of Hyaluronic Acid -- 2.1 Hyaluronic Acid Phylogenesis -- 2.1.1 Polysaccharide Structure and the Problems of Phylogenesis -- 2.1.2 Physico-Chemical and Functional Differences of Polysaccharides -- 2.1.3 Biochemical Features of Hyaluronic Acid and Other Glycosaminoglycans -- 2.2 Functions of Hyaluronan in Human Ontogenesis -- 2.2.1 Role of Hyaluronic Acid in Fertilization -- 2.2.2 Hyaluronan and Other Glucosaminoglycans in Cell Division, Migration and Differentiation -- 2.2.3 Hyaluronic Acid and Sulfated Glycosaminoglycans in Maintaining a Differentiated Status of Cells -- 2.2.4 Hyaluronan and Induction of Cellular Cycles for Differentiated Cells -- 2.2.5 The Source of Hyaluronic Acid's Functional Properties and the Dynamics of its Synthesis and Degradation -- 2.2.6 The Rules of Biopolymer Functional Cleavage -- 2.3 Hyaluronan Signalling Systems -- 2.4 Hyaluronan Functions in the Extracellular Matrix -- 2.4.1 Extracellular Space -- 2.4.2 Composition and Functioning of the Extracellular Matrix -- 2.4.3 The Role of Hyaluronan in Transportation of Substances through the Extracellular Matrix: Diffusion, Osmosis, Electro-Osmosis and Vesicular Transportation -- 2.4.4 Hyaluronan in the Extracellular Matrix of Different Connective Tissues -- References -- Chapter 3 Methods of Hyaluronic Acid Production -- 3.1 Hyaluronan Sources and Extraction -- 3.1.1 Hyaluronan Production from Animal Sources: General Methods -- 3.1.2 Hyaluronan Purification
3.1.3 The Chemical Production of Hyaluronan from Chicken Combs -- 3.1.4 HA Production for Ophthalmology -- 3.2 Bacterial Methods of Hyaluronic Acid Production -- 3.3 Hyaluronan Destruction during Production, Storage and Sterilization -- 3.4 Enzymatic Destruction of Hyaluronan -- 3.4.1 Hyaluronidase Classification -- 3.4.2 Properties and Functions of Hyaluronidases -- 3.5 Non-Enzymatic Destruction of Hyaluronan -- 3.5.1 Acid-Base Hydrolysis of Hyaluronan -- 3.5.2 Oxidation-Reduction Depolymerization of Hyaluronan -- 3.6 Quality of Hyaluronan Commercial Products of Animal and Bacterial Origin -- References -- Chapter 4 Molecular and Supramolecular Structure of Hyaluronic Acid -- 4.1 Primary Structure of Hyaluronic Acid -- 4.2 Structure of Hyaluronan in Solution -- 4.3 Rheological Properties of Hyaluronic Acid -- References -- Chapter 5 Chemical Modifications, Solid Phase, Radio-Chemical and Enzymatic Transformations of Hyaluronic Acid -- 5.1 Main Characteristics of Cross-Linked Hydrogels -- 5.2 Methods of Hyaluronic Acid Cross-Linking -- 5.2.1 Cross-Linking with Carbodiimides -- 5.2.2 Cross-Linking with Aldehydes -- 5.2.3 Cross-Linking with Divinylsulfone -- 5.2.4 Cross-Linking by the Ions of Polyvalent Metals -- 5.2.5 Cross-Linking with Epoxides -- 5.2.6 Photo-Cross-Linking -- 5.2.7 Solid-State Cross-Linking under High Pressure and Shear Deformation (Solid-State Reactive Blending: SSRB) -- 5.3 Radiochemical Transformations (Radiolysis) of Hyaluronan Aqueous Solutions -- References -- Chapter 6 Medical Applications of Hyaluronan -- 6.1 Hyaluronan and Aesthetic Medicine -- 6.1.1 Intradermal Hyaluronan-Based Microimplants -- 6.1.2 Cross-Linking of Hyaluronan into a Three-Dimensional Network -- 6.1.3 Hyaluronic Acid in Injection Cosmetology (Biorevitalization) -- 6.1.4 Molecular Weight of Hyaluronan in Biorevitalization Products
6.1.5 Antioxidant Efficiency of Hyaluronan and other Biologically Active Compounds as Potential Products for Aesthetic Medicine -- 6.1.6 Bio-Repairants as a New Class of Injectable Products Based on Hyaluronic Acid Modified with Low Molecular Weight Bio-Regulators -- 6.2 Hyaluronan in Arthrology -- 6.3 Hyaluronan in Ophthalmology -- 6.4 Hyaluronan in Oncology -- 6.5 The Role of Hyaluronan in Healing Wounds -- 6.6 Hyaluronan in Immunology -- References -- Conclusion -- Index -- EULA
Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and contributes to cell proliferation and migration. It is used as a stimulating agent for collagen synthesis and is a common ingredient in skin-care products, a multi-billion dollar industry, as it is believed to be a key factor in fighting the aging process. Hyaluronic Acid: Production, Properties, Application in Biology and Medicine consists of six chapters discussing the various issues of hyaluronic acid research. In Chapter 1, a historical analysis recounts the discovery and milestones of the research leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid in nature, in particular in the human body. The chapter starts from the phylogenesis of hyaluronic acid, then describes hyaluronan functions in human ontogenesis and especially the role which hyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purify hyaluronic acid, including the analytical means for assessing quality of the finished product. Chapter 4 discusses the structure and rheological properties of hyaluronic acid considering effects on conformation and biological properties related to molecular weight. In Chapter 5, the physical and chemical methods for modifying the structure of hyaluronan are discussed including cross-linking using bi-functional reagents, solid-phase modification and effects of the combined action of high pressures and shift deformation. The final chapter focuses on the products derived from hyaluronic acid, including therapeutics composed of modified hyaluronan conjugated to vitamins, amino acids and oligo-peptides. The biological roles and medical applications of this polysaccharide have been extensively studied and this book provides a wealth of
scientific data demonstrating the critical role of hyaluronic acid and its promise as a multifaceted bio-macromolecule. Approaching hyaluronic acid from multiple angles, this book links relationships between its biological functions, structure and physical-chemical properties. It will be an invaluable resource to researchers, both industrial and academic, involved in all aspects of hyaluronan-based technologies
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Khabarov, V. N. Hyaluronic Acid : Production, Properties, Application in Biology and Medicine New York : John Wiley & Sons, Incorporated,c2015 9781118633793
Subject Hyaluronic acid.;Organic acids
Electronic books
Alt Author Boykov, P. Y
Selyanin, M. A
Polyak, Felix
Polyak, Felix
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