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Author Shaw, Paul
Title The Genetic Basis of Sleep and Sleep Disorders
Imprint New York : Cambridge University Press, 2013
book jacket
Descript 1 online resource (436 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Intro -- Contents -- Foreword -- Preface -- Contributors -- Abbreviations -- Section 1 General principles of genetics and genomics -- Chapter 1 Linkage and associations -- Introduction -- Linkage -- Linkage results in narcolepsy-cataplexy -- Linkage results in familial advanced sleep phase syndrome (FASPS) -- Linkage results in restless leg syndrome -- Complex phenotypes -- Methodology in studying complex phenotypes -- Genome-wide association studies in sleep and sleep-related disorders -- Sleep diseases as dichotomous traits -- Sleep as a quantitative trait -- Conclusion -- References -- Chapter 2 Methods in complex trait analysis: mapping the genetic basis of sleep using model organisms -- Introduction -- Inbred strains -- Genetic mapping using crosses between inbred strains -- Genetic mapping without genotyping: recombinant inbreds and the collaborative cross -- Genetic mapping without genotyping: recombinant congenics and consomics -- Genetic mapping without genotyping: in silico mapping -- Genetic mapping without genotyping: the hybrid mouse diversity panel -- High-resolution mapping and gene identification: congenics, AILs, and outbreds -- Sequencing -- A wealth of choice -- References -- Chapter 3 Genome-wide association study (GWAS) approaches to sleep phenotypes -- Introduction -- Genes associated with sleep-wake regulation -- Genetics of sleep disorders -- Restless legs syndrome -- Narcolepsy -- Insomnia -- Sleep apnea -- Conclusions -- References -- Section 2 Genetics of sleep and circadian rhythms -- Chapter 4 Genetic epidemiology of sleep and sleep disorders -- Introduction -- Methods in genetic epidemiology -- Normal sleep -- Sleep electroencephalogram (EEG) and polysomnography (PSG) -- Diurnal type -- Sleep length -- Sleep quality -- Abnormal sleep, sleepiness and sleep disorders -- Insufficient sleep -- Daytime sleepiness
Sleep problems -- Insomnia -- Obstructive sleep apnea (OSA) -- Narcolepsy -- Parasomnias -- Arousal disorders -- Sleep-wake transition disorders -- Parasomnias usually associated with REM sleep -- Other parasomnias -- Is there a common genetic basis to parasomnia? -- Restless legs syndrome (RLS) -- Conclusions -- References -- Chapter 5 Drosophila model systems for genetic sleep research -- In the beginning: using a candidate gene approach for studying sleep in Drosophila -- Interpreting results from genetic studies -- Short-term memory -- Long-term memory -- Unbiased screens -- Circuits regulating sleep in Drosophila -- Mushroom bodies -- Pars intercerebralis -- Ventral lateral neurons -- Octopamine-expressing neurons -- Dorsal fan-shaped body -- Dopamine-expressing neurons -- Forward genetic screens -- Mutant screens -- Minisleep and Shaker -- Sleepless -- Insomniac -- Cyclin A -- Plasticity -- Summary -- References -- Chapter 6 Caenorhabditis elegans and zebrafish in sleep research -- Behavioral approach to identify and study sleep -- Zebrafish sleep -- Behavior -- Anatomy -- Pharmacology -- Genetics -- C. elegans sleep -- C. elegans sleep genetics -- Mechanism of sensory gating during sleep in C. elegans -- The future -- Discovery genetics and screens -- Physiological activity during sleep -- Optogenetic manipulation of the sleep neural circuit -- Exploring sleep function -- Cavefish sleep -- References -- Chapter 7 Optogenetic control of arousal neurons -- Hypocretins, narcolepsy and wakefulness -- The locus coeruleus, norepinephrine and arousal -- Optogenetic dissection of Hcrt and LC-NE control of arousal -- Hcrt and LC-NE system dynamics -- Perspectives -- Acknowledgments -- References -- Chapter 8 Prostaglandin D2 in the regulation of sleep -- Introduction -- PGD2 induces sleep -- PGD2 synthase and receptors in the CNS
The molecular mechanisms of sleep induction by PGD2 -- Sleep in L-PGDS, DP1, and A2A receptor KO mice -- Relevance of PGD2 in physiological sleep -- Other roles of adenosine in sleep regulation -- The PGD2/adenosine system and human sleep -- Conclusions and future studies -- References -- Chapter 9 Astroglial regulation of sleep -- Introduction -- Signaling in glial cells: slow and steady? -- Early concepts of glial roles in sleep -- Glia, neural metabolism and sleep -- Ion buffering and electroencephalographic (EEG) activity -- Glial secretion of somnogenic substances: astrocytes -- Glial secretion of somnogenic substances: microglia and oligodendrocytes -- Unanswered questions and future directions -- References -- Chapter 10 The role of metabolic genes in sleep regulation -- Early metabolic hypotheses -- Metabolic endocrine system as a regulator of sleep -- Transcriptional differences between sleep and wake -- Energy metabolism enzymes regulate sleep and the response to sleep deprivation -- Non-metabolic genes affecting both metabolism and sleep regulation -- Conclusion -- References -- Chapter 11 A systems biology approach for uncovering the genetic landscape for multiple sleep-wake traits -- Summary -- Introduction -- Single-gene approaches -- The QTL approach -- Systems genetics approaches -- Conclusions and future directions -- Acknowledgment -- References -- Chapter 12 Genetic control of the circadian pacemaker -- The molecular circadian CLOCK in mammals -- Paralogs: similar, but different -- CLOCK-controlled genome-wide transcription -- Input mechanisms -- Non-transcriptional rhythms -- Conclusions -- References -- Chapter 13 Epigenetic basis of circadian rhythms and sleep disorders -- Introduction -- Epigenetic mechanisms and factors -- DNA cytosine methylation and hydroxymethylation
Histone post-translational modifications and higher-order chromatin remodeling -- Non-coding RNA regulation -- RNA editing -- Genomic imprinting -- Emerging links between epigenetics and circadian rhythms and sleep -- DNA methylation -- Histone modifications and chromatin remodeling -- Non-coding RNAs -- RNA editing -- Genomic imprinting -- Epigenetics of human sleep-wake disorders -- Perspectives -- Acknowledgments -- References -- Section 3 Sleep physiology and homeostasis -- Chapter 14 Genetics of sleep and EEG -- Introduction -- Genetics of the EEG in humans -- Twin studies -- Family studies -- Genetics of sleep in humans -- Genetics of sleep in mice -- Candidate gene approach -- Quantitative trait locus (QTL) analysis -- Gene expression and sleep -- Conclusion -- References -- Chapter 15 Genetic interaction between circadian and homeostatic regulation of sleep -- Introduction -- Background -- Markers of sleep homeostasis and their heritability -- Sleep timing and variations in sleep homeostasis dynamics -- Sleep homeostasis and synaptic function -- The circadian timing system and its molecular components -- Interaction and independence of sleep regulatory processes -- Elevated sleep pressure modifies the expression of clock genes -- Clock gene mutations impact on the dynamics of sleep homeostasis -- Clock genes: regulators of synaptic elements? -- Conclusion -- Acknowledgments -- References -- Chapter 16 Genetic approaches to understanding circadian entrainment -- Introduction -- The circadian clock in model organisms -- Understanding the genetics of circadian entrainment in humans -- The phenotype (time-of-day preference vs. chronotype) -- The circadian phenotype genetics in humans -- Familial syndromes -- Association studies in the general population -- Dissecting the genetic complexity -- Gene-environment interactions -- Concluding remarks
References -- Chapter 17 Animal models for cognitive deficits induced by sleep deprivation -- Introduction -- Rodent models -- Sleep deprivation protocols in rodents -- Cognitive tasks used in rodent sleep deprivation studies -- Avoidance tasks and fear conditioning tests -- Spatial maze tests -- Other tests -- Effect of sleep restriction on cognition -- Impact of sleep deprivation preceding learning -- Impact of sleep deprivation on memory consolidation -- Sleep and replay of neuronal activity -- Potential mechanisms involved in sleep deprivation-induced cognitive impairments -- Hippocampus and the modulation of glutamate receptors -- Adenosine -- Synaptic strengthening -- Bird models -- Sleep deprivation in avian models -- Song learning -- Imprinting -- Auditory discrimination -- Maintenance of cognitive function during migration -- The Drosophila model -- Sleep deprivation methods in Drosophila -- The aversive phototactic suppression (APS) assay -- Molecular pathways involved in APS learning impairments -- Dopamine signalling -- Notch signalling -- Lipid storage droplet 2 (Lsd2) and free fatty acid metabolism -- Foraging alleles -- Other Drosophila paradigms used to investigate cognitive deficits induced by sleep loss -- Olfactory conditioning -- Courtship conditioning -- Conclusion -- References -- Chapter 18 Individual differences in sleep duration and responses to sleep loss -- Introduction: sleep regulation -- Individual differences in sleep duration -- Role of prior sleep history -- Allostatic changes to sleep homeostasis -- Sleep duration as a neurobiological trait -- Differential vulnerability to sleep loss -- Genetic underpinnings of differential vulnerability to sleep loss -- Conclusion -- Acknowledgments -- References -- Chapter 19 Clock polymorphisms associated with human diurnal preference -- Introduction
Measurement of diurnal preference
The first comprehensive and up-to-date book to cover genetics and genetic techniques in the study of sleep and sleep disorders
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Shaw, Paul The Genetic Basis of Sleep and Sleep Disorders New York : Cambridge University Press,c2013 9781107041257
Subject Sleep.;Sleep disorders.;Genetics
Electronic books
Alt Author Tafti, Mehdi
Thorpy, Michael J
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