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Author Simon, Richard M
Title Genomic Clinical Trials and Predictive Medicine
Imprint New York : Cambridge University Press, 2013
©2013
book jacket
Descript 1 online resource (160 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Practical Guides to Biostatistics and Epidemiology
Practical Guides to Biostatistics and Epidemiology
Note Intro -- Contents -- Acknowledgments -- Introduction -- 1 Clinical Trial Basics -- 2 Actionable Prognostic Biomarkers -- 2.1 Design and Analysis of Developmental Studies of Prognostic Classifiers -- 2.1.1 Sample Size Planning -- 2.1.2 Clinical Validation -- 2.2 Design of Validation Studies of Prognostic Classifiers -- 3 Phase II Designs -- 4 Enrichment Designs -- 5 Including Both Test-Positive and Test-Negative Patients -- 5.1 Interaction Tests -- 5.2 Probabilistic Indication Classifier -- 5.3 Planning Sample Size -- 5.4 Adaptively Modifying Types of Patients Accrued -- 6 Adaptive Threshold Design -- 6.1 Sample Size Planning -- 7 Multiple Predictive Biomarkers -- 7.1 Designs Based on Few Candidate Biomarkers -- 7.2 Designs for Development and Validation of Multivariate Classifiers -- 7.2.1 Predictive Classifiers -- 7.2.2 Probabilistic Predictive Classifier -- 7.2.3 Adaptive Signature Design -- 7.2.4 Cross-Validated Adaptive Signature Design - Predictive Analysis of Clinical Trials -- 8 Prospective-Retrospective Design -- 8.1 Levels of Evidence -- Appendix A Statistics Background -- A.1 Statistical Significance -- A.2 Confidence Interval -- A.3 Statistical Power -- A.4 Survival Data -- A.5 Linear Regression -- A.6 Logistic Regression -- A.7 Proportional Hazards Regression -- A.8 Bayesian Methods -- Appendix B Prognostic Classifiers Based on High-Dimensional Data -- B.1 The Development of Classifiers -- B.2 Components of Class Prediction -- B.3 Estimating the Accuracy of a Class Predictor -- B.4 Class Prediction Algorithms -- B.4.1 Feature Selection -- B.4.2 Classifier Types -- B.5 Probabilistic Class Prediction -- B.6 Survival Risk Prediction -- B.6.1 Survival Risk Classifiers -- B.6.2 Cross-Validated Kaplan-Meier Curves -- B.6.3 Time-Dependent Receiver Operating Characteristic Curves
B.7 Evaluating Whether a Prognostic Classifier Improves on Existing Prognostic Factors -- References -- Index
This book focuses on novel approaches that provide a reliable basis for identifying what kinds of patients are likely to benefit from the each new treatment
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Simon, Richard M. Genomic Clinical Trials and Predictive Medicine New York : Cambridge University Press,c2013 9781107008809
Subject Genomics -- Statistical methods.;Clinical trials.;Medicine, Preventive
Electronic books
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