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Author Teutenberg, Thorsten
Title High-Temperature Liquid Chromatography : A User's Guide for Method Development
Imprint Cambridge : Royal Society of Chemistry, 2010
©2010
book jacket
Edition 1st ed
Descript 1 online resource (221 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series ISSN ; v.13
ISSN
Note High-Temperature Liquid Chromatography -- Contents -- Chapter 1 A Brief Definition of High-Temperature Liquid Chromatography -- 1.1 What is High-Temperature Liquid Chromatography? -- 1.2 What is a Suitable Temperature Range for High-Temperature Liquid Chromatography? -- 1.3 Why should High Temperatures be used in Liquid Chromatography? -- 1.4 What are the Principal Requirements of High-Temperature Liquid Chromatography? -- Chapter 2 System Set-up for High-Temperature Liquid Chromatography -- 2.1 The Heating System -- 2.2 The Column -- 2.3 The Detector -- 2.4 The Back-Pressure Regulator -- Chapter 3 The Heating System -- 3.1 Preheating of the Mobile Phase -- 3.1.1 Thermal Mismatch Broadening -- 3.1.2 Viscous Heat Dissipation -- 3.1.3 Technical Implementation of Eluent Preheating -- 3.1.4 Experimental Verification of Eluent Preheating Efficiency -- 3.2 Column Heating -- 3.2.1 Air-Bath Ovens -- 3.2.2 Water-Jacket Ovens -- 3.2.3 Block-Heating Ovens -- 3.3 Post-Column Cooling of the Mobile Phase -- 3.4 Temperature Programming -- 3.5 A Critical Comparison between Different Ovens -- 3.5.1 Air-Bath Ovens -- 3.5.2 Water-Jacket Ovens -- 3.5.3 Block-Heating Ovens -- 3.5.4 Summary -- Chapter 4 Mobile Phase Considerations -- 4.1 Influence of Temperature on Vapour Pressure -- 4.1.1 Prevention of a Phase Transition using a Back-Pressure Regulator -- 4.1.2 Prevention of a Phase Transition using a Restriction Capillary -- 4.2 Influence of Temperature on Viscosity -- 4.2.1 Practical Implications - The Restriction Capillary -- 4.2.2 Practical Implications - Kinetic Aspects and Column Pressure -- 4.3 Influence of Temperature on Static Permittivity -- 4.4 The Water-THF System -- 4.5 The Dortmund Data Bank -- Chapter 5 Suitable Stationary Phases -- 5.1 Column Bleed -- 5.2 Investigation of Column Degradation at High Temperatures -- 5.3 Silica-Based Stationary Phases
5.4 Zirconium Dioxide Stationary Phases -- 5.5 Titanium Dioxide Stationary Phases -- 5.6 Polymeric Stationary Phases -- 5.7 Other Materials -- 5.7.1 Graphitized Carbon Column -- 5.7.2 Thermo-Responsive Stationary Phases -- 5.8 General Conclusions -- Chapter 6 Method Development using Temperature as an Active Variable -- 6.1 Special Requirements of the Heating System -- 6.2 Special Requirements of the Column Hardware -- 6.3 Mobile Phase Considerations -- 6.4 Influence of Temperature on Resolution -- 6.4.1 Influence of Temperature on Retention -- 6.4.2 Influence of Temperature on Selectivity -- 6.4.3 Influence of Temperature on Efficiency -- 6.5 Method Development -- 6.5.1 Isothermal and Isocratic Separations -- 6.5.2 Temperature Gradient and Isocratic Separation -- 6.5.3 Simultaneous Temperature and Solvent Gradient Separation -- 6.5.4 Detector Optimization -- Chapter 7 Analyte Stability -- 7.1 Evaluation of Analyte Stability using UV Detection -- 7.2 Influence of the Stationary Phase on Analyte Stability -- 7.3 Definition of Critical Criteria for Analyte Stability -- Chapter 8 Special Hyphenation Techniques -- 8.1 Flame Ionization Detection -- 8.2 LC-NMR -- 8.3 Isotope Ratio Mass Spectrometry -- 8.4 LC Taste® -- 8.5 Drug Screening -- Chapter 9 Critical Outlook and Future Prospects -- 9.1 Pellicular Particles -- 9.2 Capillary and Nano HPLC -- 9.3 Comprehensive Two-Dimensional Liquid Chromatography -- Appendix A Vapour Pressure Data -- Appendix B Viscosity Data -- Appendix C Static Permittivity Data -- Subject Index
This unique book covers all the practical aspects of setting up an HPLC system for high temperature operation
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Teutenberg, Thorsten High-Temperature Liquid Chromatography : A User's Guide for Method Development Cambridge : Royal Society of Chemistry,c2010 9781849730136
Subject High temperature chemistry
Electronic books
Alt Author Smith, Roger M
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