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Author Vecchione, Severo
Title Acute Lymphoblastic Leukemia : Etiology, Pathogenesis and Treatments
Imprint Hauppauge : Nova Science Publishers, Incorporated, 2012
book jacket
Descript 1 online resource (251 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Cancer Etiology, Diagnosis and Treatments
Cancer Etiology, Diagnosis and Treatments
Note Intro -- ACUTE LYMPHOBLASTIC LEUKEMIA: ETIOLOGY, PATHOGENESIS AND TREATMENTS -- CANCER ETIOLOGY, DIAGNOSIS AND TREATMENTS -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Genome Wide Association Studies in Pediatric Acute Lymphoblastic Leukemia: Pathogenesis and Therapy -- Abstract -- Abbreviations -- Introduction -- Ikaros -- HOX -- FLT3 (fms-Related Tyrosine Kinase 3) -- Notch-1 and FBXW7 (F-Box andWD Repeat Domain Containing) Mutations -- PTEN -- Ras Oncogenes -- Wnt -- Wilms' Tumor Gene 1 (WT1) -- Conclusion -- References -- Mice Deficient for the Slp65 Signaling Protein: A Model for Pre-B Cell Acute Lymphoblastic Leukemia -- Abstract -- Introduction -- Malignancies of Pre-B Cells in Human: Acute Lymphoblastic Leukemia -- Involvement of SLP65 in the Development of B-Lineage ALL in Human -- B Lymphocyte Development in Mouse Bone Marrow -- Ig H Chain Gene Recombination and the Generation of Pre-B Cells -- Pre-B Cells and the Pre-BCR Checkpoint in B Cell Development -- Pre-BCR Signaling Pathways -- Regulation of Pre-B Cell Proliferation -- Progression from Large Cycling into Small Resting Pre-B Cells -- Beyond the Pre-B Cell Stage: Immature and Mature B Cells -- The Germinal Center Reaction -- Mechanism of Malignant Transformation of Slp65-Deficient Pre-B Cells -- Future Directions -- Acknowledgment -- References -- Childhood Acute Lymphoblastic Leukemia -- Abstract -- Introduction -- Etiology of Childhood Acute Lymphoblastic Leukemia -- Prenatal Origin -- Inherited Predisposition -- Environmental Factors -- A Critical Role for Infection? -- Classification of Acute Lymphoblastic Leukemia -- Genetic Aberrations in Childhood Acute Lymphoblastic Leukemia -- Numerical Chromosome Abnormalities -- ALL with Hypodiploidy -- Chromosomal Translocations -- t(12 -- 21)/ TEL-AML1 (ETV6- RUNX1)
Abnormalities Involving 11q23/MLL -- t(1 -- 19)(q23 -- p13) and Pre-B-ALL -- Philadelphia-chromosome Positive ALL -- B Cell ALL and t(8 -- 14)(q24 -- q32) and its Variants -- Tumor Suppressor Genes and Allelic Losses -- Deletions in Cell Cycle Checkpoint Genes/ Abnormalities of the Short Arm of Chromosome 9 -- Acute Lymphoblastic Leukemia in Infancy -- Genetic Changes Associated with T-ALL -- Translocations Involving T Cell Receptors Genes -- Non TCR Genetic Lesions in T-ALL -- Future Directions -- References -- Systems Approaches to Childhood Leukemogenesis -- Abstract -- Introduction -- The Necessity of "Marriage" of Biological Sciences and the other Exact Sciences -- Theories of Carcinogenesis -- Childhood Neoplasias and Childhood Leukemia -- Theories on Leukemogenesis -- Chemical, Radiation and InfectiousFactors Proposed as Affecting Leukemogenesis -- Cytogenetic Aberrations as Leukemogenetic Factors -- The Stem Cell Theories -- Evolutionary Theories of Leukemogenesis -- Some Physical Approaches to Leukemogenesis -- Conclusion -- References -- Histone Deacetylase Inhibitors: Pre-clinical and Clinical Evidence in Treating Acute Lymphoblastic Leukemia -- 1. Overview -- 2. Treatment Options for Leukemia -- 3. Histone Deacetylases (HDACs) and Histone Deacetylase Inhibitors (HDIs) -- 4. Evidence for HDIs as a Therapeutic Strategy in Acute Lymphocytic Leukemia -- 5. Preclinical and Clinical Trials of HDIs in Patients with Acute Lymphocytic Leukemia -- Conclusion -- Acknowledgment -- References -- A Therapeutic Target in Leukemia: The NK-1 Receptor -- Abstract -- Introduction -- Leukemia and the Substance P/Neurokinin-1 Receptor System -- Leukemia and Neurokinin-1 Receptor Antagonists -- Future Research and Conclusions -- Acknowledgment -- References -- Minimal Residual Disease Monitoring in Childhood Acute Lymphoblastic Leukemia -- Summary
Ιntroduction -- Techniques for MRD Monitoring -- ΜRD Monitoring by Multiparameter Flow Cytometric Immunophenotyping -- MRD Monitoring by PCR Analysis of Fusion Gene Transcripts -- MRD Monitoring by PCR Analysis of Immunoglobulin and T-cell Receptor Gene Rearrangements -- Prognostic Value of Minimal Residual Disease -- Conclusion -- References -- Clinical Relevance and Application of Cytogenetic Approaches in Pediatric Acute Lymphoblastic Leukaemia -- Summary -- Introduction -- Molecular Approaches -- Conventional Cytogenetics -- RT-PCR & RQ-PCR -- Southern Blotting -- FISH -- Multicolor Whole Chromosome Painting (M-FISH, SKY and COBRA-FISH) -- CGH and aCGH -- LOH -- Numerical Chromosomal Abnormalities -- High Hyperdiploidy -- Hypodiploidy -- Near Haploidy -- Pseudodiploidy and Diploidy -- Structural Chromosomal Abnormalities -- BCR/ABL -- Mixed Lineage Leukemia (MLL) Gene Rearrangements -- ETV6/RUNX1 -- TCF3/PBX1 or E2A/PBX1 -- Additional Recurrent Cytogenetic Abnormalities -- HOX11L2 -- NUP98-RAP1GDS1 -- 6q Deletions -- 9p Abnormalities -- Conclusion -- References -- Maintenance Therapy in Ph Negative Adult Acute Lymphoblastic Leukemia -- Standard Maintenance -- Current Practice -- Drugs for Maintenance Therapy -- Role of Intensification of Maintenance -- Maintenance Therapy after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT) -- MRD-evaluation for Decision Making -- Recommendation for Maintenance in Ph- ALL -- References -- The Role of Innate and Adaptive Immunity in Childhood Acute Lymphoblastic Leukemia -- Introduction -- The Innate Immune System in ALL -- The Adaptive Immune Response in ALL -- The Dysfunction of Immune Response in ALL -- Conclusion -- References -- Index
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Vecchione, Severo Acute Lymphoblastic Leukemia: Etiology, Pathogenesis and Treatments Hauppauge : Nova Science Publishers, Incorporated,c2012 9781614708728
Subject Lymphoblastic leukemia
Electronic books
Alt Author Tedesco, Luigi
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