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Author Webster, Yue Wang
Title A hybrid approach for translational research
book jacket
Descript 69 p
Note Source: Dissertation Abstracts International, Volume: 71-07, Section: B, page:
Advisers: Mathew Palakal; Josette Jones
Thesis (Ph.D.)--Indiana University, 2010
Translational research has proven to be a powerful process that bridges the gap between basic science and medical practice. The complexity of translational research is two-fold: integration of vast amount of information in disparate silos, and dissemination of discoveries to stakeholders with different interests. We designed and implemented a hybrid knowledge discovery framework. We developed strategies to leverage both traditional biomedical databases and Health Social Network Communities content in the discovery process. Heuristic and quantitative evaluations were carried out in Colorectal Cancer and Amyotrophic Lateral Sclerosis disease areas. The results demonstrate the potential of our approach to bridge silos and to identify hidden links among clinical observations, drugs, genes and diseases, which may eventually lead to the discovery of novel disease targets, biomarkers and therapies
School code: 0093
Host Item Dissertation Abstracts International 71-07B
Subject Information Science
Health Sciences, Health Care Management
Alt Author Indiana University. Informatics
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