Record:   Prev Next
Author Woelders, Henri
Title Systems Biology and Livestock Science
Imprint Hoboken : John Wiley & Sons, Incorporated, 2011
©2011
book jacket
Edition 1st ed
Descript 1 online resource (756 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Cover -- Title Page -- Copyright -- List of Contributors -- Preface -- From livestock production to biological science: from systems biology to livestock production -- Chapter 1: Introduction to Systems Biology for Animal Scientists -- Why Should Animal Scientists Be Interested in Learning About Systems Biology? -- What Is Systems Biology? -- A Systems Biology Paradigm: The Progress in Analysis of the Mammalian Immune Response Network -- What Parts of Systems Biology Are in Use in Animal Science Today? -- Further Reading -- Partial Listing of Online Resources for Systems Biology -- Web sites -- Acknowledgments -- Chapter 2: Modeling Approaches in Systems Biology, Including Silicon Cell Models -- What Is Systems Biology -- Various Systems Biological Models -- Three Strategies to Build a Model: Top-Down, Middle-Out, and Bottom-Up -- Perspectives of Silicon Cell Models: Advantages and Concerns -- Use of Systems Biological Models, Including Silicon Cell Models -- Acknowledgments -- Chapter 3: The IUPS Physiome Project: A Worldwide Systems Biology Initiative -- Introduction -- Fundamental Principles of the Physiome Project -- The Framework and Strategies of the Physiome Project -- The Current Status of Physiome Modeling -- Conclusions and Future Directions -- Acknowledgments -- Chapter 4: Systems Biology in Livestock Health and Disease -- Introduction -- Defining Systems Biology in the Medical Context -- Establishing the Need for Systems Biology Approaches in Human and Veterinary Medicine -- Systems Biology and Personalized Healthcare in Human Medicine -- Areas of Application of Systems Biology to Human Medicine -- Barriers to Implementing Personalized Medicine in Human Medical Practice -- Systems Biology Techniques -- Novel Technologies -- Personalized Medicine Versus Livestock Population Health -- Molecular Diagnostics
Using Systems Biology to Understand Host-Pathogen Interactions -- Molecular Epidemiology -- Example of Systems Biology Applications in Livestock Health: Mastitis in Dairy Cattle -- Conclusion: Challenges of Applying Systems Biology Concepts and Techniques to Livestock Health Management -- Chapter 5: Systems Biology of Host-Food-Microbe Interactions in the Mammalian Gut -- The Gastrointestinal Tract and Body Homeostasis -- The Need for Systems Approaches to Study Diet-Host-Microbiota Interactions -- The Gastrointestinal (GI) Tract -- Energy Homeostasis -- Signaling and Hormone Homeostasis -- Homeostasis of Tolerance and Immunity -- Nutritional Challenges -- The Intestinal Microbiota -- Integrated Modeling Approaches -- Challenges Ahead -- Conclusions -- Chapter 6: From Visual Biological Models Toward Mathematical Models of the Biology of Complex Traits -- Introduction -- Generation of a Biological Model -- Association Studies Relating the Expression Levels of Genes or Proteins to Quantitative Traits -- Bioinformatics Toward Systems Biology: Biological Models Toward Mathematical Models -- Future Expectations -- Acknowledgments -- Chapter 7: Molecular Networks as Sensors and Drivers of Uterine Receptivity in Livestock -- Introduction -- Transcriptome Analysis as a Holistic Approach for the Study of Cellular Changes at the Molecular Level -- Resources for Functional Gene Annotation and Gene/Protein Interactions and Corresponding Analysis Tools -- Identification of Biological Themes Related to Endometrial Remodeling and Receptivity in a Microarray Study of Bovine Endometrium During the Estrous Cycle -- Correlation of Gene Expression Data and Data from Genome-Wide Association Studies (GWAS) Links Differential Gene Expression with Phenotypes Related to Fertility
Identification of Genes Involved in Preparation of the Bovine Endometrium for Embryo Implantation -- Analysis of Gene Expression in Endometrium During the Preimplantation Phase in Porcine Endometrium -- Analysis of Gene Expression in Endometrium During the Preimplantation Phase in Equine Endometrium -- Comparison of Gene Expression Datasets from Different Mammalian Species -- Identification of Fertility-Related Genes by the Analysis of Pathological Conditions -- Strategies and Approaches to Obtain Deeper Insights into and Better Understanding of the Processes Related to Establishment and Maintenance of Pregnancy -- Chapter 8: Modeling Approaches to Link Various Levels of Organization in Animal Physiology -- Introduction -- Levels of Organization -- Modeling Approaches -- Some Examples of Physiological Aspects -- Implications and Perspectives -- Acknowledgments -- Chapter 9: Systems Biology and Animal Nutrition: Insights from the Dairy Cow During Growth and the Lactation Cycle -- Introduction -- The Peripartal Dairy Cow as a Model for Whole-Animal Systems Biology -- The Mammary Gland as a Unique System -- Intertissue Cross Talk During Prepubertal Bovine Mammary Development -- Effect of Prepartal Nutrient and Energy Intake on Dairy Cow Adipose Tissue -- Effect of Prepartal Nutrient and Energy Intake on Dairy Cow Liver -- Dietary Lipid Supplementation, Ruminal Metabolism, and the Mammary Gland Transcriptome -- Perspectives -- Acknowledgments -- Chapter 10: Host-Pathogen Interactions -- Introduction -- Data Explosion and the Rationale for Systems Biology Approaches -- Infection Biology -- Complexity and Scales -- Mathematical Models -- Interaction Models -- Conclusions -- Chapter 11: Systems Biology in Livestock Science and Commercial Livestock Business -- Introduction -- Expectations from Systems Biology for Livestock Science and Industrial Innovations
Conclusions -- Color plates -- Index
Marinus F.W. te Pas is a Senior Research Scientist of Genomics and Bioinformatics at the Animal Breeding and Genomics Centre, Wageningen UR Livestock Research. Henri Woelders is a Senior Research Scientist of Reproduction and Fertility, Animal Breeding and Genomics Centre, Wageningen UR Livestock Research. André Bannink is a Research Scientist in Animal Nutrition, Wageningen UR Livestock Research
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Woelders, Henri Systems Biology and Livestock Science Hoboken : John Wiley & Sons, Incorporated,c2011 9780813811741
Subject Veterinary physiology -- Computer simulation.;Livestock.;Livestock -- Genetics -- Computer simulation
Electronic books
Alt Author Bannink, André
te Pas, Marinus
Bannink, André
Bannink, André
Record:   Prev Next