LEADER 00000cam  2200709 i 4500 
001    ocm958371110 
003    OCoLC 
005    20180318231228.0 
008    160908t20172017nyu      b    001 0 eng   
010    2016024105 
020    9780190651244|q(hardback) 
020    0190651245|q(hardback) 
035    (OCoLC)958371110 
040    DLC|beng|erda|cDLC|dAS|dEAS 
042    pcc 
050 00 QR181|b.T37 2017 
082 00 616.07/9|223 
100 1  Tauber, Alfred I 
245 10 Immunity :|bthe evolution of an idea /|cAlfred I. Tauber 
264  1 New York, NY, United States of America :|bOxford 
       University Press,|c[2017] 
264  4 |c2017 
300    xx, 303 pages ;|c25 cm 
336    text|btxt|2rdacontent 
337    unmediated|bn|2rdamedia 
338    volume|bnc|2rdacarrier 
504    Includes bibliographical references and index 
505 0  A History of the Immune Self -- Whither Immune Identity? -
       - Individuality Revised -- Immune Cognition -- Eco-
       immunology -- A New Biology? 
520    "Senior scholar Alfred Tauber argues in this bold account 
       that common approaches to the study of immunology are 
       inherently flawed in its strict dichotomy of the self and 
       non-self, or external invaders. The relationship between 
       what is self and what is non-self is in reality a complex,
       dymanic, relational one. Autonomous agents are constantly 
       in the midst of dialectical exchanges in which immunity 
       mediates both noxious and benign encounters. Namely: 
       rather than serving to defend an independent entity, 
       immunity participates in an eco-system. Contemporary 
       transplantation biology and autoimmunity have demonstrated
       phenomena that upset rigid adherence to the self/non-self 
       dichotomy. Placing tolerant immune mechanisms within a 
       broad ecological context has highlighted the balance of co
       -operative and competitive relationships in which immunity
       functions. By understanding immunity this way, as a 
       'symbiotic turn, ' we come to see that immune reactivity 
       (rejection or tolerance) is a second-order response to the
       cognitive functions of the immune system. Organisms have a
       complex capacity to respond to environment, and, through 
       Tauber's insignts, we appreciate them more fully when we 
       grasp the flexibility of the borders of organisms. After 
       first providing an overview of the history of immunology, 
       and explaining why the dominant understanding of it is 
       incomplete and limiting, Tauber argues for this new 
       approach to immunology and explains how it will usher in a
       new biology in which symbiosis is the rule, not the 
       exception."--|cProvided by publisher 
520    "Immunity mediates both defensive and cooperative 
       relations with the environment. Therefore, the traditional
       focus on host defense misconstrues the full spectrum of 
       immune activities. An alternate model based on immune 
       balance highlights the information processing of immune 
       perception that precedes discriminatory decisions -- to 
       reject, assimilate, or ignore the identified object"--
       |cProvided by publisher 
650  0 Immunology|xPhilosophy 
650 12 Allergy and Immunology 
650 22 Philosophy, Medical 
 Euro-Am 3F Western Mat.  616.079 T191 2017    AVAILABLE  -  30500101487950