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Author Melino, Gerry
Title Cell Death
Imprint Hoboken : John Wiley & Sons, Incorporated, 2010
©2009
book jacket
Edition 1st ed
Descript 1 online resource (317 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Cover -- Cell Death -- Copyright Page -- Contents -- Contributors -- Preface -- The Siren's Song: This Death That Makes Life Live -- References -- Further Reading -- The Origin and Evolution of Programmed Cell Death -- Introduction -- Origins: From the Question 'When' to the Question 'How' -- From Predator/Prey Coevolution to Symbioses: A 'Red Queen' Hypothesis in the Bacteria World -- A Stable Evolutionary Strategy despite High Individual Costs -- The 'Original Sin' Hypothesis: Self-destruction as an Unavoidable Consequence of Life -- C. elegans Model: From Paradigm to Paradox -- Walking Around the Evolutionary Bush -- From the Origins of Programmed Cell Death to the Origins of Ageing -- 'There is Grandeur in This View of Life...' -- References -- Further Reading -- Cell Death in C. elegans -- ced-3, ced-4, ced-9 and egl-1 are Conserved Genes Essential for Programmed Cell Death in C. elegans -- Regulation of Cell Death during Somatic Development -- Engulfment of Dying Cells -- Germline Apoptosis -- DNA Damage-induced Germline Apoptosis -- Conclusion -- References -- Further Reading -- Caspases and Cell Death -- History and Classification -- Structure and Active Site -- Substrate Recognition and Mechanism of Action -- Sequence of Action -- Substrates during Apoptosis -- Inhibitors -- Caspase Knockouts -- Pathological Implications -- Therapeutic Outlook -- References -- Further Reading -- The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis -- Introduction -- The Apoptosome Structure: Its Components and Its Assembly -- Apaf1 -- Apoptosome assembly -- Caspase-9 -- Cytochrome c -- Modulation of the Apoptosome Formation -- Apoptosome-like Complexes in Evolution. Is the Mitochondrial Pathway of Apoptosis Conserved? -- Caenorhabditis elegans -- Drosophila melanogaster -- The Role of the Apoptosome in Mammalian Development
Caspase-9 knockout -- Apaf1 knockout -- Cytochrome c deficiency -- Final Remarks -- References -- Further Reading -- Caspases, Substrates and Sequential Activation -- Introduction -- Caspases Classification and Structure -- Pathways That Lead to Caspase Activation -- Extrinsic pathway -- Granzyme B pathway -- Intrinsic pathway -- Effectors of demolition -- Demolition Phase of Apoptosis -- Detachment, rounding and blebbing -- Nuclear fragmentation, DNA condensation and degradation -- Undermining cell physiology -- Immune Clearance and Immune Tolerance of Apoptotic Cells -- Conclusions -- Acknowledgements -- References -- Further Reading -- Dismantling the Apoptotic Cell -- Introduction -- Caspases: Regulators of the Apoptotic Process -- Activation of the apoptotic caspases -- Effect of caspase-mediated cleavage on target substrates - gain- or loss-of-function -- Cleavage of caspase substrates leads to key morphological changes during apoptosis -- Cytoskeletal events and membrane blebbing -- Nuclear events -- Changes in the Golgi apparatus -- Caspases alter the transcriptional and translational machinery -- Survival pathways are targeted during apoptosis -- The apoptotic cell calls for its own disposal -- Caspase-independent cell death -- Concluding Remarks -- References -- Further Reading -- The BCL-2 Family Proteins - Key Regulators and Effectors of Apoptosis -- Introduction -- Structure -- Binding between Family Members -- Evolution of BCL-2 Family Proteins -- Integration and Regulation of Apoptotic Signals -- Roles In Vivo -- Apoptosis and Cancer -- BCL-2 Antagonist Drugs -- References -- Further Reading -- BH3-only Proteins -- Introduction -- Overview of the apoptotic machinery -- The 'Bcl-2-regulated' ('mitochondrial', 'intrinsic') apoptotic pathway -- The role of the Bcl-2 family in tumourigenesis -- Noxa and Puma -- Bid -- Bim/Bod/Bcl2L11
Bik/Nbk/Blk -- Bad -- Bmf -- Hrk/DP5 -- BH3-Mimetic Drugs -- Conclusions -- References -- Further Reading -- Mitochondrial Outer Membrane Permeabilization -- Introduction -- Caspases are the central machinery of apoptosis -- Apoptosis can be broadly defined by two main pathways -- Intrinsic Apoptotic Signalling -- The Bcl-2 Family Controls MOMP -- There are Two Models to Explain the Induction of MOMP -- The Role of Mitochondrial Fission and Fusion in MOMP -- The Role of Mitochondrial Bioenergetics in MOMP -- MOMP Controlled from the Inside -- Summary -- References -- Further Reading -- Mitochondria Fusion and Fission -- Introduction -- Ultrastructure of mitochondria -- Dynamic network-like organization of mitochondria in the cell -- Regulation of Mitochondrial Fusion and Fission -- Mitochondrial Fusion -- Mitochondrial fission -- Cellular role of Mitochondrial Network Organization: An Overview -- Role of Mitochondrial Dynamics in Cell Death -- Role of Bcl-2 Family in the Regulation of Mitochondrial Network Dynamics -- Role of core mitochondrial fusion and fission proteins in progression of apoptosis -- Acknowledgements -- References -- Further Reading -- Death Receptors -- Introduction -- Structure -- Death Ligands and Initiation of Death Receptor Signalling -- Caspases in Death Receptor Signalling -- CD95/Fas/APO-1 Signalling -- TRAIL- R1/TRAIL-R2 Signalling -- TNF Signalling -- DR3 and DR6 signalling -- Modulation of DR-induced Apoptosis -- References -- Further Reading -- Death Receptors at the Molecular Level: Therapeutic Implications -- Introduction -- Death Receptors as Potential Therapeutic Targets -- TRAIL/TRAIL-Receptors - Lessons from Studies at the Molecular Level -- Targeting TRAIL Death Receptors for Cancer Therapy -- References -- Further Reading -- Death Receptor-induced Necroptosis -- Introduction
Death Receptor-induced Necroptosis Signalling Complexes -- Death Receptor-induced Necroptosis, Dying from too much Respiration -- The Way to Necroptosis is Paved with Many Pathways -- Physiological Role of Necroptosis -- Conclusions and Perspectives -- Acknowledgements -- References -- Further Reading -- Inhibitor of Apoptosis (IAP) and BIR-containing Proteins -- Introduction -- Structure of the BIR fold -- RING Domains -- UBA domains -- XIAP -- ML-IAP -- cIAP1 and cIAP2 -- IAPs and Cancer -- IAP-antagonist Compounds -- Survivin and BRUCE -- NAIP -- References -- Further Reading -- Structures, Domains and Functions in Cell Death (DD, DED, CARD, PYD) -- Introduction -- Functions of DDs, DEDs, CARDs and PYDs: Assembly of Caspase-activating Signalling Complexes -- Death-inducing signalling complex for activation of caspase-8 and caspase-10 and its inhibition by FLIPs -- Apoptosome for caspase-9 activation -- PIDDosome for caspase-2 activation -- Inflammasome for caspase-1 activation -- Structures of Isolated Domains and Their Surface Features -- Interactions in the DD Superfamily -- DD:DD interaction in the Pelle:Tube complex -- CARD:CARD interaction in the Apaf1:procaspase-9 complex -- DED:DED interaction in the tandem DED structure of MC159 v-FLIP -- Asymmetric oligomeric DD:DD interaction in the PIDD:RAIDD complex -- Oligomeric DD:DD interaction in the Fas:FADD complex -- Preferred Modes among the Homotypic Interactions -- Summary -- Acknowledgement -- References -- Further Reading -- Structure and Function of IAP and Bcl-2 Proteins -- Introduction -- Structural Basis of Bcl-2 Family Action -- Membrane Interactions and the Bcl-2 Family -- Structural Basis of IAP Function -- Caspase Regulation by IAPs -- The RING E3-ligase Activity of IAPs -- IAP and Bcl-2 Antagonists: A Route to New Cancer Therapies? -- Summary -- References -- Further Reading
Engulfment of Apoptotic Cells and its Physiological Roles -- Introduction -- ''Find-me'' Signals -- ''Eat-me'' Signals -- Signaling Pathways for Engulfment -- Engulfment Mediated by Bridging Molecules -- Phosphatidylserine Receptors -- Immunosuppressive Roles of Engulfment -- Conclusions and Future Prospects -- References -- Further Reading -- Autophagy -- General Overview: Introduction to Autophagy -- Molecular Dissection of Autophagy -- Two ubiquitin-like conjugations systems -- Two kinases -- Rabs, SNAREs and more -- Regulation of the Autophagic Pathway -- Autophagy in Pathological Processes -- Neurodegenerative diseases -- Myodegenerative diseases -- Cardiac diseases -- Cancer -- Infectious and inflammatory diseases -- Autophagy and Cell Death -- Concluding Remarks -- References -- Further Reading -- Autophagy in Nonmammalian Systems -- Introduction -- Regulation of Autophagy -- Functions of Autophagy -- Survival during nutrient restriction and oxidative stress -- Development -- Cell Death -- Disease Models -- Infectious disease -- Neurodegeneration -- Ageing -- Conclusion -- Acknowledgement -- References -- Further Reading -- Apoptosis: Regulatory Genes and Disease -- Introduction -- Intrinsic or Bcl-2 blockable apoptosis -- Extrinsic death receptor apoptosis pathways -- Death receptor activation of pro-survival signalling -- Perforin and granzyme B-induced cell death -- Dysregulation of the Intrinsic and Extrinsic Apoptotic Pathways in Disease -- Dysregulation and Disease in the Intrinsic Bcl-2 Blockable Apoptotic Pathway -- p53 -- Bcl-2 -- Bcl-xL -- XIAP -- Perforin and Granzyme B -- Dysregulation and Disease in the Extrinsic Apoptosis Pathway -- Targeting death receptors in cancer -- Fas and disease -- TNF receptor signalling and disease -- cIAP1 and cIAP2 and disease -- References -- Further Reading -- Caspases in Inflammation and Immunity
Preface
This book on cell death contains 29 self-contained, peer-reviewed articles written by leading scientists in each field. It features overview articles aimed at undergraduates and non-specialists, which present basic information and provide entry into the following advanced articles. These advanced articles are written for postgraduate students and research workers, containing detailed information and key references allowing the reader to investigate a specific area in more depth. The book is an essential resource for educational purposes as well as a reference work for experienced researchers in the field. The articles will also be available electronically as part of the acclaimed Encyclopedia of Life Sciences (ELS). Key features: Provides a comprehensive overview on the research of programmed cell death. Edited by leaders in the field. Clearly written and illustrated articles. Full colour throughout. A spin-on to the acclaimed reference work, the Encyclopedia of Life Science (ELS). Combines introductory information with coverage of the latest discoveries in the field. Features overview level articles for advanced students or people new to a topic and more advanced articles for those requiring more detailed information. Serves as a reference work for advanced students as well as researchers in this field. Ideal library purchase for science, medical, and technology libraries in academia, government, and industry; medical libraries; networks and consortia covering these markets
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Melino, Gerry Cell Death Hoboken : John Wiley & Sons, Incorporated,c2010 9780470715734
Subject Apoptosis.;Cell death
Electronic books
Alt Author Vaux, David
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