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Author Hochhauser, Daniel
Title Cancer and Its Management
Imprint Somerset : John Wiley & Sons, Incorporated, 2014
©2014
book jacket
Edition 7th ed
Descript 1 online resource (627 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Cover -- Title Page -- Copyright -- Contents -- Preface -- Acknowedgements -- Abbreviations -- Chapter 1 The modern management of cancer: an introductory note -- References -- Further reading -- Chapter 2 Epidemiology, cure, treatment trials and screening -- Terminology and methods in epidemiology -- Geographical distribution of cancer -- Temporal distribution of cancer -- Causes of cancer suggested by epidemiological studies -- Inhaled carcinogens -- Lifestyle and diet -- Ionizing irradiation -- Occupational factors -- Viral causes -- Cancer statistics -- Survival data and determination of cure in cancer -- Assessment of results: trials of treatment -- Randomized trials -- Informed consent -- Non-randomized studies of treatment -- Screening for cancer -- Secondary prevention of cancer -- References -- Further reading -- Chapter 3 Biology of cancer -- Carcinogenesis: persistent genetic damage -- Chemical carcinogens -- Ionizing and ultraviolet irradiation -- Initiators and promoters in carcinogenesis -- Repair of damage to DNA induced by carcinogens -- Inherited defects involving DNA damage or repair processes that predispose to cancer -- Viral causes of cancer -- RNA viruses -- DNA viruses -- Cellular oncogenes -- Tumour-suppressor genetic mechanisms in cancer development -- Cell division -- Inheritance of cancer -- Clonal origin, progression and growth of a cancer -- Monoclonality and heterogeneity in cancer -- The growth of cancer -- Differentiation in cancer -- Invasion, angiogenesis and metastasis -- Tumour immunology -- Immune responses to cancer -- Monoclonal antibodies -- Reference -- Further reading -- Chapter 4 Staging of tumours -- Staging notation -- The primary tumour (T) -- Lymph node involvement (N) -- Presence of metastases (M) -- Staging techniques -- Ultrasound -- Computed tomography -- Magnetic resonance imaging
Isotope scanning -- Positron emission tomography -- Diagnosis of specific metastatic sites -- Pulmonary metastases -- Bone metastases -- Hepatic metastases -- Brain metastases -- The role of surgery in diagnosis and staging -- Tumour markers -- Human chorionic gonadotrophin -- α-Fetoprotein -- Placental alkaline phosphatase -- Carcinoembryonic antigen -- CA-125 -- CA-19-9 -- Molecular staging of cancer -- References -- Further reading -- Chapter 5 Radiotherapy -- Sources and production of ionizing radiation -- Radioactive isotopes -- Artificial production of X-rays and particles -- Biological properties of ionizing radiation -- Tumour sensitivity -- Fractionation and cell death -- Response of biological tissues to radiation -- Normal tissues -- Highly radiosensitive tissues -- Moderately radiosensitive tissues -- Less radiosensitive tissues -- Late sequelae of radiation -- Carcinogenesis -- Teratogenicity -- Mutagenicity -- Technical aspects of radiotherapy -- Radiotherapy planning and treatment techniques -- Treatment prescription -- Maximum, minimum and modal dose -- Open (direct) and wedged fields -- Parallel opposed fields -- Shrinking field technique -- Systemic irradiation -- Immobilization devices -- Conformal and intensity-modulated radiation therapy -- Integration of radiotherapy and chemotherapy -- Proton therapy -- References -- Further reading -- Chapter 6 Systemic treatment for cancer -- Chemotherapy -- The cellular targets for anticancer drugs -- The development of an anticancer drug -- Principles of cancer chemotherapy -- The cell cycle -- Resistance to cancer chemotherapy -- Predicting sensitivity to anticancer drugs -- What cancer chemotherapy has achieved -- Classes of cytotoxic drugs, mode of action and toxicity -- Targeted therapy for cancer -- Hypersensitivity reactions -- The administration of cytotoxic agents
Chemotherapy-induced vomiting -- Long-term complications of cancer chemotherapy -- Principles of hormone therapy -- Steroid hormone receptors -- Hormone receptor assays -- Approaches to hormone therapy -- Cytokines in cancer treatment -- Interferons -- Interleukins -- Monoclonal antibodies in cancer therapy -- Gene therapy -- Immunotherapy -- References -- Chapter 7 Supportive care and symptom relief -- Talking about the diagnosis and treatment -- Support, counselling and rehabilitation -- Stoma care -- Breast prostheses -- Laryngectomy rehabilitation -- Limb prostheses -- Other prostheses -- Home support -- National counselling organizations -- Cancer treatment and the quality of life -- Symptom control [3,4] -- Pain -- Anorexia and nausea [10] -- Oral mucositis -- Constipation -- Intestinal obstruction -- Depression and anxiety -- The care of the dying -- Terminal care: home, hospice and support teams -- Cancer quackery -- References -- Further reading -- Chapter 8 Medical problems and radiotherapy emergencies -- Bone marrow failure and its consequences -- The management of marrow depression by blood component therapy -- Haemopoietic growth factors [3] -- Clinical use of haemopoietic growth factors -- Infections in the immunocompromised patient -- Bacteraemia and septicaemia -- Respiratory infection -- Urinary tract infections -- Gastrointestinal infections -- Meningitis -- Skin infections -- Prevention of infection in the leucopenic patient -- Cancer cachexia and the nutritional support of the cancer patient -- Pathogenesis of malnutrition in cancer -- Maintaining nutrition -- Acute metabolic disturbances -- Hypercalcaemia -- Tumour lysis syndrome -- Serous effusions -- Pleural effusion [17] -- Pericardial effusion -- Ascites -- Carcinomatous meningitis -- Progressive multifocal leucoencephalopathy -- Management of hepatic metastases
Pharmacological -- Radiotherapeutic (and radiofrequency) ablation -- Surgical -- Radiotherapeutic emergencies -- Acute spinal cord or cauda equina compression -- Superior vena caval obstruction -- Other radiotherapy emergencies -- Cancer during pregnancy -- References -- Further reading -- Chapter 9 Paraneoplastic syndromes -- Fever due to malignant disease -- Ectopic hormone production in cancer -- Syndrome of inappropriate antidiuretic hormone secretion -- Ectopic adrenocorticotrophic hormone production -- Hypoglycaemia -- Gynaecomastia and gonadotrophin production -- Other ectopic hormones -- Haematological syndromes -- Anaemia -- Erythrocytosis -- Thrombotic disorders -- Disseminated intravascular coagulation -- Neurological syndromes -- Encephalomyelitis -- Cerebellar degeneration -- Carcinomatous myelopathy -- Peripheral neuropathy -- Lambert-Eaton myasthenic syndrome -- Muscle and joint syndromes -- Polymyositis and dermatomyositis -- Hypertrophic pulmonary osteoarthropathy -- Polyarthritis -- Dermatological syndromes -- Acanthosis nigricans -- Hypertrichosis (lanuginosa acquisita) -- Erythroderma -- Vasculitis -- Pyoderma gangrenosum -- Bullous eruptions -- Ichthyosis -- Alopecia -- Generalized pruritus -- Nephrotic syndrome -- References -- Chapter 10 Cancer of the head and neck -- Introduction, aetiology and epidemiology -- Pathology -- Clinical staging -- Distant metastasis -- Investigation -- Carcinoma of the larynx -- Management and prognosis -- Conservative surgery in laryngeal cancer -- Rehabilitation -- Carcinoma of the pharynx -- Anatomy and patterns of metastasis -- Carcinoma of the nasopharynx -- Carcinoma of the oropharynx -- Lymphoma of the pharynx -- Carcinoma of the laryngopharynx (hypopharynx) -- Tumours of the oral cavity -- Management -- Carcinoma of the lip -- Treatment -- Nasal cavity and paranasal sinuses
Tumours of the middle ear -- Carcinoma of the pinna and external auditory canal -- Chemotherapy in squamous carcinomas of the head and neck -- Tumours of salivary glands -- Clinical features and management -- Prognosis -- Tumours of the orbit and eye [59,60] -- Orbit -- Tumours of the eyelid and conjunctiva -- Tumours of the globe -- References -- Further reading -- Chapter 11 Brain and spinal cord -- Brain tumours -- Cellular biology of brain tumours -- Pathological classification of brain tumours -- Clinical features -- Management of brain tumours -- Treatment on relapse -- Prognosis of brain tumours -- Secondary deposits in the brain -- Tumours of the spinal cord [65,66] -- Symptoms -- Differential diagnosis -- Investigation -- Management -- Tumours of the peripheral nerves -- Radiation damage in the brain and spinal cord -- References -- Further reading -- Chapter 12 Tumours of the lung and mediastinum -- Carcinoma of the bronchus -- Introduction, aetiology and epidemiology -- The molecular pathology of lung cancer -- Pathology of lung cancer -- Patterns of local invasion and metastasis -- Clinical features -- Staging notation -- Investigation and staging -- Treatment -- Prognosis of lung cancer: geographical variation of lung cancer mortality rates -- Tumours of the mediastinum -- Anterosuperior mediastinum -- Middle mediastinum -- Posterior mediastinum -- Mesothelioma -- Pathology -- Clinical features -- Diagnosis -- Treatment -- Primary tracheal tumours -- References -- Further reading -- Chapter 13 Breast cancer -- Incidence, aetiology and epidemiology -- Pathology and mode of spread -- Clinical features -- Confirming the diagnosis -- Preoperative investigation -- Staging notation -- Hormone receptors in breast cancer -- Screening for breast cancer -- Management of the primary tumour in 'early' breast cancer
Combinations of surgery and radiotherapy [39-41]
Now in its seventh edition, this highly-regarded book is designed as an introductory and reference text on the principles of diagnosis, staging, and treatment of tumors. As for the last 6 editions of the book, the aim and scope of the new edition are once again to provide a thorough yet reasonably brief account of the whole field of oncology, focusing on the latest principles of cancer management.  The book is already well established, having been first published in 1986 and in continuous print since then. The authors are rightfully proud of their strong legacy of providing carefully revised new editions of this standard and well-received cancer text for audiences in the UK and abroad.  Oncology is a very rapidly changing speciality, with many new treatments and even treatment modalities coming on stream with bewildering speed.  Besides a thorough general updating of the text, figures, and tables, the new seventh edition adds a new chapter on Molecular Targeted Therapy, making the book 30 chapters in total.  This accessible and practical resource is invaluable to trainees and specialists alike in oncology, palliative care and general medicine, as well as specialist nurses, general practitioners, medical students, and professions allied to medicine
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Hochhauser, Daniel Cancer and Its Management Somerset : John Wiley & Sons, Incorporated,c2014 9781118468739
Subject Cancer -- Treatment.;Cancer -- Diagnosis
Electronic books
Alt Author Tobias, Jeffrey S
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