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050  4 RA648.3 -- .C48 1991eb 
082 0  614.5/99 
100 1  Staff, National Research Council 
245 10 Children of Atomic Bomb Survivors :|bA Genetic Study 
264  1 Washington :|bNational Academies Press,|c1990 
264  4 |c©1991 
300    1 online resource (524 pages) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
505 0  THE CHILDREN OF ATOMIC BOMB SURVIVORS -- Copyright -- 
       Preface -- Contents -- Orientation -- BEGINNINGS -- THE 
       THREE PHASES OF THE STUDY -- Phase I (1948-1954) -- Phase 
       II (1955-1968) -- Phase III (1969-1990) -- AN ESTIMATE OF 
       THE GENETIC DOUBLING DOSE OF RADIATION -- REFERENCES -- 
       Genetic Effects of the Atomic Bombs in Hiroshima and 
       Nagasaki -- THE EFFECT OF EXPOSURE TO THE ATOMIC BOMBS ON 
       PREGNANCY TERMINATION IN HIROSHIMA AND NAGASAKI -- TABLE 
       OF CONTENTS -- LIST OF TABLES -- LIST OF FIGURES -- 
       CHAPTER I BACKGROUND -- CHAPTER II THE PLAN -- CHAPTER III
       A COMPARISON OF HIROSHIMA AND NAGASAKI -- CHAPTER IV THE 
       CRITERIA OF RADIATION EMPLOYED IN THE STUDY -- CHAPTER V 
       THE COMPARABILITY OF IRRADIATION SUBCLASSES -- CHAPTER VI 
       STATISTICAL METHODS -- CHAPTER VII ANALYSIS OF THE SEX 
       RATIO DATA -- CHAPTER VIII ANALYSIS OF THE MALFORMATION 
       DATA -- CHAPTER IX ANALYSIS OF THE STILLBIRTH DATA -- 
       CHAPTER X THE ANALYSIS OF THE BIRTHWEIGHT DATA -- CHAPTER 
       XI ANALYSIS OF THE DATA CONCERNING DEATH DURING THE NINE-
       MONTH PERIOD FOLLOWING DELIVERY -- CHAPTER XII THE 
       ANALYSIS OF THE ANTHROPOMETRIC DATA -- CHAPTER XIII THE 
       AUTOPSY FINDINGS -- CHAPTER XIV RECAPITULATION -- CHAPTER 
       XV PERMISSIBLE INFERENCES -- APPENDIX -- PROCEDURE FOR 
       CODING GENETICS SHORT-FORM QUESTIONNAIRES -- CODING 
       INSTRUCTIONS FOR GENETICS FOLLOW-UP QUESTIONNAIRES -- 
       CODING INSTRUCTIONS FOR PEDIATRICS FOLLOW-UP QUESTIONNAIRE
       -- REFERENCES -- SUBJECT INDEX -- NAME INDEX -- ATOMIC 
       BOMB EXPOSURE AND THE PREGNANCIES OF BIOLOGICALLY RELATED 
       PARENTS  A PROSPECTIVE STUDY OFGENETIC EFFECTS OF 
       IONIZING… -- REFERENCES -- Some Further Observations on 
       the Sex Ratio Among Infants Born to Survivors of the 
       Atomic Bombings of Hiroshima and Nagasaki -- STUDIES OF 
       THE SEX RATIO IN HIROSHIMA AND NAGASAKI -- DISCUSSION -- 
       Other Studies of the Effect of Radiation on the Sex Ratio 
       in Man 
505 8  On an Interpretation of the Present Studies -- SUMMARY -- 
       REFERENCES -- A Cohort-Type Study of Survival in the 
       Children of Parents Exposed to Atomic Bombings -- Factors 
       Determining the Design of the Study -- DESCRIPTION OF 
       STUDY PROCEDURES -- SOURCES OF VARIATION IN MORTALITY 
       OTHER THAN RADIATION -- THE RELATIONSHIP OF MORTALITY TO 
       EXPOSURE -- DISCUSSION -- EPILOGUE -- SUMMARY -- 
       REFERENCES -- MORTALITY IN THE CHILDREN OF ATOMIC BOMB 
       SURVIVORS AND CONTROLS -- ABSTRACT -- THE STUDY POPULATION
       -- STATISTICAL CONSIDERATIONS -- THE DATA -- DISCUSSION --
       LITERATURE CITED -- 8 Cytogenetic Study of the Offspring 
       of Atomic Bomb Survivors, Hiroshima and Nagasaki -- 1 
       INTRODUCTION -- 2 MATERIALS AND METHODS -- 3 RESULTS -- 
       3.1 Characteristics of the Study Sample -- 3.2 Types and 
       Frequencies of Chromosome Abnormalities -- 3.2.1 Sex 
       Chromosome Abnormalities -- 3.2.2 Autosomal Structural 
       Rearrangements -- 3.2.3 Autosomal Trisomics -- 4 
       DISCUSSION -- REFERENCES -- Search for Mutations Altering 
       Protein Charge and/or Function in Children of Atomic Bomb 
       Survivors: Final Report -- SUMMARY -- INTRODUCTION -- THE 
       PROTOCOL -- The Indicators -- The Study Cohorts -- 
       Biochemical Procedures -- Special Studies of Putative 
       Mutations -- Dosimetry -- RESULTS -- DISCUSSION -- 
       ACKNOWLEDGMENTS -- REFERENCES -- Congenital Malformations,
       Stillbirths, and Early Mortality among the Children of 
       Atomic Bomb Survivors: A Reanalysis -- INTRODUCTION -- 
       MATERIALS AND METHODS -- The Study Sample -- Dosimetry -- 
       Statistical Methods -- RESULTS -- UNCERTAINTIES -- Errors 
       in the Estimation of the Gonadal Absorbed Doses -- 
       Completeness of the Ascertainment of Death and Defect -- 
       DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- Malignant 
       Tumors during the First 2 Decades of Life in the Offspring
       of Atomic Bomb Survivors -- SUMMARY -- INTRODUCTION -- 
       DESIGN OF STUDY 
505 8  Definition of Sample and Sources of Data -- Diagnostic 
       Standards -- De Novo Origin of the Potentially Inherited 
       Malignancies in the Study -- Dosimetry -- Statistical 
       Procedures -- RESULTS OF ANALYSIS -- DISCUSSION -- 
       ACKNOWLEDGMENTS -- REFERENCES -- Mortality among the 
       Offspring (F1) of Atomic Bomb Survivors, 1946-85 -- 
       SUMMARY -- INTRODUCTION -- DESIGN OF THE STUDY -- The 
       population -- Dosimetry -- Characteristics of the study 
       population -- Method of analysis -- RESULTS -- All causes 
       of death and survival rates -- Excess relative risk for 
       mortality -- DISCUSSION -- REFERENCES -- The Children of 
       Parents Exposed to Atomic Bombs: Estimates of the Genetic 
       Doubling Dose of Radiation for Humans -- SUMMARY -- 
       INTRODUCTION -- BACKGROUND -- THE ESTIMATION OF THE AMOUNT
       OF RADIATION REACHING THE GONADS -- THE DATA -- 1. 
       Untoward Pregnancy Outcomes -- 2. Deaths among Live-born 
       Infants (exclusive of those resulting from a malignant 
       tumor) -- 3. Malignancies in the F1 -- 4. Frequency of 
       Balanced Structural Rearrangements of Chromosomes -- 5. 
       Frequency of Sex-Chromosome Aneuploids -- 6. Frequency of 
       Mutation Altering Protein Charge or Function -- 7. Sex 
       Ratio among Children of Exposed Mothers -- 8. Growth and 
       Development of the F1 -- IMPLICATIONS OF THE DATA -- 
       Approach 1 -- Approach 2 -- Approach 3 -- CALCULATION OF 
       THE DOUBLING DOSE -- DISCUSSION -- The Extrapolation to 
       the Effects of Chronic Radiation -- The Discrepancy 
       between This Estimate of a Genetic Doubling Dose and That 
       Projected from Studies on Mice -- The Future of These 
       Studies -- ACKNOWLEDGMENTS -- APPENDIX THE MUTATIONAL 
       COMPONENT IN THE INDICATORS -- REFERENCES -- THE 
       COMPARATIVE RADIATION GENETICS OF HUMANS AND MICE -- 
       Contents -- INTRODUCTION -- A PRECIS OF THE HUMAN DATA ON 
       THE GENETIC EFFECTS OF ACUTE RADIATION -- THE GENERATION 
       OF AN ESTIMATE OF THE DOUBLING DOSE FROM THE HUMAN DATA 
505 8  SOME UNUSUAL FEATURES OF THE ESTIMATE OF THE HUMAN 
       DOUBLING DOSE -- PRECIS OF THE MOUSE DATA ON THE GENETIC 
       EFFECTS OF ACUTE RADIATION -- THE GENERATION OF A DOUBLING
       DOSE FROM THE MOUSE DATA -- SOME UNUSUAL FEATURES OF THE 
       ESTIMATE OF THE MOUSE DOUBLING DOSE (FROM THE STANDPOINT 
       OF EXTRAPOLATION TO HUMANS) -- CONCLUSIONS -- 
       ACKNOWLEDGMENTS -- Literature Cited -- The Future of These
       Studies -- CURRENT RESEARCH PROJECTIONS -- THE LIMITATIONS
       OF THE NEW TECHNOLOGIES -- PARALLEL ANIMAL STUDIES -- 
       STAYING THE COURSE -- REFERENCES -- Biographical Sketches 
       -- Name Index -- Subject Index 
588    Description based on publisher supplied metadata and other
       sources 
590    Electronic reproduction. Ann Arbor, Michigan : ProQuest 
       Ebook Central, 2020. Available via World Wide Web. Access 
       may be limited to ProQuest Ebook Central affiliated 
       libraries 
650  0 Children of atomic bomb victims -- Health and hygiene -- 
       Japan -- Hiroshima-shi.;Children of atomic bomb victims --
       Health and hygiene -- Japan -- Nagasaki-shi.;Radiation -- 
       Toxicology.;Genetic toxicology 
655  4 Electronic books 
700 1  Neel, James J 
700 1  Schull, William J 
776 08 |iPrint version:|aStaff, National Research Council
       |tChildren of Atomic Bomb Survivors : A Genetic Study
       |dWashington : National Academies Press,c1990
       |z9780309045377 
856 40 |uhttps://ebookcentral.proquest.com/lib/sinciatw/
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