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Title Gene therapy for neurological disorders [electronic resource] : methods and protocols / edited by Fredric P. Manfredsson
Imprint New York, NY : Humana Press : Springer, ©2016
book jacket
Descript 1 online resource (xiv, 493 pages) : illustrations (some color)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Methods in molecular biology ; 1382
Springer protocols
Methods in molecular biology ; 1382
Springer protocols (Series)
Note Includes bibliographical references and index
Introduction to viral vectors and other delivery methods for gene therapy of the nervous system / Fredric P. Manfredsson -- Delivering transgenic DNA exceeding the carrying capacity of AAV vectors / Matthew L. Hirsch, Sonya J. Wolf, and R.J. Samulski -- Expression of multiple functional RNAs or proteins from one viral vector / Tomas Björklund -- Regulated gene therapy / Ludivine Breger [and others] -- Design of shRNA and miRNA for delivery to the CNS / Gabriela Toro Cabrera and Christian Mueller -- Tissue-specific promoters in the CNS / Sebastian Kügler -- Small-scale recombinant adeno-associated virus purification / Corinna Burger and Kevin R. Nash -- Lentivirus production and purification / Matthew J. Benskey and Fredric P. Manfredsson -- Viral vector production : adenovirus / Julius W. Kim [and others] -- Controlling AAV tropism in the nervous system with natural and engineered capsids / Michael J. Castle [and others] -- Altering tropism of rAAV by directed evolution / Damien Marsic and Sergei Zolotukhin -- Altering entry site preference of lentiviral vectors into neuronal cells by pseudotyping with envelope glycoproteins / Kenta Kobayashi [and others] -- Directed evolution of adenoviruses / Jason G. Smith -- Intraparenchymal stereotaxic delivery of rAAV and special considerations in vector handling / Matthew J. Benskey and Fredric P. Manfredsson -- MRI-guided delivery of viral vectors / Ernesto A. Salegio, John Bringas, and Krystof S. Bankiewicz -- Systemic gene therapy for targeting the CNS / Sara E. Gombash and Kevin D. Foust -- Widespread neuronal transduction of the rodent CNS via neonatal viral injection / Ji-Yoen Kim, Stacy D. Grunke, and Joanna L. Jankowsky -- AAV-mediated gene transfer to dorsal root ganglion / Hongwei Yu, Gregory Fischer, and Quinn H. Hogan -- Gene therapy of the peripheral nervous system : the enteric nervous system / Matthew J. Benskey and Fredric P. Manfredsson -- Gene therapy of the peripheral nervous system : celiac ganglia / Bradley Hammond and David L. Kreulen -- Convection enhanced delivery of recombinant adeno-associated virus into the mouse brain / Kevin R. Nash and Marcia N. Gordon -- Nonviral gene therapy of the nervous system : electroporation / Xue-Feng Ding and Ming Fan -- Non-viral, lipid-mediated DNA and mRNA gene therapy of the central nervous system (CNS) : chemical-based transfection / James G. Hecker -- Ex vivo gene therapy using human mesenchymal stem cells to deliver growth factors in the skeletal muscle of a familial ALS rat model / Masatoshi Suzuki and Clive N. Svendsen -- Gene therapy models of Alzheimer's disease and other dementias / Benjamin Combs, Andrew Kneynsberg, and Nicholas M. Kanaan -- Viral vector-based modeling of neurodegenerative disorders : Parkinson's disease / D. Luke Fischer [and others] -- Gene therapy-based modeling of neurodegenerative disorders : Huntington's disease / Deborah Young -- Gene therapy for the treatment of neurological disorders : amyotrophic lateral Sslerosis / Zachary T. McEachin, Anthony Donsante, and Nicholas Boulis -- Stereotaxic surgical targeting of the nonhuman primate caudate and putamen : gene therapy for Huntington's disease / Jodi L. McBride and Randall L. Clark -- Gene therapy for the treatment of neurological disorders : metabolic disorders / Dominic J. Gessler and Guangping Gao -- Gene therapy for the treatment of neurological disorders : central nervous system neoplasms / Neha Kamran [and others] -- AAV2-neurturin for Parkinson's disease : what lessons have we learned? / Jeffrey H. Kordower
Online resource; title from PDF title page (SpringerLink, viewed November 30, 2015)
Subject Nervous system -- Diseases -- Gene therapy -- Laboratory manuals
Nervous System Diseases -- therapy
Genetic Therapy -- methods
Genetic Vectors
Electronic books
Alt Author Manfredsson, Fredric P., editor
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