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Author Lee, Samuel S
Title Cirrhosis : A Practical Guide to Management
Imprint New York : John Wiley & Sons, Incorporated, 2015
©2015
book jacket
Edition 1st ed
Descript 1 online resource (613 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Intro -- Title Page -- Copyright -- List of Contributors -- Foreword -- List of Abbreviations -- Part 1: Diagnosis and Pathophysiology -- Chapter 1: Clinical Clues to the Diagnosis of Cirrhosis -- Introduction -- Clinical Presentation -- Patient History -- Etiologic History Taking -- Examination -- References -- Chapter 2: Diagnostic Laboratory Tests -- Introduction -- Tests that Detects Hepatic Injury (Table 2.1) -- Specific Tests for Determining the Etiology of Liver Cirrhosis -- Conclusions -- References -- Chapter 3: Diagnostic Imaging Modalities -- Ultrasonography-Based Approaches -- CT- and MRI-Based Approaches -- References -- Chapter 4: Histology/Pathology -- Introduction -- Cirrhosis: A Pathologic Spectrum -- Cirrhosis: An Evolving Concept -- Cirrhosis: A Preneoplastic Condition -- Cirrhosis: A Place for Biopsy? -- References -- Chapter 5: Fibrosis and Fibrogenesis -- Introduction -- Mechanism of Liver Fibrosis in Hepatitis B and C -- Diagnosis of Liver Fibrosis by Imaging -- Diagnosis of Liver Fibrosis by Laboratory Tests -- Cell Types Involved in Liver Fibrosis -- Genes Involved in Liver Fibrosis -- Onset and Progression of Liver Fibrosis -- Regulation and Treatment of Liver Fibrosis -- References -- Chapter 6: Non-Invasive Diagnosis Tests -- Introduction -- Biologic Approach: Serum Biomarkers of Liver Fibrosis -- Physical Approach: Measurement of Liver Stiffness -- Alternatives to Transient Elastography -- Monitoring of Disease Progression and Prognosis -- Conclusions -- References -- Chapter 7: Evaluating Prognosis1 -- Introduction -- Natural History -- Child-Pugh Score -- MELD Score -- MELD Modifications -- Child-Pugh Score Versus MELD Score -- Hepatic Venous Pressure Gradient -- Variceal Bleed -- Surgery and Cirrhosis -- Intensive Care for Cirrhotic Patients -- Disease-Specific Models -- Conclusions -- References
Chapter 8: End-Stage Liver Failure: Liver Transplant Evaluation -- Introduction -- Epidemiology -- Surgical Aspects of Liver Transplantation -- Patient Selection -- Evaluation of Candidates for Liver Transplantation -- Liver Transplantation in Patients with Cirrhosis and Renal Failure -- Liver Transplantation in HIV-Positive Patients -- Conclusions -- References -- Part 2: Complications of Cirrhosis -- Chapter 9: Acute-on-Chronic Liver Failure -- Introduction and Definitions -- Epidemiology -- Pathophysiology -- Management and Prognosis -- Conclusions -- References -- Chapter 10: Hepatocellular Carcinoma -- Introduction -- Clinical Features -- Surveillance of HCC -- Diagnosis and Staging -- Treatment -- Conclusions -- References -- Chapter 11: Hepatic Encephalopathy -- Introduction -- Definition -- Clinical Manifestation -- Epidemiology -- Diagnostic Tools and Differential Diagnosis -- Diagnosis of Minimal and Covert HE -- Etiology and Pathogenesis -- Treatment -- Prophylaxis -- References -- Chapter 12: Malnutrition and Nutritional Support -- Introduction -- Etiologies of Malnutrition in Cirrhosis -- Nutritional Assessment in Cirrhosis -- Prevalence of Malnutrition in Cirrhosis -- Nutritional Support in Patients with Cirrhosis -- Conclusions -- References -- Chapter 13: Varices, Portal Hypertensive Gastropathy and GAVE -- Variceal Bleeding -- Portal Hypertensive Gastropathy -- Gastric Antral Vascular Ectasia -- Conclusions -- References -- Chapter 14: Ascites -- Andrés Cárdenas,1 Isabel Graupera,2 and Pere Ginès2 -- GI Unit, Hospital Clínic and University of Barcelona, Institut d'Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Ciber de Enfermedades Hepaticas y Digestivas (CIBERHED)
Liver Unit, Hospital Clínic and University of Barcelona, Institut d'Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Ciber de Enfermedades Hepaticas y Digestivas (CIBERHED), Instituto Reina Sofía de Investigación Nefrológica (IRSIN) Barcelona Spain -- Cirrhosis is the twelfth leading cause of mortality in the United States, accounting for nearly 32 000 deaths in 2010 [1]. Ascites is the most common complication of cirrhosis resulting in poor quality of life, high risk of development of other complications, increased morbidity and mortality associated with surgical interventions, and poor long-term outcome [2-6]. Cirrhotic patients with first onset ascites have survival rates of 85% at 1 year and 56% at 5 years without liver transplantation [3 -- The practical management of ascites involves a proper evaluation of the patient with a thorough history and physical examination. In addition, complete laboratory, ascitic fluid, radiologic, endoscopic, and, in some cases, histologic tests should be performed. One of the most important steps in the initial assessment of patients with ascites is referral of appropriate candidates for liver transplantation as this offers a definitive cure of cirrhosis and its complications. -- Taking proper care of patients with ascites can be challenging because they are prone to complications such as spontaneous bacterial peritonitis (SBP), hypervolemic hyponatremia, hepatic hydrothorax, hepatorenal syndrome (HRS) and hepatocellular carcinoma, bleeding from esophageal or gastric varices, and hepatic encephalopathy. While the initial management of uncomplicated ascites with low sodium diet and diuretic treatment is straightforward in the majority of patients, there is a group of pati -- Chapter 15: Spontaneous Bacterial Peritonitis and Other Infections -- General Considerations -- The Diagnostic Approach
Spontaneous Bacterial Peritonitis -- Other Infections -- Prevention of Organ Failure -- Management of Organ Failure, Severe Sepsis, and Septic Shock -- Prevention of Bacterial Infection in Cirrhosis -- Conclusions -- References -- Chapter 16: Hepatorenal Syndrome and Acute Kidney Injury -- Hepatorenal Syndrome -- Acute Kidney Injury -- Conclusions -- References -- Chapter 17: The Hepatopulmonary Syndrome -- Introduction -- Definition -- Epidemiology -- Pathogenesis -- Clinical Features -- Diagnosis -- Natural History and Treatment -- Conclusions -- References -- Chapter 18: Hyponatremia and Other Electrolyte/Ion Disorders -- Hyponatremia -- Disorders of Potassium Homeostasis -- Disorders of Magnesium and Phosphate Homeostasis -- References -- Chapter 19: Portopulmonary Hypertension1 -- Introduction -- Definition -- Screening -- Epidemiology and Natural History -- Etiology and Pathogenetic Mechanisms -- Clinical Manifestations -- Medical Treatment -- Liver Transplantation -- Conclusions -- References -- Chapter 20: Cirrhotic Cardiomyopathy -- Introduction -- Pathology -- Pathophysiology -- Clinical Features -- Systolic Dysfunction -- Diastolic Dysfunction -- Prolongation of the QT Interval -- Diagnosis -- Management -- Prognosis -- References -- Chapter 21: Adrenal Insufficiency -- Introduction -- Background -- Physiology of the Hypothalamic-Pituitary-Adrenal Axis -- Relative Adrenal Insufficiency and Critical Illness-Related Corticosteroid Insufficiency -- Pathophysiology -- Adrenal Insufficiency and Liver Disease -- Prevalence and Clinical Relevance of Adrenal Insufficiency in Liver Disease -- RAI/CIRCI in Critically Ill Patients with Liver Disease -- Prevalence of Adrenal Insufficiency in Stable Cirrhosis -- Adrenal Function Testing in Cirrhosis - Which Test?
Adrenal Function and the Complications of Cirrhosis - who should be Tested and who should be Treated? -- Adrenal Insufficiency and Liver Transplantation -- Conclusions -- References -- Chapter 22: Coagulopathy and Clotting Disorders -- Introduction -- Hemostatic Factors -- Anticoagulant Factors -- Disorders of the Fibrinolytic System -- Assessment of the Risk of Thrombosis and Anticoagulation -- Assessment of the Risk of Bleeding -- Invasive Procedures -- Coagulation during Infection and Sepsis -- References -- Chapter 23: Agents and Drugs: Precautions in Patients with Cirrhosis -- Introduction -- Impaired Liver Function and Drug Biotransformation -- Acetaminophen/Paracetamol -- Nonsteroidal Anti-Inflammatory Drugs -- Antirheumatic Agents -- Opiate Replacement Therapy -- Antituberculosis Agents -- Antibiotics -- Drugs to Treat HIV Infection -- Drugs Acting on the Central Nervous System -- Miscellaneous Agents -- References -- Chapter 24: Changing Outcomes with Antiviral or Antifibrotic Therapies -- Introduction -- HBV-Related Cirrhosis -- HCV-Related Cirrhosis -- Antifibrotic Therapy -- References -- Chapter 25: Bone Disorders -- Introduction -- Osteonecrosis -- Osteomalacia -- Vitamin D Deficiency -- Osteoporosis -- Conclusions -- References -- Chapter 26: Pruritus -- Pathogenesis of the Pruritus of Cholestasis -- The Approach to the Patient with the Pruritus of Cholestasis -- Conclusions -- References -- Chapter 27: Quality of Life and Symptom Management -- Introduction -- Measuring Functional Ability and Quality of Life -- Causes for Impaired Quality of Life -- Is Quality of Life Really Impaired in Patients with Liver Disease? -- Quality of Life and Patients with Hepatitis C -- Specific Symptoms or Clinical Syndromes Affecting Quality of Life -- General Approach to Evaluation and Diagnosis -- General Management Approach
Treating the Underlying Liver Disease
Cirrhosis: a practical guide to management provides gastroenterologists and hepatologists with an up-to-date clinical guide presenting the very best evidence-based practice in the diagnosis, treatment and management of liver cirrhosis and its many complications.  Designed to offer practical guidance at all times, it provides doctors with an extremely useful tool in the clinical setting, with each chapter featuring diagnostic/management algorithms, key points and other pedagogic features. Divided into 2 parts, a diagnosis and pathophysiology section and a management of complications section, key topics include: - Diagnostic laboratory tests - Diagnostic imaging modalities - Acute-on chronic liver failure - Agents and drugs to avoid - End stage liver failure: liver transplant evaluation - Hepatocellular carcinoma Aimed at the specialist, as well as the practicing trainee at the top-end of specialty training, the emphasis throughout is on providing optimum clinical management guidance most relevant to practicing hepatologists and gastroenterologists, and is an invaluable guide to this increasingly common condition
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Lee, Samuel S. Cirrhosis : A Practical Guide to Management New York : John Wiley & Sons, Incorporated,c2015 9781118274828
Subject Liver Cirrhosis - diagnosis
Electronic books
Alt Author Moreau, Richard
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