LEADER 00000nam a22004933i 4500 
001    EBC477240 
003    MiAaPQ 
005    20200713055140.0 
006    m     o  d |       
007    cr cnu|||||||| 
008    200713s2009    xx      o     ||||0 eng d 
020    9789812832665|q(electronic bk.) 
020    |z9789812832641 
035    (MiAaPQ)EBC477240 
035    (Au-PeEL)EBL477240 
035    (CaPaEBR)ebr10361573 
035    (CaONFJC)MIL244157 
035    (OCoLC)557659721 
040    MiAaPQ|beng|erda|epn|cMiAaPQ|dMiAaPQ 
050  4 QD381.M625 2009 
082 0  572 
100 1  Riccio, Paolo 
245 10 Molecules :|bNucleation, Aggregation and Crystallization -
       Beyond Medical and Other Implications 
264  1 Singapore :|bWorld Scientific Publishing Company,|c2009 
264  4 |c©2009 
300    1 online resource (365 pages) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
505 0  Contents -- Preface -- 1. From Kuru to Nucleation, 
       Aggregation, Polymerization and Crystallization in Biology
       and Medicine D. Carleton Gajdusek -- Molecular Casting -- 
       Infectious amyloid nucleants -- Can we preserve biological
       specificity of antibodies, antigens, pheronemes, receptors,
       transmitters, ion channels and enzymes in organic 
       molecular casts or atomic moulds? -- Dermatoglyphic 
       preserving of biological specificity -- Fossils show 
       accurate speciation in paleobotany and paleozoology -- 
       Osmium shading in electron microscopy reveals details of 
       molecular structure at nanometric distances -- Mineral 
       nucleants for crystal growth in outer space -- What makes 
       a diamond hold together? -- Twinning of minerals -- 
       Industrial viruses and "ice nine" -- Amyloid enhancing 
       factors are scrapie infectious amyloid nucleants -- Any β-
       pleated polymeric assembly as a two-dimensional  sheet or 
       as a fibril may act as a heteronucleant for  different 
       amyloidogenic proteins -- Synthesis of prion-like 
       infectious nucleants -- Biological macromolecules all 
       interact strongly with SiO2, the most common solid mineral
       on the surface of Earth. Montmorillonite clay deposits 
       cause delayed neurodegenerative diseases -- Nucleation is 
       speleology -- Nucleation in extragalactic space -- 
       References -- 2. Gels Mimicking Antibodies in Their 
       Selective Recognition of Proteins and Its Potential Use 
       for Protein Crystallization Jan Sedzik, Nasim Ghasemzadeh,
       Fred Nyberg and Stellan Hjertén -- Introduction -- 
       Experimental Details -- Materials -- Preparation of a 
       ribonuclease-specific gel -- Preparation of a gel for 
       specific adsorption of human growth hormone -- Can a bed 
       be designed with selectivity for more than one protein? --
       The degree of selectivity of the adsorption -- Selective 
       bed with higher flow rate -- Results and Discussion -- The
       selectivity of the artificial gel antibodies 
505 8  Do some protein molecules become attached covalently to 
       the gel matrix? -- What conclusions can be drawn from the 
       finding that (bio-)affinity methods do not always give the
       selectivity theoretically expected? -- Classification of 
       chromatographic techniques in terms of the number of bonds
       between the solute and the stationary phase and the 
       strength of these bonds -- Some comments on the mechanism 
       of selective recognition -- Artificial gel antibodies for 
       detection of biomarkers -- Selectivity, protein capacity 
       and imprinting of bioparticles -- Potential applications -
       - The design of a chromatographic bed for removal of 
       impurifying proteins ("negative purification") -- 
       Forthcoming studies -- Conclusions -- Acknowledgments -- 
       References -- 3. Bioinformatics of Myelin Membrane 
       Proteins Gunnar von Heijne and Jan Sedzik -- Introduction 
       -- Definition of Bioinformatics -- The Basis of Biological
       Membranes -- Biological Membranes - Protein/Lipid Ratio --
       Basic Bioinformatics -- Focus on the Myelin Membrane -- 
       Water Soluble Versus Integral Myelin Proteins -- Myelin 
       basic protein -- P2 protein -- P0 protein -- PMP22 protein
       -- PLP protein -- MAG -- MOG -- Summary -- Acknowledgment 
       -- References -- 4. Biomolecular Mass Spectrometry: 
       Applications to Proteins and Peptides Leopold L. Ilag and 
       Gianluca Maddalo -- Introduction -- Proteomics -- 
       Techniques and strategies -- Peptide mass fingerprinting -
       - De novo sequencing -- Post-translational and Chemical 
       Modifications -- MALDI Imaging -- MS in structural biology
       -- Fibroblast growth factor (FGF) and fibroblast growth 
       factor receptor (FGFR) -- RNA polymerase -- Ribosome -- 
       Protein-lipid interactions -- Conclusion -- 
       Acknowledgments -- References -- 5. Myelin: A One-
       Dimensional Biological "Crystal" for X-Ray and Neutron 
       Scattering Hideyo Inouye and Daniel A. Kirschner -- 
       Introduction 
505 8  Electron Density Profile on an Absolute Scale -- Chemical 
       Interpretation of the Electron Density and Neutron 
       Scattering Length Density Profiles -- Method -- Model 
       calculation -- Conclusion -- Acknowledgments -- References
       -- 6. Two-Dimensional Crystallization of Biological 
       Macromolecules Hans Hebert -- Introduction -- Why Two-
       Dimensional Crystals? -- Electron Crystallography: Initial
       Characterization -- How to Make 2D Crystals of Proteins --
       Membrane proteins -- Soluble proteins -- Properties of 2-D
       crystals -- Symmetry -- Size -- Order -- Flatness -- 
       Stacking, multilayers -- Electron Crystallography: Data 
       Collection and Processing -- Specimen preparation and 
       temperature -- Electron diffraction -- Images -- Data 
       processing -- 2D or 3D Crystallization? -- Summary -- 
       Acknowledgments -- References -- 7. Crystallization of 
       Proteins: Principles and Methods Lata Govada -- 
       Introduction -- Principles of Crystallization -- The 
       crystallization phase diagram -- The solubility curve -- 
       The supersolubility curve -- Precipitation zone -- 
       Nucleation zone -- Metastable zone -- Construction of 
       Supersolubility Curve -- Crystallization Methodologies -- 
       Batch crystallization -- Modified microbatch -- Diffusion 
       methods -- Vapor diffusion -- Hanging drop -- Sitting drop
       -- Sandwich drop -- Liquid-liquid interface diffusion -- 
       Granada crystallization box® (GCB) -- Dialysis -- Bulk 
       dialysis -- Microdialysis -- Conclusions -- 
       Acknowledgments -- References -- 8. The Role of Oil in 
       Protein Crystallization Naomi E. Chayen -- Introduction --
       The Microbatch Techniques -- The mechanism of 
       crystallization under oil -- The application of oil to 
       improve vapour diffusion experiments -- The contribution 
       of oil to the control of heterogeneous nucleation -- 
       Cleanliness of trials -- Effect of surface contact -- 
       Protection of crystallization samples and crystals by the 
       oil 
505 8  Limitation of Crystallizing Under Oil -- Application of 
       organic molecules as precipitants and/or additives -- 
       Harvesting and mounting of crystals -- Crystallization of 
       membrane proteins under oil -- Summary -- Acknowledgment -
       - References -- 9. Introduction to Crystallization of Fine
       Chemicals and Pharmaceuticals Åke C. Rasmuson -- 
       Introduction -- Fundamentals -- Solubility and 
       Supersaturation -- Nucleation -- Crystal Growth -- The 
       Product -- Productivity -- Solid phase -- Particle size --
       Crystal shape -- Product purity -- The Process -- The role
       of agitation -- Control of the product crystal mean size -
       - Conclusions -- References -- 10. Myelin Basic Protein, A
       Saucy Molecule With High Responsiveness to the Environment
       or Just an Unusual Membrane Protein? Paolo Riccio -- 
       Introduction -- Myelin Basic Protein: What Is It and What 
       Does It Do? -- The IUPs -- MBP Ligands and Functions -- 
       Post-Translational Modifications of MBP -- Is MBP a 
       Natively Unfolded Protein? -- The absence of structure in 
       the acid-extracted molecule -- MBP as a membrane protein: 
       The discovery of lipid-bound MBP -- Partitioning of MBP in
       the Myelin Membrane -- Incorporation of myelin basic 
       protein in liposomes made of myelin lipids -- Concluding 
       Remarks -- Acknowledgments -- References -- 11. The Use of
       a Magnetic Field and Magnetic Force as a Means to Improve 
       the Quality of Protein Crystals Mitsuo Ataka -- 
       Introduction -- Theoretical Background -- Magnetic field 
       orientation -- Magnetic force -- Technical Background -- 
       Generation of magnetic fields by various magnets -- 
       Superconducting magnets for supplying uniform magnetic 
       force -- Modes of operation of various magnets -- 
       Historical Background -- Our Studies on Magnetic 
       Orientation -- Protein crystals grown in a magnetic field 
       exhibit orientation -- Sedimenting crystals -- Other 
       Studies on Magnetic Orientation of Protein Crystals 
505 8  Other Uses of Magnetic Orientation -- Other Possible 
       Mechanisms Through Which Homogeneous Magnetic Fields May 
       Contribute to Quality Improvement -- Studies on Crystal 
       Perfection in Homogeneous Magnetic Fields -- Magnetic 
       Force -- Our studies on the use of a magnetic force -- 
       Convection Suppression or Damping in the Presence of 
       Magnetic Force -- Summary -- References -- 12. Interactive
       Crystallomic Jan Sedzik -- Introduction -- Experimental 
       Procedure - An Example -- Pre-crystallization assumptions 
       -- Chemicals and crystallization set-up -- Rationale and 
       design of the crystallization trials -- Algorithm -- 
       Results -- Discussion -- Summary -- Acknowledgments -- 
       References -- 13. Virtual Molecule: P0 Myelin 
       Glycoprotein. I. Homology Modeling and Prediction of the 
       Secondary and Tertiary Structure Jan Pawel Jastrzebski and
       Jan Sedzik -- Introduction -- Methods and Tools for 
       Homology Prediction -- Amino Acid Sequence - A Basic Input
       for Modeling -- Construction and Analysis of a Three-
       Dimensional Atomic Model of P0 Glycoprotein -- The P0 
       extracellular domain - Soluble part -- The P0 
       transmembrane segment is 21 amino residues long -- The P0 
       intracellular part -- Theoretical model of P0 -- 
       Hydrophobicity and Electrostatic Potential of P0 Protein -
       - Structural Effects of Breaking the Disulfide Bridge -- 
       Medical Implications - Autoimmune Epitopes of Myelin P0 
       Protein -- Summary and Discussion -- Acknowledgments -- 
       References -- 14. In meso Approaches to Membrane Protein 
       Crystallization Valentin I. Gordeliy and Ekaterina S. 
       Moiseeva -- Introduction -- Membrane Protein 
       Crystallization: A Standard Approach -- In mesoMembrane 
       Protein Crystallization -- Cubic phase crystallization -- 
       Crystallization in the sponge phase -- Crystallization 
       from vesicles -- Crystallization from bicelles -- Towards 
       a General Method of Membrane Protein Crystallization -- 
       Summary 
505 8  Acknowledgments 
520    Key Features:Suitable as an advanced text for graduate 
       students and non-experts alikeContains sufficiently 
       detailed text to capture the interest of curious 
       readersServes as an introduction to explore the research 
       literature in the fieldIncludes contributions by prominent
       authors such as Nobel Laureate Carlton Gajdusek 
588    Description based on publisher supplied metadata and other
       sources 
590    Electronic reproduction. Ann Arbor, Michigan : ProQuest 
       Ebook Central, 2020. Available via World Wide Web. Access 
       may be limited to ProQuest Ebook Central affiliated 
       libraries 
650  0 Macromolecules.;Proteins.;Nucleation.;Aggregation 
       (Chemistry);Crystallization 
655  4 Electronic books 
700 1  Sedzik, Jan 
776 08 |iPrint version:|aRiccio, Paolo|tMolecules: Nucleation, 
       Aggregation And Crystallization: Beyond Medical And Other 
       Implications|dSingapore : World Scientific Publishing 
       Company,c2009|z9789812832641 
856 40 |uhttps://ebookcentral.proquest.com/lib/sinciatw/
       detail.action?docID=477240|zClick to View