LEADER 00000cam  2200469Ii 4500 
001    1024081468 
003    OCoLC 
005    20180425000002.0 
006    m     o  d         
007    cr |n||||||||| 
008    180223s2017    maua    o     000 0 eng d 
020    9780128127643 
020    0128127643 
035    (OCoLC)1024081468 
040    MEU|beng|erda|cMEU|dOCLCO|dOCLCF|dOCLCQ|dOCLCO|dAS 
050  4 RC346|b.E58 2017eb 
245 00 Environmental Factors in Neurodegenerative Diseases /
       |cedited by Michael Aschner, Lucio G. Costa 
264  1 Cambridge :|bAcademic Press,|c2017 
300    1 online resource (xi, 278 pages :|billustrations) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
505 8  2.3. Exposure Assessment and Studies of Specific 
       Pesticides2.3.1. Rotenone; 2.3.2. Paraquat; 2.3.3. 
       Organochlorine Pesticides; 2.3.4. Specific 
       Organochlorines; 2.3.5. Other Pesticide Associations; 2.4.
       Studies of Interaction Between Genes and Environment; 3. 
       Experimental Evidence; 3.1. Pesticides and Nigrostriatal 
       Degeneration: Rotenone and Paraquat; 3.1.1. Rotenone; 
       3.1.2. Paraquat; 3.2. Rotenone, Paraquat, and [alpha]-
       Synuclein; 3.2.1. [alpha]-Synuclein and Rotenone; 3.2.2. 
       [alpha]-Synuclein and Paraquat; 3.3. Additional Features 
       of PD-Relevant Pesticides 
505 0  Front Cover; Environmental Factors in Neurodegenerative 
       Diseases; Copyright; Contents; Contributors; Preface; 
       Chapter One: Traffic-Related Air Pollution and 
       Neurodegenerative Diseases: Epidemiological and 
       Experimental Evidence, and ... ; 1. Introduction; 2. The 
       CNS as a Target for Air Pollution Toxicity; 2.1. 
       Neurotoxicity in Adults: Epidemiological and Animal 
       Studies; 2.2. Developmental Neurotoxicity; 3. Air 
       Pollution and Neurodegenerative Diseases; 3.1. Air 
       Pollution and PD; 3.2. Air Pollution and Amyotrophic 
       Lateral Sclerosis; 3.3. Air Pollution and Multiple 
       Sclerosis 
505 8  3.4. Air Pollution and Alzheimer's Disease and Other 
       Dementias4. Possible Mechanisms Linking Air Pollution to 
       Neurodegeneration; 4.1. Adult Neurogenesis; 4.2. 
       MicroRNAs; 4.3. Telomere Length; 4.4. Reelin; 4.5. 
       Glutamate; 5. Conclusion and Research Needs; 
       Acknowledgments; References; Further Reading; Chapter Two:
       The Catecholaminergic Neurotransmitter System in 
       Methylmercury-Induced Neurotoxicity; 1. Introduction; 2. 
       The Catecholaminergic Neurotransmitter System: General 
       Aspects; 3. Catecholamines in Neurological and 
       Neuropsychiatric Disorders 
505 8  4. The Catecholaminergic Neurotransmitter System as a 
       Potential Target of Neurotoxicants and Related 
       Consequences5. Methylmercury: General Aspects and Major 
       Mechanisms of Neurotoxicity; 6. Methylmercury-Mediated 
       Catecholaminergic Toxicity; 6.1. Dopamine; 6.2. 
       Epinephrine; 7. Concluding Remarks; Acknowledgments; 
       References; Further Reading; Chapter Three: Pesticides and
       Parkinson's Disease: Current Experimental and 
       Epidemiological Evidence; 1. Introduction; 2. 
       Epidemiological Evidence; 2.1. Studies of Occupations; 
       2.2. Studies of Exposure to Pesticides 
505 8  3.3.1. Long-Lasting Effects and Toxicant 
       Interactions3.3.2. Gender Differences and Genetic 
       Determinants of Pesticide Neurotoxicity; 3.3.3. Pesticide-
       Induced Transcriptional Alterations; 4. Final Remarks; 
       Acknowledgment; References; Chapter Four: Metals and 
       Circadian Rhythms; 1. Introduction; 2. Manganese; 3. 
       Copper; 4. Zinc; 5. Lead; 6. Mercury; 7. Aluminum; 8. 
       Conclusion; Acknowledgments; References; Chapter Five: 
       Aluminum and Neurodegenerative Diseases; 1. Introduction; 
       2. Growing Bioavailability of Aluminum in the Environment 
520    Environmental Factors in Neurodegenerative Diseases, 
       Volume One addresses contemporary advances in 
       neurotoxicology, with thematic volumes providing 
       authoritative review articles on key issues in the field. 
       Updates in this new volume include chapters on Air 
       pollution and neurodegenerative diseases, Mercury and 
       Parkinson's disease, Pesticides and PD: current evidence, 
       Aluminum and neurodegeneration, Microglia and 
       neurodegeneration, Dietary factors, Mitochondria in 
       neurodegeneration, and Manganese and neurodegeneration. 
       Edited by leading experts, volumes are designed as in-
       depth overviews of the latest topic developments that 
       analyze the effect of varied chemical agents on the 
       nervous system. It is an essential resource for 
       researchers and graduate students alike 
546    Text in English 
650  0 Nervous system|xDegeneration 
650  0 Nervous system|xDiseases|xEnvironmental aspects 
650  0 Neurotoxicology 
650  2 Neurodegenerative Diseases 
655  4 Electronic books 
700 1  Aschner, Michael,|d1955-|eeditor 
700 1  Costa, Lucio G.,|d1954-|eeditor 
776 08 |iPrint version:|z9780128127643|z0128127643
       |w(OCoLC)985078857 
830  0 Advances in neurotoxicology ;|v1 
856 40 |uhttp://www.sciencedirect.com/science/bookseries/24687480
       /1|zeBook(ScienceDirect)