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Author Cole, Richard B
Title Electrospray and MALDI Mass Spectrometry : Fundamentals, Instrumentation, Practicalities, and Biological Applications
Imprint Hoboken : John Wiley & Sons, Incorporated, 2010
book jacket
Edition 2nd ed
Descript 1 online resource (896 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Intro -- Electrospray and MALDI Mass Spectrometry -- Contents -- Foreword: Desorption Ionization and Spray Ionization: Connections and Progress -- Foreword to the First Edition -- Preface -- Contributors -- Part I Fundamentals of ES -- 1. On the Mechanism of Electrospray Ionization Mass Spectrometry (ESIMS) -- 2. Selectivity in Electrospray Ionization Mass Spectrometry -- 3. Electrochemistry of the Electrospray Ion Source -- 4. ESI Source Design -- Part II Fundamentals of MALDI -- 5. MALDI Ionization Mechanisms: an Overview -- 6. The Development of Matrix-Assisted Laser Desorption/Ionization Sources -- 7. A Comparison of MALDI Matrices -- 8. MALDI Imaging Mass Spectrometry -- Part III ES and MALDI Coupling to Mass Spectrometry Instrumentation -- 9. Coupling ESI and MALDI Sources to the Quadrupole Mass Filter, Quadrupole Ion Trap, Linear Quadrupole Ion Trap, and Orbitrap Mass Analyzers -- 10. Time-of-Flight Mass Spectrometry -- 11. Fourier Transform Ion Cyclotron Resonance and Magnetic Sector Analyzers for ESI and MALDI -- 12. Ion Mobility-Mass Spectrometry -- Part IV Practical Aspects of ES and MALDI -- 13. ESI, APCI, and MALDI A Comparison of the Central Analytical Figures of Merit: Sensitivity, Reproducibility, and Speed -- 14. Charge State Distributions in Electrospray and MALDI -- 15. Probing Noncovalent Interactions by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization -- 16. Ion Activation Methods for Tandem Mass Spectrometry -- 17. Dissociation of Even-Electron Ions -- Part V Biological Applications of ES and MALDI -- 18. The Role of Mass Spectrometry for Peptide, Protein, and Proteome Characterization -- 19. Carbohydrate Analysis by ESI and MALDI -- 20. Applications of ESI and MALDI to Lipid Analysis -- 21. In Vitro ADME Profiling and Pharmacokinetic Screening in Drug Discovery -- Index
Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra Part E,
Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Cole, Richard B. Electrospray and MALDI Mass Spectrometry : Fundamentals, Instrumentation, Practicalities, and Biological Applications Hoboken : John Wiley & Sons, Incorporated,c2010 9780470588901
Subject Electrospray ionization mass spectrometry.;Biomolecules -- Analysis
Electronic books
Alt Author Cole, Richard B
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