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035    (MiAaPQ)EBC818661 
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050  4 SF768 -- .S97 2011eb 
082 0  636.089/2 
100 1  Woelders, Henri 
245 10 Systems Biology and Livestock Science 
250    1st ed 
264  1 Hoboken :|bJohn Wiley & Sons, Incorporated,|c2011 
264  4 |c©2011 
300    1 online resource (756 pages) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
505 0  Cover -- Title Page -- Copyright -- List of Contributors -
       - Preface -- From livestock production to biological 
       science: from systems biology to livestock production -- 
       Chapter 1: Introduction to Systems Biology for Animal 
       Scientists -- Why Should Animal Scientists Be Interested 
       in Learning About Systems Biology? -- What Is Systems 
       Biology? -- A Systems Biology Paradigm: The Progress in 
       Analysis of the Mammalian Immune Response Network -- What 
       Parts of Systems Biology Are in Use in Animal Science 
       Today? -- Further Reading -- Partial Listing of Online 
       Resources for Systems Biology -- Web sites -- 
       Acknowledgments -- Chapter 2: Modeling Approaches in 
       Systems Biology, Including Silicon Cell Models -- What Is 
       Systems Biology -- Various Systems Biological Models -- 
       Three Strategies to Build a Model: Top-Down, Middle-Out, 
       and Bottom-Up -- Perspectives of Silicon Cell Models: 
       Advantages and Concerns -- Use of Systems Biological 
       Models, Including Silicon Cell Models -- Acknowledgments -
       - Chapter 3: The IUPS Physiome Project: A Worldwide 
       Systems Biology Initiative -- Introduction -- Fundamental 
       Principles of the Physiome Project -- The Framework and 
       Strategies of the Physiome Project -- The Current Status 
       of Physiome Modeling -- Conclusions and Future Directions 
       -- Acknowledgments -- Chapter 4: Systems Biology in 
       Livestock Health and Disease -- Introduction -- Defining 
       Systems Biology in the Medical Context -- Establishing the
       Need for Systems Biology Approaches in Human and 
       Veterinary Medicine -- Systems Biology and Personalized 
       Healthcare in Human Medicine -- Areas of Application of 
       Systems Biology to Human Medicine -- Barriers to 
       Implementing Personalized Medicine in Human Medical 
       Practice -- Systems Biology Techniques -- Novel 
       Technologies -- Personalized Medicine Versus Livestock 
       Population Health -- Molecular Diagnostics 
505 8  Using Systems Biology to Understand Host-Pathogen 
       Interactions -- Molecular Epidemiology -- Example of 
       Systems Biology Applications in Livestock Health: Mastitis
       in Dairy Cattle -- Conclusion: Challenges of Applying 
       Systems Biology Concepts and Techniques to Livestock 
       Health Management -- Chapter 5: Systems Biology of Host-
       Food-Microbe Interactions in the Mammalian Gut -- The 
       Gastrointestinal Tract and Body Homeostasis -- The Need 
       for Systems Approaches to Study Diet-Host-Microbiota 
       Interactions -- The Gastrointestinal (GI) Tract -- Energy 
       Homeostasis -- Signaling and Hormone Homeostasis -- 
       Homeostasis of Tolerance and Immunity -- Nutritional 
       Challenges -- The Intestinal Microbiota -- Integrated 
       Modeling Approaches -- Challenges Ahead -- Conclusions -- 
       Chapter 6: From Visual Biological Models Toward 
       Mathematical Models of the Biology of Complex Traits -- 
       Introduction -- Generation of a Biological Model -- 
       Association Studies Relating the Expression Levels of 
       Genes or Proteins to Quantitative Traits -- Bioinformatics
       Toward Systems Biology: Biological Models Toward 
       Mathematical Models -- Future Expectations -- 
       Acknowledgments -- Chapter 7: Molecular Networks as 
       Sensors and Drivers of Uterine Receptivity in Livestock --
       Introduction -- Transcriptome Analysis as a Holistic 
       Approach for the Study of Cellular Changes at the 
       Molecular Level -- Resources for Functional Gene 
       Annotation and Gene/Protein Interactions and Corresponding
       Analysis Tools -- Identification of Biological Themes 
       Related to Endometrial Remodeling and Receptivity in a 
       Microarray Study of Bovine Endometrium During the Estrous 
       Cycle -- Correlation of Gene Expression Data and Data from
       Genome-Wide Association Studies (GWAS) Links Differential 
       Gene Expression with Phenotypes Related to Fertility 
505 8  Identification of Genes Involved in Preparation of the 
       Bovine Endometrium for Embryo Implantation -- Analysis of 
       Gene Expression in Endometrium During the Preimplantation 
       Phase in Porcine Endometrium -- Analysis of Gene 
       Expression in Endometrium During the Preimplantation Phase
       in Equine Endometrium -- Comparison of Gene Expression 
       Datasets from Different Mammalian Species -- 
       Identification of Fertility-Related Genes by the Analysis 
       of Pathological Conditions -- Strategies and Approaches to
       Obtain Deeper Insights into and Better Understanding of 
       the Processes Related to Establishment and Maintenance of 
       Pregnancy -- Chapter 8: Modeling Approaches to Link 
       Various Levels of Organization in Animal Physiology -- 
       Introduction -- Levels of Organization -- Modeling 
       Approaches -- Some Examples of Physiological Aspects -- 
       Implications and Perspectives -- Acknowledgments -- 
       Chapter 9: Systems Biology and Animal Nutrition: Insights 
       from the Dairy Cow During Growth and the Lactation Cycle -
       - Introduction -- The Peripartal Dairy Cow as a Model for 
       Whole-Animal Systems Biology -- The Mammary Gland as a 
       Unique System -- Intertissue Cross Talk During Prepubertal
       Bovine Mammary Development -- Effect of Prepartal Nutrient
       and Energy Intake on Dairy Cow Adipose Tissue -- Effect of
       Prepartal Nutrient and Energy Intake on Dairy Cow Liver --
       Dietary Lipid Supplementation, Ruminal Metabolism, and the
       Mammary Gland Transcriptome -- Perspectives -- 
       Acknowledgments -- Chapter 10: Host-Pathogen Interactions 
       -- Introduction -- Data Explosion and the Rationale for 
       Systems Biology Approaches -- Infection Biology -- 
       Complexity and Scales -- Mathematical Models -- 
       Interaction Models -- Conclusions -- Chapter 11: Systems 
       Biology in Livestock Science and Commercial Livestock 
       Business -- Introduction -- Expectations from Systems 
       Biology for Livestock Science and Industrial Innovations 
505 8  Conclusions -- Color plates -- Index 
520    Marinus F.W. te Pas is a Senior Research Scientist of 
       Genomics and Bioinformatics at the Animal Breeding and 
       Genomics Centre, Wageningen UR Livestock Research.   Henri
       Woelders is a Senior Research Scientist of Reproduction 
       and Fertility, Animal Breeding and Genomics Centre, 
       Wageningen UR Livestock Research.   André Bannink is a 
       Research Scientist in Animal Nutrition, Wageningen UR 
       Livestock Research 
588    Description based on publisher supplied metadata and other
590    Electronic reproduction. Ann Arbor, Michigan : ProQuest 
       Ebook Central, 2020. Available via World Wide Web. Access 
       may be limited to ProQuest Ebook Central affiliated 
650  0 Veterinary physiology -- Computer 
       simulation.;Livestock.;Livestock -- Genetics -- Computer 
655  4 Electronic books 
700 1  Bannink, André 
700 1  te Pas, Marinus 
700 1  Bannink, André 
700 1  Bannink, André 
776 08 |iPrint version:|aWoelders, Henri|tSystems Biology and 
       Livestock Science|dHoboken : John Wiley & Sons, 
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