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050  4 QP277 .S74 2013 
082 0  618.17806 
100 1  Simón, Carlos 
245 10 Stem Cells in Reproductive Medicine :|bBasic Science and 
       Therapeutic Potential 
250    3rd ed 
264  1 New York :|bCambridge University Press,|c2013 
264  4 |c©2013 
300    1 online resource (216 pages) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
505 0  Intro -- Contents -- Contributors -- Preface -- 1 Genetics
       of germline formation -- Introduction -- Primordial germ-
       cell specification -- BMP4 -- BMP8B -- BMP2 -- FRAGILIS 
       and STELLA -- BLIMP1/PRDM1 -- PRDM14 -- PGC migration -- 
       KITL and c-KIT -- CXCL12 (SDF1), CXCR4, and E-cadherin -- 
       Sex determination -- Male germline formation -- SRY -- 
       SOX9 -- FGF9 and retinoic acid -- Female germline 
       formation -- WNT4 -- RSPO1 -- -catenin -- FOXL2 -- DAX1 --
       Retinoic acid -- Summary -- 2 Germ-cell differentiation 
       from pluripotent cells -- Introduction -- Germline 
       development in mammals -- Pregonadal development: 
       Specification, migration, and colonization of gonadal 
       crests -- Postgonadal development: Sex specification, 
       meiosis, and germ-cell maturation -- Stem cells as a 
       source of germ cells in vitro -- State of the art in germ-
       cell differentiation from mESCs -- State of the art in 
       germ-cell differentiation from hESCs and hiPSCs -- Main 
       challenges in germ-cell differentiation from pluripotent 
       cells -- Meiosis and its molecular regulation -- Post-
       transcriptional regulation by RNA-binding proteins and 
       small non-coding RNAs -- Concluding remarks and future 
       applications -- 3 The male gamete -- Introduction -- When 
       sperm cells are absent or fail -- Help wanted: Sperm 
       donation in the era of ICSI -- Clinical indications and 
       reproductive outcome -- What we learned from infertile 
       male sperm -- Male infertility and defective sperm 
       production -- Sperm defects related to sperm counts -- 
       Sperm defects unrelated to sperm counts -- Spermatogonial 
       stem cells to restore male fertility -- Molecular features
       of the functional spermatozoa -- Chromosomal content and 
       genetic status -- Imprinting -- Sperm DNA integrity -- 
       Oxidative stress defence in sperm -- Other molecular keys 
       in sperm physiology -- Oxygen consumption ability 
505 8  Information obtained from the application of massive 
       analysis techniques to sperm -- Sperm lipidic profile -- 
       Where are we now and where can we go: Conclusions -- 4 In 
       vitro production of functional sperm from neonatal mouse 
       testes -- Introduction -- Development of spermatogonial 
       transplantation technique -- In vitro multiplication of 
       spermatogonial stem cells -- In vitro spermatogenesis with
       organ culture method -- In vitro transplantation and 
       culture method (IVTC method) -- Cryopreservation of SSCs 
       and testis tissues -- Conclusion (future of clinical 
       applications) -- Acknowledgment -- 5 Adult stem-cell 
       population in the human testis -- Introduction -- SSC 
       progenitors populate the testes during fetal development -
       - SSCs balance between self-renewal and differentiation --
       The identity of SSCs is becoming elucidated -- SSCs are 
       housed in specialized niches -- SSCs can survive, 
       proliferate, and differentiate in vitro -- Spermatogonial 
       stem cells might be pluripotent -- Fertility restoration 
       after SSC loss -- Protocols have been developed to 
       cryopreserve SSCs -- Spermatogonial stem-cell 
       transplantation -- Testicular tissue grafting -- 
       Contaminating malignant cells need to be removed -- 
       Potential applications of SSCs in cell therapy -- SSCs as 
       a source for regenerative medicine -- SSCs at the basis of
       transgenerational therapy -- Conclusive thoughts -- 
       Acknowledgments -- 6 Meiotic recombination in human 
       oocytes -- Meiosis is a sexually dimorphic process -- The 
       basics of recombination: how crossovers are made -- 
       Measuring recombination -- Retrospective analyses of 
       recombination -- Linkage analysis -- Linkage 
       disequilibrium (LD) mapping -- Centromere mapping -- 
       Cytological analysis -- Analysis of crossover-associated 
       proteins -- Analysis of chiasmata -- Recombination in the 
       human female -- What we have learned from linkage studies 
505 8  Watching recombination as it happens: cytological studies 
       of pachytene oocytes -- Recombination and non-disjunction 
       -- Summary -- 7 Gene expression dynamics during human 
       embryonic development -- Introduction to human embryo 
       development and reprogramming -- Induced pluripotency -- 
       Significance of elucidating gene expression patterns 
       during pre-implantation development extends to pluripotent
       stem-cell biology -- Gene expression in the oocyte-to-
       embryo transition -- A survey of human embryo development 
       and gene expression -- Transcription profiling of the 
       human oocyte -- Cell cycle drivers and checkpoints in the 
       human eight-cell embryo -- Validation of gene expression 
       in a large set of oocytes and embryos at six developmental
       stages -- Analysis of single blastomeres from five- to 
       eight-cell embryos -- Correlating molecular data with 
       imaging data and developmental potential -- Imaging 
       parameters prospectively diagnose embryo fate in in vitro 
       experiments -- Embryo stage-specific gene expression -- 
       Individual blastomeres show cell autonomy -- The promise 
       of novel analytic tools -- Summary -- 8 Embryonic stem 
       cells from blastomeres maintaining embryo viability -- 
       Introduction -- ES cells via parthenogenesis -- 
       Transdifferentiation or reprogramming -- Single blastomere
       -derived ES cells -- 9 Gamete generation from stem cells 
       to avoid gamete donation and customized hESCs from 
       blastomeres as the cellular insurance for the newborn: 
       Will it ever be ethically acceptable? -- Introduction -- 
       Gamete generation to avoid gamete donation -- Gamete 
       generation from adult stem cells/iPS cells -- Gamete 
       generation from embryonic stem cells -- Moral status of 
       the human embryo -- Embryonic parents -- Informed consent 
       -- "Non-medical" applications -- Conclusion -- Customized 
       hESCs from blastomeres as the cellular insurance for the 
       newborn -- Avoiding embryo destruction 
505 8  The advantage of having an autologous stem-cell line in 
       storage -- Efficiency -- The alternatives -- Conclusion --
       10 Amniotic fluid and placental membranes: Uunexpected 
       sources of highly multipotent cells -- Introduction -- 
       Development of gestational stem cells -- Isolation and 
       characterization of amniotic fluid stem cells -- 
       Multipotency of amniotic fluid stem cells -- Osteocytes --
       Myocytes -- Adipocytes -- Endothelial cells -- Hepatocytes
       -- Chondrocytes -- Neuronal Cells -- Clinical application 
       of amniotic fluid stem cells -- Bone regeneration -- 
       Myocardial infarction -- Renal disease -- Neural 
       regeneration -- Lung regeneration -- Blood and immune 
       system regeneration -- Other clinical applications -- 
       Conclusion -- 11 Adult stem cells in the human endometrium
       -- Introduction -- Regenerative capacity of human 
       endometrium -- Endometrial stem/progenitor cell hypothesis
       -- Adult stem cells and their properties -- Endometrial 
       epithelial stem/progenitor cells -- Cell cloning studies -
       - Label-retaining cells -- Endometrial mesenchymal stromal
       /stem cells -- Cell cloning studies -- Multilineage 
       differentiation -- Label-retaining cells -- Side 
       population (SP) cells -- Endometrial reconstitution in 
       vivo -- Endometrial stem/progenitor cell markers -- Human 
       endometrial MSC markers -- Menstrual blood stem/progenitor
       cells -- Sources of endometrial stem/progenitor cells -- 
       Remnant fetal stem cells -- Circulating stem cells from 
       the bone marrow -- Endometrial stem/progenitor cells: 
       clinical perspective -- Cancer stem cells in endometrial 
       cancer -- Endometriosis -- Adenomyosis -- Tissue-
       engineering applications -- Conclusions and future 
       directions for human endometrial stem/progenitor cell 
       research -- Acknowledgments -- 12 In utero hematopoietic 
       cell transplantation -- Introduction -- Human clinical 
       experience -- Animal experience with IUHCTx 
505 8  Barriers to engraftment after IUHCTx -- Competitive 
       advantage -- Space in hematopoietic niches -- Rejection of
       transplanted cells -- Conclusions -- 13 Bone-marrow stroma
       : A source of mesenchymal stem cells for cell therapy -- 
       Mesenchymal stem cells (MSCs): general properties -- MSC 
       markers -- Immunological properties of MSCs -- In vivo 
       MSCs form a part of the cell microenvironment of bone 
       marrow -- Therapeutic applications of MSCs -- Capacity of 
       MSCs to differentiate towards various cell lineages -- 
       MSCs in the treatment of GvH disease -- MSCs for improving
       HSC engraftment and preventing GvHD -- Role of MSCs in 
       autoimmunity -- Conclusions and further directions -- 
       Acknowledgments -- 14 Dedifferentiation, 
       transdifferentiation, and reprogramming -- Introduction --
       Different roads to changing cell potency -- 
       Dedifferentiation -- Transdifferentiation -- Epigenetic 
       memory -- Concluding remarks -- 15 The metabolic framework
       of pluripotent stem cells and potential mechanisms of 
       regulation -- Introduction -- Metabolism and the 
       maintenance of pluripotency -- Metabolism and the 
       differentiation of pluripotent cells -- Reprogramming 
       energy metabolism -- Regulation of ES cell metabolism by 
       the culture environment -- Molecular regulation of 
       metabolic pathways in pluripotent stem cells -- 
       Conclusions -- Index 
520    Stem Cells in Reproductive Medicine is essential reading 
       for those keeping abreast of practical developments in 
       this rapidly moving field 
588    Description based on publisher supplied metadata and other
       sources 
590    Electronic reproduction. Ann Arbor, Michigan : ProQuest 
       Ebook Central, 2020. Available via World Wide Web. Access 
       may be limited to ProQuest Ebook Central affiliated 
       libraries 
650  0 Embryonic stem cells.;Reproductive health.;Human 
       reproductive technology 
655  4 Electronic books 
700 1  Pellicer, Antonio 
700 1  Reijo Pera, Renee 
776 08 |iPrint version:|aSimón, Carlos|tStem Cells in 
       Reproductive Medicine : Basic Science and Therapeutic 
       Potential|dNew York : Cambridge University Press,c2013
       |z9781107034471 
856 40 |uhttps://ebookcentral.proquest.com/lib/sinciatw/
       detail.action?docID=1303704|zClick to View