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020    9781681083858|q(electronic bk.) 
020    |z9781681083865 
035    (MiAaPQ)EBC4768355 
035    (Au-PeEL)EBL4768355 
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040    MiAaPQ|beng|erda|epn|cMiAaPQ|dMiAaPQ 
050  4 QH447.A584 2016 
082 0  572.86 
100 1  Lima, Manuela 
245 10 Anthropology 
250    1st ed 
264  1 Oak Park :|bBentham Science Publishers,|c2016 
264  4 |c©2016 
300    1 online resource (235 pages) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
490 1  Anthropology: Current and Future Developments ;|vv.2 
505 0  Intro -- CONTENTS -- FOREWORD -- PREFACE -- List of 
       Contributors -- Human Genomic Projects: Setting the Stage 
       for Genome-Scale Anthropological Studies -- 1.1. THE 
       FOUNDATION OF GENOMICS: OVERVIEW OF THE HUMAN GENOME 
       PROJECT -- 1.2. HUMAN GENOMIC PROJECTS: GENERAL 
       CHARACTERIZATION AND IMPACT ON BIOLOGICAL ANTHROPOLOGY -- 
       1.2.1. The HapMap Project -- 1.2.2. The ENCyclopedia of 
       DNA Elements (ENCODE) Project -- 1.2.3. National 
       Geographic's Genographic Project -- 1.2.4. 1000 Genomes 
       Project -- 1.2.5. The US National Institutes of Health 
       (NIH) Roadmap Epigenomics Project -- 1.2.6. Genotype-
       Tissue Expression (GTEx) Project -- 1.3. THE NEANDERTHAL 
       GENOME PROJECT: AN IN-DEPTH JOURNEY INTO OUR PAST -- 1.4. 
       GENOMICS OF OUR RELATIVES: THE NON-HUMAN PRIMATE GENOME 
       PROJECTS -- CONCLUDING REMARKS -- CONFLICT OF INTEREST -- 
       ACKNOWLEDGEMENTS -- REFERENCES -- Complete Mitochondrial 
       DNA through Massively Parallel Sequencing: Methodology and
       Applications -- 2.1. INTRODUCTION -- 2.2. MTDNA 
       CHARACTERISTICS AND APPLICATIONS -- 2.3. AMPLIFICATION 
       STRATEGIES -- 2.3.1. Long-range PCR -- 2.3.2. Low Template
       and Degraded Samples -- 2.3.3. Ancient mtDNA Studies -- 
       2.4. MPS PLATFORMS -- 2.4.1. Illumina MiSeqTM -- 2.4.2. 
       Ion Torrent Personal Genome Machine (PGM™) -- 2.4.3. 
       Platforms Comparisons -- 2.5. IMPLEMENTATION OF MPS IN THE
       ROUTINE RESEARCH AND DIAGNOSTIC LABORATORIES -- CONCLUDING
       REMARKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- 
       REFERENCES -- Somatic vs Germinal Mutations in 
       Mitochondrial DNA: Is There Any Relation with Human Health
       and Aging? -- 3.1. INTRODUCTION -- 3.2. MATERIAL AND 
       METHODS -- 3.2.1. Sample Selection -- 3.2.2. MtDNA 
       Analysis -- 3.2.3. Classification of mtDNA Heteroplasmy in
       Somatic or Germinal -- 3.2.4. In Silico Prediction of 
       Functional Impact of Mutations and Data Analysis -- 3.3. 
       RESULTS -- 3.3.1. Frequency and Nature of Heteroplasmy 
505 8  3.3.2. Functional Impact of Heteroplasmy -- 3.4. 
       DISCUSSION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- 
       REFERENCES -- Human Y Chromosome Mutation Rate: Problems 
       and Perspectives -- 4.1. INTRODUCTION -- 4.2. THE Y 
       CHROMOSOME -- 4.3. DATING THE TREE -- 4.4. MUTATION RATES 
       -- 4.4.1. de novo Mutation Rate -- 4.4.2. Evolutionary 
       Rate -- 4.4.3. Ancient DNA Based Rate -- 4.5. APPLICATION 
       TO TWO PUBLIC DATABASES -- 4.5.1. Comparing the Two 
       Databases -- CONCLUSIVE REMARKS -- CONFLICT OF INTEREST --
       ACKNOWLEDGEMENTS -- REFERENCES -- Genomics of Isolated 
       Populations: Inferences for Gene-Finding Studies -- 5.1. 
       GENETIC VARIATION AND DISEASE IN HUMAN POPULATIONS -- 5.2.
       HUMAN GENETIC ISOLATES: GENERAL CHARACTERISTICS -- 5.3. 
       THE USE OF POPULATION ISOLATES IN GENE FINDING STUDIES: 
       ADVANTAGES AND LIMITATIONS -- 5.4. THE GENOMIC ERA AND THE
       USE OF ISOLATED POPULATIONS FOR GENE FINDING -- CONCLUDING
       REMARKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- 
       REFERENCES -- Complex Human Phenotypes: The Interplay 
       between Genes and Environment -- 6.1. INTRODUCTION -- 6.2.
       TWIN STUDIES: DISENTANGLING THE INVOLVEMENT OF GENES AND 
       ENVIRONMENT IN COMPLEX TRAITS -- 6.2.1. Twinning in Human 
       Populations -- 6.2.2. Twin Studies -- 6.2.3. The 
       Heritability Concept -- 6.3. GENE-ENVIRONMENT INTERPLAY 
       MECHANISMS -- 6.3.1. Gene-Environment Interaction -- 
       6.3.1.1. Example 1: Gene-Environment Interaction in Mental
       Disorders: The Role of Childhood Maltreatment and MAOA 
       Gene -- 6.3.1.2. Example 2: Gene-Environment Interaction 
       in Obesity -- 6.3.2. Gene-Environment Correlation -- 
       6.3.2.1. Example 1: The Role of Both GxE Interaction and 
       Correlation in the Relationship between Cannabis and 
       Schizophrenia -- 6.3.2.2. Example 2: Gene-Environment 
       Correlation: Quantitative and Molecular Genetics Data on 
       the Role of Genetic Factors in Friendship Selection -- 
       CONCLUDING REMARKS -- CONFLICT OF INTEREST 
505 8  ACKNOWLEDGEMENTS -- REFERENCES -- Ancient DNA: From Single
       Words to Full Libraries in 30 Years -- 7.1. HISTORY OF 
       ANCIENT DNA ANALYSIS -- 7.2. ANCIENT DNA FEATURES AND 
       ENVIRONMENTAL FACTORS -- 7.2.1. Physical and Chemical 
       Agents Damaging DNA -- 7.2.2. Main Types of Damage -- 
       7.2.3. Contamination and Its Importance in a DNA Work -- 
       7.2.4. Reporting Contamination -- 7.2.5. Decontamination 
       Methodologies -- CONCLUDING REMARKS -- CONFLICT OF 
       INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Troubles and
       Efficiency of aDNA -- 8.1. AUTHENTICITY CRITERIA -- 8.1.1.
       Phylogenetic and Population Meaning: Refining the Criteria
       -- 8.1.2. Decontamination: Could it be Achieved? -- 8.2. 
       INHIBITION AND NATURE OF THE INHIBITORS -- 8.2.1. Avoiding
       Inhibition -- 8.3. TISSUES FROM WHERE THE DNA CAN BE 
       EXTRACTED -- CONCLUDING REMARKS -- CONFLICT OF INTEREST --
       ACKNOWLEDGEMENTS -- REFERENCES -- aDNA Methodological 
       Revolution -- 9.1. EVOLUTION OF THE EXTRACTION METHODS -- 
       9.2. EVOLUTION OF THE SEQUENCING METHODS -- 9.2.1. Next-
       Generation Sequencing -- 9.2.2. Enrichment Techniques -- 
       9.2.3. Passing from Second to Third Generation Sequencing 
       Technologies: Advantages of Single-Stranded Library 
       Preparation -- 9.3. RECONSIDERING AUTHENTICITY CRITERIA --
       CONCLUDING REMARKS AND FUTURE PERSPECTIVES -- CONFLICT OF 
       INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Complicities
       Between Forensic Anthropology and Forensic Genetics: New 
       Opportunities for Genomics? -- 10.1. INTRODUCTION: MAIN 
       ATTRIBUTIONS OF FORENSIC ANTHROPOLOGY -- 10.2. WHEN DOES 
       FORENSIC ANTHROPOLOGY NEEDS GENETICS? -- 10.2.1. To 
       Determine whether the Remains are Human -- 10.2.2. In 
       Crime Scenes and Other Particular Scenarios -- 10.2.3. 
       Performing Sex Diagnosis -- 10.2.4. Performing Ancestry 
       Analysis -- 10.2.5. Identifying Specific Bacteria -- 
       10.2.6. Performing a Positive Identification 
505 8  10.3. AN EMERGENT ROLE FOR GENOMICS IN FORENSIC SCIENCES? 
       -- CONCLUDING REMARKS -- CONFLICT OF INTEREST -- 
       ACKNOWLEDGEMENTS -- REFERENCES -- SUBJECT INDEX 
588    Description based on publisher supplied metadata and other
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590    Electronic reproduction. Ann Arbor, Michigan : ProQuest 
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650  0 Genomics 
655  4 Electronic books 
700 1  Ramos, Amanda 
776 08 |iPrint version:|aLima, Manuela|tAnthropology: Current and
       Future Developments Volume 2|dOak Park : Bentham Science 
       Publishers,c2016|z9781681083865 
830  0 Anthropology: Current and Future Developments 
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