LEADER 00000nam  2200421   4500 
001    AAI3469289 
005    20121003100307.5 
008    121003s2011    ||||||||||||||||| ||eng d 
020    9781124849522 
035    (UMI)AAI3469289 
040    UMI|cUMI 
100 1  Hodge, Neil Eugene 
245 10 Continuum Modeling and Finite Element Analysis of Cell 
       Motility 
300    86 p 
500    Source: Dissertation Abstracts International, Volume: 72-
       11, Section: B, page: 6843 
500    Adviser: Panayiotis Papadopoulos 
502    Thesis (Ph.D.)--University of California, Berkeley, 2011 
520    Cell motility, and in particular crawling, is a complex 
       process, with many as yet unknown details (e.g., sources 
       of viscosity in the cell, precise structure of focal 
       adhesions).  However, various models of the motility of 
       cells are emerging.  These models concentrate on different
       aspects of cellular behavior, from the motion of a single 
       cell itself, to -taxis behaviors, to population models.  
       Models of single cells seem to vary significantly in their
       intended scope and the level of detail included 
520    Most single cells are far too large and complex to be 
       globally amenable to fine-scale modeling.  At the same 
       time, cells are subject to external and internal 
       influences that are connected to their fine-scale 
       structure.  This work presents a continuum model, 
       including the use of a continuum theory of surface growth,
       that will predict the crawling motion of the cell, with 
       consideration made for the appropriate fine-scale 
       dependencies 
520    This research addresses several modeling aspects.  At the 
       continuum level, the relationships between force and 
       displacement in the bulk of the cell are modeled using the
       balance laws developed in continuum mechanics.  Allowances
       are made for the treatment of and interaction between 
       multiple protein species, as well as for the addition of 
       various terms into the balance laws ( e.g., stresses 
       generated by protein interactions).  Various assumptions 
       regarding the nature of cell crawling itself and its 
       modeling are discussed.  For instance, the extension of 
       the lamellipod/detachment of the cell is viewed as a 
       growth/resorption process.  The model is derived without 
       reference to dimensionality 
520    The second component of the presentation concerns the 
       numerical implementation of the cell motility model.  This
       is accomplished using finite elements, with special 
       features (i.e., ALE, discontinuous elements) being used to
       handle certain stages of the motility.  In particular, the
       growth assumption used to model the crawling motility is 
       represented using ALE, while the strong discontinuities 
       that arise out of the growth model are represented using 
       the discontinuous elements.  Results from representative 
       finite element simulations are shown to illustrate the 
       modeling capabilities 
590    School code: 0028 
650  4 Applied Mechanics 
650  4 Applied Mathematics 
650  4 Biology, Cell 
690    0346 
690    0364 
690    0379 
710 2  University of California, Berkeley.|bMechanical 
       Engineering 
773 0  |tDissertation Abstracts International|g72-11B 
856 40 |uhttp://pqdd.sinica.edu.tw/twdaoapp/servlet/
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