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作者 Pusey, Marc L., author
書名 Data analytics for protein crystallization / by Marc L. Pusey, Ramazan Savas Aygun
出版項 Cham : Springer International Publishing : Imprint: Springer, 2017
國際標準書號 9783319589374 (electronic bk.)
9783319589367 (paper)
國際標準號碼 10.1007/978-3-319-58937-4 doi
book jacket
說明 1 online resource (xx, 231 pages) : illustrations, digital ; 24 cm
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
系列 Computational biology, 1568-2684 ; volume 25
Computational biology ; volume 25
附註 Introduction to Protein Crystallization -- Scoring and Phases of Crystallization -- Computational Methods for Protein Crystallization Screening -- Robotic Image Acquisition -- Classification of Crystallization Trial Images -- Crystal Growth Analysis -- Focal Stacking for Crystallization Microscopy -- Crystal Image Region Segmentation -- Visualization -- Other Structure Determination Methods -- Future of Computational Protein Crystallization
This unique text/reference presents an overview of the computational aspects of protein crystallization, describing how to build robotic high-throughput and crystallization analysis systems. The coverage encompasses the complete data analysis cycle, including the set-up of screens by analyzing prior crystallization trials, the classification of crystallization trial images by effective feature extraction, the analysis of crystal growth in time series images, the segmentation of crystal regions in images, the application of focal stacking methods for crystallization images, and the visualization of trials. Topics and features: Describes the fundamentals of protein crystallization, and the scoring and categorization of crystallization image trials Introduces a selection of computational methods for protein crystallization screening, and the hardware and software architecture for a basic high-throughput system Presents an overview of the image features used in protein crystallization classification, and a spatio-temporal analysis of protein crystal growth Examines focal stacking techniques to avoid blurred crystallization images, and different thresholding methods for binarization or segmentation Discusses visualization methods and software for protein crystallization analysis, and reviews alternative methods to X-ray diffraction for obtaining structural information Provides an overview of the current challenges and potential future trends in protein crystallization This interdisciplinary work serves as an essential reference on the computational and data analytics components of protein crystallization for the structural biology community, in addition to computer scientists wishing to enter the field of protein crystallization. Dr. Marc L. Pusey is a Research Scientist at iXpressGenes, Inc. Huntsville, AL, USA. Dr. Ramazan Savas Aygun is an Associate Professor in the Computer Science Department of the University of Alabama in Huntsville, USA
Host Item Springer eBooks
主題 Biology -- Data processing
Crystalloids (Botany)
Computer Science
Computational Biology/Bioinformatics
Data Mining and Knowledge Discovery
Image Processing and Computer Vision
Molecular Medicine
Alt Author Aygun, Ramazan Savas, author
SpringerLink (Online service)
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