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作者 Gasser, Gilles
書名 Inorganic Chemical Biology : Principles, Techniques and Applications
出版項 New York : John Wiley & Sons, Incorporated, 2014
©2014
國際標準書號 9781118684252 (electronic bk.)
9781118510025
book jacket
版本 1st ed
說明 1 online resource (433 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
附註 Cover -- Title Page -- Copyright -- Contents -- About the Editor -- List of Contributors -- Preface -- Acknowledgements -- Chapter 1 New Applications of Immobilized Metal Ion Affinity Chromatography in Chemical Biology -- 1.1 Introduction -- 1.2 Principles and Traditional Use -- 1.3 A Brief History -- 1.4 New Application 1: Non-protein Based Low Molecular Weight Compounds -- 1.4.1 Siderophores -- 1.4.2 Anticancer Agent: Trichostatin A -- 1.4.3 Anticancer Agent: Bleomycin -- 1.4.4 Anti-infective Agents -- 1.4.5 Other Agents -- 1.4.6 Selecting a Viable Target -- 1.5 New Application 2: Multi-dimensional Immobilized Metal Ion Affinity Chromatography -- 1.6 New Application 3: Metabolomics -- 1.7 New Application 4: Coordinate-bond Dependent Solid-phase Organic Synthesis -- 1.8 Green Chemistry Technology -- 1.9 Conclusion -- Acknowledgments -- References -- Chapter 2 Metal Complexes as Tools for Structural Biology -- 2.1 Structural Biological Studies and the Major Techniques Employed -- 2.2 What do Metal Complexes have to Offer the Field of Structural Biology? -- 2.3 Metal Complexes for Phasing in X-ray Crystallography -- 2.4 Metal Complexes for Derivation of Structural Restraints via Paramagnetic NMR Spectroscopy -- 2.4.1 Paramagnetic Relaxation Enhancement (PRE) -- 2.4.2 Residual Dipolar Coupling (RDC) -- 2.4.3 Pseudo-Contact Shifts (PCS) -- 2.4.4 Strategies for Introducing Lanthanide Ions into Bio-Macromolecules -- 2.5 Metal Complexes as Spin Labels for Distance Measurements via EPR Spectroscopy -- 2.6 Metal Complexes as Donors for Distance Measurements via Luminescence Resonance Energy Transfer (LRET) -- 2.7 Concluding Statements and Future Outlook -- References -- Chapter 3 AAS, XRF, and MS Methods in Chemical Biology of Metal Complexes -- 3.1 Introduction -- 3.2 Atomic Absorption Spectroscopy (AAS) -- 3.2.1 Fundamentals and Basic Principles of AAS
3.2.2 Instrumental and Technical Aspects of AAS -- 3.2.3 Method Development and Aspects of Practical Application -- 3.2.4 Selected Application Examples -- 3.3 Total Reflection X-Ray Fluorescence Spectroscopy (TXRF) -- 3.3.1 Fundamentals and Basic Principles of TXRF -- 3.3.2 Instrumental/Methodical Aspects of TXRF and Applications -- 3.4 Subcellular X-ray Fluorescence Imaging of a Ruthenium Analogue of the Malaria Drug Candidate Ferroquine Using Synchrotron Radiation -- 3.4.1 Application of X-ray Fluorescence in Drug Development Using Ferroquine as an Example -- 3.5 Mass Spectrometric Methods in Inorganic Chemical Biology -- 3.5.1 Mass Spectrometry and Inorganic Chemical Biology: Selected Applications -- 3.6 Conclusions -- Acknowledgements -- References -- Chapter 4 Metal Complexes for Cell and Organism Imaging -- 4.1 Introduction -- 4.2 Photophysical Properties -- 4.2.1 Fluorescence and Phosphorescence -- 4.2.2 Two-photon Absorption -- 4.2.3 Upconversion Luminescence -- 4.3 Detection of Luminescent Metal Complexes in an Intracellular Environment -- 4.3.1 Confocal Laser-scanning Microscopy -- 4.3.2 Fluorescence Lifetime Imaging Microscopy -- 4.3.3 Flow Cytometry -- 4.4 Cell and Organism Imaging -- 4.4.1 Factors Affecting Cellular Uptake -- 4.4.2 Organelle Imaging -- 4.4.3 Two-photon and Upconversion Emission Imaging for Cells and Organisms -- 4.4.4 Intracellular Sensing and Labeling -- 4.5 Conclusion -- Acknowledgements -- References -- Chapter 5 Cellular Imaging with Metal Carbonyl Complexes -- 5.1 Introduction -- 5.2 Vibrational Spectroscopy of Metal Carbonyl Complexes -- 5.3 Microscopy and Imaging of Cellular Systems -- 5.3.1 Techniques of Vibrational Microscopy -- 5.4 Infrared Microscopy -- 5.4.1 Concentration Measurements with IR Spectroscopy and Spectromicroscopy -- 5.4.2 Water Absorption
5.4.3 Metal Carbonyls as IR Probes for Cellular Imaging -- 5.4.4 In Vivo Uptake and Reactivity of Metal Carbonyl Complexes -- 5.5 Raman Microscopy -- 5.5.1 Concentration Measurements with Raman Spectroscopy and Spectromicroscopy -- 5.5.2 Metal Carbonyls as Raman Probes for Cellular Imaging -- 5.6 Near-field Techniques -- 5.6.1 Concentration Measurements with Near-field Techniques -- 5.6.2 High-resolution Measurement of Intracellular Metal-Carbonyl Accumulation by Photothermal Induced Resonance -- 5.7 Comparison of Techniques -- 5.8 Conclusions and Outlook -- Acknowledgements -- References -- Chapter 6 Probing DNA Using Metal Complexes -- 6.1 General Introduction -- 6.2 Photophysics of Ru(II) Complexes -- 6.2.1 The First Ru(II) Complex Studied in the Literature: [Ru(bpy)3]2+ -- 6.2.2 Homoleptic Complexes -- 6.2.3 Heteroleptic Complexes -- 6.2.4 Photoinduced Electron Transfer (PET) and Energy Transfer Processes -- 6.3 State-of-the-art on the Interactions of Mononuclear Ru(II) Complexes with Simple Double-stranded DNA -- 6.3.1 Studies on Simple Double-stranded DNAs -- 6.3.2 Influence of DNA on the Emission Properties -- 6.4 Structural Diversity of the Genetic Material -- 6.4.1 Mechanical Properties of DNA -- 6.4.2 DNA Topology -- 6.4.3 SMF Study with [Ru(phen)2(PHEHAT)]2+ and [Ru(TAP)2(PHEHAT)]2+ -- 6.5 Unusual Interaction of Dinuclear Ru(II) Complexes with Different DNA Types -- 6.5.1 Reversible Interaction of [{(Ru(phen)2}2HAT]4+ with Denatured DNA -- 6.5.2 Targeting G-quadruplexes with Photoreactive [{Ru(TAP)2}2TPAC]4+ -- 6.5.3 Threading Intercalation -- 6.6 Conclusions -- Acknowledgement -- References -- Chapter 7 Visualization of Proteins and Cells Using Dithiol-reactive Metal Complexes -- 7.1 The Chemistry of As(III) and Sb(III) -- 7.2 Cysteine Dithiols in Protein Function -- 7.3 Visualization of Dithiols in Isolated Proteins with As(III)
7.4 Visualization of Dithiols on the Mammalian Cell Surface with As(III) -- 7.5 Visualization of Dithiols in Intracellular Proteins with As(III) -- 7.6 Visualization of Tetracysteine-tagged Recombinant Proteins in Cells with As(III) -- 7.7 Visualization of Cell Death in the Mouse with Optically Labelled As(III) -- 7.7.1 Cell Death in Health and Disease -- 7.7.2 Cell Death Imaging Agents -- 7.7.3 Visualization of Cell Death in Mouse Tumours, Brain and Thrombi with Optically Labelled As(III) -- 7.8 Visualization of Cell Death in Mouse Tumours with Radio-labelled As(III) -- 7.9 Summary and Perspectives -- References -- Chapter 8 Detection of Metal Ions, Anions and Small Molecules Using Metal Complexes -- 8.1 How Do We See What's in a Cell? -- 8.1.1 Why Metal Complexes as Sensors? -- 8.1.2 Design Strategies for Sensors Built with Metal Complexes -- 8.1.3 General Criteria of Metal-based Sensors for Bioimaging -- 8.2 Metal Complexes for Detection of Metal Ions -- 8.2.1 Tethered Sensors for Detecting Metal Ions -- 8.2.2 Displacement Sensors for Detecting Metal Ions -- 8.2.3 MRI Contrast Agents for Detecting Metal Ions -- 8.2.4 Chemodosimeters for Metal Ions -- 8.3 Metal Complexes for Detection of Anions and Neutral Molecules -- 8.3.1 Tethered Approach: Metal Complex as Recognition Unit -- 8.3.2 Displacement Approach: Metal Complex as Quencher -- 8.3.3 Dosimeter Approach -- 8.4 Conclusions -- Acknowledgements -- Abbreviations -- References -- Chapter 9 Photo-release of Metal Ions in Living Cells -- 9.1 Introduction to Photochemical Tools Including Photocaged Complexes -- 9.2 Calcium Biochemistry and Photocaged Complexes -- 9.2.1 Strategies for Designing Photocaged Complexes for Ca2+ -- 9.2.2 Biological Applications of Photocaged Ca2+ Complexes -- 9.3 Zinc Biochemistry and Photocaged Complexes -- 9.3.1 Biochemical Targets for Photocaged Zn2+ Complexes
9.3.2 Strategies for Designing Photocaged Complexes for Zn2+ -- 9.4 Photocaged Complexes for Other Metal Ions -- 9.4.1 Photocaged Complexes for Copper -- 9.4.2 Photocaged Complexes for Iron -- 9.4.3 Photocaged Complexes for Other Metal Ions -- 9.5 Conclusions -- Acknowledgment -- References -- Chapter 10 Release of Bioactive Molecules Using Metal Complexes -- 10.1 Introduction -- 10.2 Small-molecule Messengers -- 10.2.1 Biological Generation and Delivery of CO, NO, and H_2S -- 10.2.2 Metal-Nitrosyl Complexes for the Cellular Delivery of Nitric Oxide -- 10.2.3 CO-releasing Molecules (CORMs) -- 10.3 "Photouncaging'' of Neurotransmitters from Metal Complexes -- 10.3.1 "Caged'' Compounds -- 10.3.2 "Uncaging'' of Bioactive Molecules -- 10.4 Hypoxia Activated Cobalt Complexes -- 10.4.1 Bioreductive Activation of Cobalt Complexes -- 10.4.2 Hypoxia-activated Cobalt Prodrugs of DNA Alkylators -- 10.4.3 Hypoxia-activated Cobalt Prodrugs of MMP Inhibitors -- 10.5 Summary -- Acknowledgments -- References -- Chapter 11 Metal Complexes as Enzyme Inhibitors and Catalysts in Living Cells -- 11.1 Introduction -- 11.2 Metal-based Inhibitors: From Serendipity to Rational Design -- 11.2.1 Mimicking the Structure of Known Enzyme Binders -- 11.2.2 Coordinating Known Enzymatic Inhibitors to Metal Complexes -- 11.2.3 Exchanging Ligands to Inhibit Enzymes -- 11.2.4 Controlling Conformation by Metal Coordination -- 11.2.5 Competing with Known Metallo-Enzymatic Processes -- 11.3 The Next Generation: Polynuclear Metal Complexes as Enzyme Inhibitors -- 11.3.1 Polyoxometalates: Broad Spectrum Enzymatic Inhibitory Effects -- 11.3.2 Polynuclear G-quadruplex DNA Stabilizers: Potential Inhibitors of Telomerase -- 11.3.3 Polynuclear Polypyridyl Ruthenium Complexes: DNA Topoisomerase II Inhibitors -- 11.4 Metal Complexes as Catalysts in Living Cells -- 11.4.1 Catalysis of NAD+/NADH
11.4.2 Oxidation of the Thiols Cysteine and Glutathione
EditorGilles Gasser, Department of Chemistry, University of Zurich, Switzerland
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Gasser, Gilles Inorganic Chemical Biology : Principles, Techniques and Applications New York : John Wiley & Sons, Incorporated,c2014 9781118510025
主題 Metals - chemistry
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