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作者 Samkoff, Lawrence M
書名 Multiple Sclerosis and CNS Inflammatory Disorders
出版項 Hoboken : John Wiley & Sons, Incorporated, 2014
©2014
國際標準書號 9781118298664 (electronic bk.)
9780470673881
book jacket
版本 1st ed
說明 1 online resource (214 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 NIP- Neurology in Practice Ser
NIP- Neurology in Practice Ser
附註 Intro -- Multiple Sclerosis and CNS Inflammatory Disorders -- Copyright -- Contents -- Contributors -- Series Foreword -- Preface -- 1 Etiology -- Background -- Genes -- Gender effects: Genetic or biologic? -- The role of the environment -- Environmental MS risk factors: The major players -- Vitamin D -- Infection -- Smoking -- Combining risk factors -- Conclusion -- Acknowledgment -- References -- 2 Immunopathogenesis of Multiple Sclerosis -- What does the neuropathology of MS tell us about its pathogenesis? -- Gray matter pathology -- Multiple sclerosis as an autoimmune disease -- Candidates for the self-antigen in multiple sclerosis -- Antigen spreading -- Epitope spreading -- Outside-in versus inside-out ? -- Lymphocyte trafficking into the CNS -- Role of T cells in MS -- Role of B cells and humoral immunity -- Role of microglia and macrophages -- Role of other cells: Dendritic cells and astrocytes -- Role of cytokines -- What might trigger autoimmunity? -- Further Reading -- 3 Diagnostic Process -- Introduction -- Clinical features of MS -- Defining MS -- MS disease courses -- Common symptoms in MS -- Diagnostic evaluation of MS -- MRI -- Revised McDonald criteria for diagnosis of  MS -- Ancillary testing in the diagnosis of MS -- Differential diagnosis of MS -- Conclusion -- Further Reading -- 4 MRI in Diagnosis and Disease Monitoring -- Introduction -- MRI at presentation -- Lesions -- Brain atrophy -- Spinal cord -- MRI diagnostic criteria -- MRI consensus protocol -- MRI for monitoring disease and treatment -- New lesion activity -- Brain atrophy -- Limitations -- Nonconventional MRI -- Magnetization transfer imaging -- Magnetic resonance spectroscopy -- Susceptibility-weighted imaging -- Diffusion-weighted imaging -- Perfusion-weighted imaging -- Conclusions -- Acknowledgments -- References
5 Relapsing MS: Disease Staging and Therapeutic Algorithms -- Introduction -- Window -- Prognostic factors -- Therapy -- Initiation -- Early window -- Late window -- Suboptimal response -- Intolerance: Lateral therapy -- Mild breakthrough: Lateral therapy -- Major breakthrough -- Combination therapy -- Rescue therapy -- Escalation -- Rapid advancement -- Conclusion -- Newer oral agents -- Further Reading -- 6 Progressive MS Treatment Algorithms -- Background -- Challenges to clinical trials in progressive MS -- Clinical trials in progressive MS -- Interferon-beta -- Glatiramer acetate -- Mitoxantrone -- Cyclophosphamide -- Methotrexate -- Methylprednisolone -- Other disease-modifying therapies -- Monitoring progressive MS in clinical practice -- Treatment of progressive MS in clinical practice -- Stopping disease-modifying therapy -- Neuroprotective strategies -- Other treatment considerations -- Further Reading -- 7 Sex-Determined Issues in Multiple Sclerosis -- Epidemiology of MS and gender -- Basic science of sex hormone and chromosome differences seen in MS -- Actions of sex hormones -- Gender effects seen in genetics of MS -- Reproductive issues in MS -- Menstrual cycle and menopause -- Effects on fertility -- Contraceptive issues -- Congenital effects -- Pregnancy and the MS patient -- Epidemiology -- Clinical concerns -- Management of pregnant patient: Before, during, and after -- Breastfeeding -- Female cancers -- Male sex hormones and concerns for the male patient -- Acknowledgments -- References -- 8 Pediatric Multiple Sclerosis -- Introduction -- Definitions -- ADEM, and multiphasic  ADEM -- Clinically isolated syndromes (CIS) -- Pediatric multiple sclerosis -- Clinical outcome following a first demyelinating attack -- Epidemiology and risk factors -- Clinical presentation -- Disease course -- Diagnostic considerations -- MRI
Spinal fluid -- Evoked potentials -- Differential diagnosis -- Treatment of acute demyelinating attacks -- Disease-modifying therapy -- Interferon-beta -- Glatiramer acetate -- Escalation of care for severe MS -- Natalizumab -- Other agents -- Symptomatic therapy -- Cognitive dysfunction and quality of life considerations -- Conclusions and future directions -- Further Reading -- 9 Complementary and Alternative Medicine: Risks and Benefits -- Introduction -- Terminology -- Unconventional medicine use -- CAM therapies -- Antioxidants -- Bee venom therapy -- Cooling therapy -- Cranberry -- Diets: The Swank diet and related diets -- Echinacea and other immune-stimulating supplements -- Ginkgo biloba -- Guided imagery -- Low-dose naltrexone (LDN) -- Marijuana (cannabis) -- Massage -- Reflexology -- Tai chi -- Vitamin B12 -- Vitamin D -- Yoga -- Conclusion -- Further Reading -- 10 Symptomatic Management of MS -- Bladder dysfunction -- Bowel dysfunction -- Sexual dysfunction -- Pain -- Paroxysmal pain -- Constant pain -- Impaired gait -- Spasticity -- Tremor -- Further Reading -- 11 Invisible Symptoms of MS: Fatigue, Depression, and Cognition -- Introduction -- Fatigue -- Assessment -- Pathogenesis -- Management -- Cognition -- Assessment -- Pathogenesis -- Treatment -- Depression -- Assessment -- Pathogenesis -- Treatment -- Summary -- Reference -- Further Reading -- 12 Rehabilitation -- Introduction -- Physical rehabilitation -- Ambulation: Principles and perturbations -- Improving ambulation -- Upper extremity function -- Home modifications -- Organ rehabilitation: Bladder and bowel management -- Cognitive rehabilitation -- Challenges in diagnosis -- The case for nonpharmacological treatment -- Summary -- References -- 13 Psychosocial Adaptation to Multiple Sclerosis -- Introduction -- Coping and adaptation -- Stages and phases in the adaptation process
Prediagnosis phases -- The crisis phase -- The interim/transitional phase -- Chronic phase -- The accommodation phase -- Acknowledgments -- References -- 14 Transverse Myelitis and Acute Disseminated Encephalomyelitis -- Introduction -- Transverse myelitis -- Epidemiology -- Pathobiology -- Clinical presentation -- Differential diagnosis and diagnostic criteria -- Acute treatment -- Outcomes and long-term management -- Acute disseminated encephalomyelitis (ADEM) -- Epidemiology -- Pathobiology -- Clinical presentation -- Differential diagnosis and diagnostic criteria -- Acute treatment -- Outcomes and long-term management -- References -- 15 Neuromyelitis Optica -- Introduction -- Diagnosis -- Demographic features -- Clinical characteristics -- Diagnostic criteria -- Investigations -- Differential diagnosis -- Treatment -- Acute treatment -- Long-term treatment -- Future treatment perspectives -- Prognosis and follow-up -- Measuring disability -- Antibody serology and titers -- 16 Neurosarcoidosis -- Introduction -- General principles of diagnosis -- General principles of treatment -- Dosages -- Specific presentations -- Aseptic meningitis -- Myelopathy -- Cerebral neurosarcoidosis -- Cranial neuropathy -- Peripheral neuropathy and myopathy -- Prognosis and long-term monitoring -- Further Reading -- 17 Lyme Neuroborreliosis -- Introduction -- Borrelia burgdorferi infection -- Nonneurologic manifestations -- Early neurologic manifestations -- Later-onset neurologic manifestations -- Diagnosis -- Differential diagnosis -- Treatment -- Conclusion -- Acknowledgments -- References -- Further Reading -- 18 Neuro-Behçet Syndrome -- Introduction -- Epidemiology -- Diagnosis and systemic manifestations of Behçet disease -- Oral aphthae -- Genital ulceration -- Skin lesions -- Eye involvement -- The pathergy phenomenon -- Musculoskeletal involvement
Gastrointestinal involvement -- Cardiovascular involvement -- Other systems -- Laboratory investigations -- Pathology and etiopathogenesis of Behçet syndrome -- Nervous system involvement in Behçet disease: Neuro-Behçet syndrome -- Extra-axial NBS -- Intra-axial NBS -- Arterial NBS -- Neuro-psycho-Behçet syndrome -- Cognitive changes in BD -- Headache in BS -- PNS involvement -- Subclinical NBS -- Diagnostic studies in NBS -- Neuroimaging -- CSF -- Differential diagnosis -- Prognosis -- Treatment -- Intra-axial NBS -- Extra-axial NBS -- References -- Index
Multiple Sclerosis and CNS Inflammatory Disorders is a practical guide to effective care of patients with multiple sclerosis and other neuroimmunologic and CNS inflammatory disorders. It provides the scientific basis of multiple sclerosis including etiology, epidemiology, and pathogenesis. It covers the diagnostic process, the course of the disease and prognosis, and the use of MRI in diagnosis and disease monitoring. Disease-modifying  treatment algorithms for relapsing-remitting multiple sclerosis, switching therapy, and progressive multiple sclerosis treatment algorithms are all discussed in detail. It also addresses multiple sclerosis in childhood and pregnancy and includes assessment of alternative therapies. This new addition to the Neurology in Practice series contains practical guidance and learning features: Algorithms and guidelines "Tips and Tricks" boxes on improving outcomes "Caution" warning boxes to avoiding problems "Science Revisited"-quick reminders of the basic science principles necessary for understanding Multiple Sclerosis and CNS Inflammatory Disorders is an ideal reference for neurologists in practice and training
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Samkoff, Lawrence M. Multiple Sclerosis and CNS Inflammatory Disorders Hoboken : John Wiley & Sons, Incorporated,c2014 9780470673881
主題 Neurogenic Inflammation - physiopathology
Electronic books
Alt Author Goodman, Andrew D
Goodman, Andrew D
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