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作者 Wilson, Michael P
書名 Doing Research in Emergency and Acute Care : Making Order Out of Chaos
出版項 New York : John Wiley & Sons, Incorporated, 2015
©2015
國際標準書號 9781118643471 (electronic bk.)
9781118643440
book jacket
版本 1st ed
說明 1 online resource (452 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
附註 Intro -- Title page -- Table of Contents -- List of contributors -- PART 1: Getting ready: Preparing for your research study -- CHAPTER 1: Aspects of research specific to acute care -- Responsibility of the academic physician -- Asking the right questions -- Challenges with acute care research -- Where do I start? -- Roadblocks, errors, and things to avoid -- CHAPTER 2: Aspects of feasibility in research -- Safety considerations -- Expertise and infrastructure -- Compliance with study procedures -- "Recruitability" -- Sustainability considerations -- References -- CHAPTER 3: How do I formulate a research question? -- Characteristics of an interesting question -- Making a question interesting -- Time and resources to answer a question -- Translating a question into a hypothesis -- Ethical concerns -- References -- CHAPTER 4: Evidence-based medicine: Finding the knowledge gap -- Evidence synthesis/systematic reviews -- Structured critical appraisal -- Knowledge translation -- Conclusion -- References -- CHAPTER 5: How to carry out an efficient literature search -- Part I: Surveying the research landscape -- Part II: The deep dive -- Summary -- References -- CHAPTER 6: What do I need to know to get started with animal and basic science research? -- Laboratory space -- Equipment and supplies -- Choosing the right model -- Laboratory workers -- Mentors and collaborators -- Funding -- "So you want to do a single preclinical study?" An approach for the ad hoc investigator -- References -- CHAPTER 7: The IRB process: How to write up a human studies protocol -- Introduction -- Key issues -- Conclusion -- References -- CHAPTER 8: Ethics in research: How to collect data ethically -- The philosophical foundation of experimental research -- Historical case studies that have shaped how human research is conducted -- The establishment of the Belmont Principles
The ethical standards to which we are held today -- The Institutional Review Board -- Summary -- References -- CHAPTER 9: Safety in research: How to ensure patient safety? -- How do we protect patients in our studies? -- Adverse events -- FDA reporting requirements -- Data safety monitoring plans and data safety monitoring boards -- Clinical trial monitors, contract research organizations, and clinical research associates -- References -- Further reading -- PART 2: Getting it done: Doing your research study -- CHAPTER 10: How to design a study that everyone will believe: Minimizing bias and confounding -- Bias -- Confounding -- References -- CHAPTER 11: How to design a study that everyone will believe: An overview of research studies and picking the right design -- Introduction -- Overview of study designs -- Randomized controlled trials -- Cohort studies -- Case-control studies -- Cross-sectional studies -- Case series -- Meta-analyses -- Conclusion -- References -- CHAPTER 12: How to design a study that everyone will believe: Random selection and allocation of patients to treatment conditions -- Why conduct a randomized control trial? -- Planning a clinical trial -- The planning phase -- The preparatory phase -- Recruitment phase -- The patient follow-up and termination phase -- The analysis phase -- Ethical aspects of research -- References -- CHAPTER 13: How to design a study that everyone will believe: Surveys -- Overview of survey methodology -- Administration -- Survey methods -- Technology and surveys -- Time to develop your survey -- Survey questions -- Survey layout and respondent interaction -- Final steps -- Further reading -- CHAPTER 14: How to design a study that everyone will believe: Retrospective reviews -- Why are retrospective reviews held in a negative light? -- With the existing bias against chart reviews, why spend the time?
What are the limitations to retrospective review? -- Designing a believable retrospective study -- References -- CHAPTER 15: How to design a study that everyone will believe: Prehospital studies -- External validity -- Sample size (Power) -- Methodology -- Informed consent -- Patient outcomes -- Relevance -- A few parting thoughts -- References -- CHAPTER 16: How to design a study that everyone will believe: Ethical concepts for special populations in emergency research -- Introduction -- Primer on ethics -- Application of concepts -- Conclusion -- References -- CHAPTER 17: How to design a study that everyone will believe: Industry studies -- Introduction -- Coming up with a question -- Types of industry studies or clinical trials -- Developing methods -- Getting started with industry-sponsored research funding -- Data safety monitoring boards -- Material safety transfer agreements -- Compensation -- Publication -- Pitfalls -- Conflicts of interest -- IRB issues -- Recruiting patients -- Summary -- References -- CHAPTER 18: How to design a study that everyone will believe: Prospective studies -- Introduction -- Observational studies -- Cohort studies -- Randomized control study designs with a placebo group -- Randomized clinical trials without a placebo group -- Epilogue -- Summary -- References -- CHAPTER 19: How to design a study that everyone will believe: Effectiveness, safety, and the intention to treat -- Real world issues that occur in clinical research -- Which came first: The efficacy or the effectiveness study and what is the difference anyway? -- So your patient is a no-show for the rest of the study. Now what? Intention-to-Treat Analysis -- The good the bad and the ugly: Pros and cons of intention-to-treat analysis -- Filling in the blanks: Types of missing data and techniques for replacing missing data points -- Summary -- References
CHAPTER 20: How to design a study that everyone will believe: Emergency department operations and systems -- Studying operations and flow in an acute care setting -- Benchmarking -- Informatics -- Improving operations-based research -- Conclusion -- References -- CHAPTER 21: How to design a study that everyone will believe: The challenges of doing international research -- Quality work -- "Inter-nation-al" means between and among nations -- Ethics -- Be respectful -- Applicability -- Readers? What readers? -- Summary -- References -- CHAPTER 22: The development of clinical prediction rules -- What is a clinical decision instrument? -- Choosing a CDI focus -- Developing a CDI: Research methods -- Advanced topics -- References -- CHAPTER 23: Testing the safety and efficacy of devices: Device safety, as well as obtaining an IDE (investigational device exemption) from the FDA -- Step one: Protect your invention -- Step two: Innovate -- Step three -- Step four -- Step five: Obtain reimbursement for your device -- Obtaining an IDE (Investigational Device Exemption) from the FDA -- Summary -- References -- CHAPTER 24: Privacy in research: How to collect data safely and confidentially -- Overview -- What is HIPPA? -- Informed consent and impact on privacy -- Protected health information and anonymity -- Protecting and storing the data -- Futher reading -- CHAPTER 25: How do I establish a research assistant program? -- What is an research assistant program and why do I need one? -- Why do you need an academic associate program? -- What does an academic associate program cost my department? -- What do other research faculty get out of it? -- What do research faculty have to do in return for use of the academic associates? -- What do non-research faculty get out of it? -- Sounds great. How do I establish an academic associates program?
How many students do you take? -- What exactly is the curriculum? -- Are you really crazy enough to have classes and examinations for volunteers? -- How do students sign up, get trained and supervised? -- Once created, where do you find students? -- How many clinical studies can you conduct at the same time? -- Can the academic associates do more than just collect data in the ED? -- What do the students get out of it? -- References -- CHAPTER 26: How to complete a research study well and in a minimum of time: The importance of collaboration -- Working with your team -- The collaborator standing next to you -- The collaborator down the hall -- Dirty jobs: Assigning authorship -- References -- PART 3: Getting it out there: Analyzing and publishing your study -- CHAPTER 27: Eliminating common misconceptions to enable intelligent use of biostatistics: How can a novice use statistics more intelligently? -- Recognizing types of data [1] -- Describing data [6] -- Statistical inference, random sampling, bias and error [1] -- Matching the type of data to the appropriate inferential statistical test [8, 9] -- Summary -- References -- CHAPTER 28: Basic statistics: sample size and power: How are sample size and power calculated? -- The purpose of sample size and power calculations -- Important definitions relevant to sample size and power calculations -- What is power? -- Factors influencing sample size and power -- When should you perform a sample size calculation? -- How do you perform a sample size and power calculation when testing for a possible difference between groups? -- How do you perform a sample size and power calculation when undertaking an equivalence or non-inferiority trial? -- Summary -- References -- CHAPTER 29: Basic statistics: Means, P values, and confidence intervals -- Outlining your study -- Describing your sample -- Comparing groups
Accounting for chance
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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Wilson, Michael P. Doing Research in Emergency and Acute Care : Making Order Out of Chaos New York : John Wiley & Sons, Incorporated,c2015 9781118643440
主題 Biomedical Research - methods
Electronic books
Alt Author Guluma, Kama Z
Hayden, Stephen R
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