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作者 Hoge, Garrett Stewart, II
書名 (4+2) cycloisomerization reactions: Achiral and asymmetric catalysis using Rh(I) bisphosphine complexes
國際標準書號 9780599027077
book jacket
說明 187 p
附註 Source: Dissertation Abstracts International, Volume: 59-09, Section: B, page: 4812
Chair: Scott R. Gilbertson
Thesis (Ph.D.)--Washington University in St. Louis, 1998
We have developed simple and efficient methodology for catalytic intramolecular (4 + 2) cycloisomerizations (equivalent to the Diels-Alder reaction) of unactivated dienes and dienophiles. A cationic rhodium complex modified with the bisphosphine, diphenylphosphinoethane (DIPHOS), was found to be a catalyst for this transformation at room temperature in methylene chloride. Our success with the achiral DIPHOS ligand has led us to explore an asymmetric variant of the reaction using commercially available chiral bisphosphine ligands substituted for DIPHOS. Initial studies have shown that these reactions can generate high enantiomeric excesses. The development and results of both achiral and asymmetric (4 + 2) cycloisomerizations are presented
School code: 0252
DDC
Host Item Dissertation Abstracts International 59-09B
主題 Chemistry, Organic
0490
Alt Author Washington University in St. Louis
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