| 說明 |
187 p |
| 附註 |
Source: Dissertation Abstracts International, Volume: 59-09, Section: B, page: 4812 |
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Chair: Scott R. Gilbertson |
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Thesis (Ph.D.)--Washington University in St. Louis, 1998 |
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We have developed simple and efficient methodology for catalytic intramolecular (4 + 2) cycloisomerizations (equivalent to the Diels-Alder reaction) of unactivated dienes and dienophiles. A cationic rhodium complex modified with the bisphosphine, diphenylphosphinoethane (DIPHOS), was found to be a catalyst for this transformation at room temperature in methylene chloride. Our success with the achiral DIPHOS ligand has led us to explore an asymmetric variant of the reaction using commercially available chiral bisphosphine ligands substituted for DIPHOS. Initial studies have shown that these reactions can generate high enantiomeric excesses. The development and results of both achiral and asymmetric (4 + 2) cycloisomerizations are presented |
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School code: 0252 |
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DDC |
| Host Item |
Dissertation Abstracts International 59-09B
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| 主題 |
Chemistry, Organic
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0490
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| Alt Author |
Washington University in St. Louis
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