Record:   Prev Next
作者 Scholz, Erwin
書名 Multiple Sclerosis : Causes, Diagnosis and Management
出版項 Hauppauge : Nova Science Publishers, Incorporated, 2011
©2012
國際標準書號 9781614700289 (electronic bk.)
9781613248485
book jacket
說明 1 online resource (168 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 Immunology and Immune System Disorders
Immunology and Immune System Disorders
附註 Intro -- MULTIPLE SCLEROSIS -- MULTIPLE SCLEROSIS -- Contents -- Preface -- B Cells and Autoantibodies in Multiple Sclerosis -- Abstract -- 1. The B Cell Repertoire in Healthy Individuals and MS Patients -- 1.1. B Cell Maturation -- 1.2. B Cell Repertoire in Healthy Individuals and MS Patients -- 2. Functions of B cells in MS Pathogenesis -- 2.1. Antibody Dependent Functions -- 2.2. Antibody Independent Functions -- 3. B Cell Migration and Survival in the CNS -- 4. Evidence for a Role of B Cells and Autoantibodies in MS Pathogenesis -- 5. Analysis of the Humoral Reactivity Profile in MS -- 5.1. Autoantibody Profiling in MS -- 5.1.1. Multiplexing Approaches for Autoantibody Profiling in MS -- 5.1.2. Autoantibody Profiling with Phage Display Technology -- 5.2. B Cell Reactivity Analysis in MS -- 5.2.1. B Cell Immortalization -- 5.2.2. Application of B Cell Immortalization in MS Reactivity Profiling -- 6. Conclusion -- 7. References -- Multiple Sclerosis: The Role of Fatty Acids -- Abstract -- 1.1. Introduction -- 1.2. Epidemiology of Multiple Sclerosis -- 1.3. Types of Multiple Sclerosis -- 1.4. Symptoms -- 1.5. Diagnosis -- 1.5.1. Kurtzke Expanded Disability Status Scale -- 1.6. Treatment -- 1.7. The Aetiology of Multiple Sclerosis -- 1.7.1. Inflammation -- 1.7.1.1. Markers of Inflammation -- 1.7.2. Infectious Agents in Multiple Sclerosis -- 1.7.2.1. Exogenous Viruses -- 1.7.2.2. Endogenous Viruses -- 1.7.2.2. Endogenous Viruses -- 1.8. Metabolic Disturbances in Multiple Sclerosis -- 1.8.1. Cell Membrane Lipids -- 1.8.1.1. Cell Membrane Phospholipids -- 1.8.1.2. Saturated Fatty Acids -- 1.8.1.3. Unsaturated Fatty Acids -- 1.8.1.3.1. Function of Unsaturated Fatty Acids -- 1.8.1.3.2. Unsaturated Fatty Acids in Brain Tissue -- 1.8.1.3.3. Unsaturated Fatty Acids in Biological Fluids -- 1.8.1.4. Cell Membrane Cholesterol
1.8.2. Cell Membrane Fluidity -- 1.8.2.1 Measurement of Cell Membrane Fluidity -- 1.8.3 Lipids as Mediators of Inflammation -- Conclusion -- References -- Multiple Sclerosis: Causes, Diagnosis and Management -- Abstract -- Introduction -- Etiology -- Immunopathophysiology -- Phase 1: Initial Phase, Systemic Infections -- Phase 2: Invasion of Activated Encephalitogenic Immune Effectors into the CNS -- Phase 3: Inflammation - Demyelination -- Diagnosis -- I. Clinical Classification -- II. Confirmation of the Diagnosis Based on Definite Criteria -- IIa. Clinical Criteria -- IIb. Paraclinical Diagnostic Tools -- IIb1. Neuroimaging -- IIb2. CSF -- IIb3. EPs -- III. Differential Diagnosis -- Natural History of MS -- Management -- Modification of the Course of the Disease -- Symptomatic Medications -- Rehabilitation Programs -- References -- Epstein-Barr Virus and Multiple Sclerosis -- Abstract -- Introduction -- The Development of a Hypothesis from 1970 to 2000 -- Association between EBV and MS in Epidemiological Studies -- EBV Strains in MS Patients -- EBV Replication Control and Reactivation in MS Patients -- EBV Humoral Responses in MS Patients -- EBV T Cell Responses in MS Patients -- EBV Infection in the MS Brain -- EBV Infection of Cell Types other than B Cells -- Conclusion -- References -- Actual Relation between Multiple Sclerosis and Epstein-Barr Virus -- Abstract -- Possible Relationship between Infection by Epstein-Barr Virus (EBV) and Multiple Sclerosis (MS) -- Molecular Mimicry Hypothesis -- EBV-infected Autoimmune B-cells Hypothesis -- Superantigen Hypothesis -- Hygiene Hypothesis -- Statistical Analysis of Experimental Studies Showing Association between EBV Infection and MS -- Relationship between the Detection of Antibodies, Individual Genetic Factors and Multiple Sclerosis -- Conclusions -- References
MR Diffusion Tensor Imaging in Multiple Sclerosis: A Regional and Statistical Analysis of Microstructural Alterations -- Abstract -- Introduction -- Conventional MRI -- Diffusion Tensor Imaging -- DTI in Multiple Sclerosis -- Materials and Methods -- Subjects -- MRI Protocol -- Data Analysis and Post-Processing -- Lesion Load Measurement -- Region of Interest Approach -- TBSS Analysis -- Statistical Analysis -- Results -- ROI Measures -- Correlation with T2-LL and EDSS -- TBSS Analysis -- Discussion -- Conclusion -- Acknowledgments -- References -- Immunoglobulin Free Light Chains in the Diagnosis of Multiple Sclerosis -- Abstract -- Introduction -- FLCs in Health and Disease -- Intrathecal Production of FLCs and their Role in MS -- Analysis of Intrathecal and FLCs in MS -- Analysis of Monomeric and Dimeric FLCs in MS -- Conclusions -- References -- Index
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Scholz, Erwin Multiple Sclerosis: Causes, Diagnosis and Management Hauppauge : Nova Science Publishers, Incorporated,c2011 9781613248485
主題 Multiple sclerosis
Electronic books
Alt Author Müller, Carl
Record:   Prev Next