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作者 Hosmane, Narayan S
書名 Boron And Gadolinium Neutron Capture Therapy For Cancer Treatment
出版項 Singapore : World Scientific Publishing Company, 2011
©2012
國際標準書號 9789814338684 (electronic bk.)
9789814338677
book jacket
說明 1 online resource (271 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
附註 Intro -- Contents -- Foreword -- Preface -- About the Authors -- Chapter 1 Introduction -- Chapter 2 What Is Cancer? -- 2.1. Historical Background -- 2.2. Characteristics of Tumors -- 2.3. Origin of Cancer -- 2.4. Environmental Agents -- 2.4.1. Radiation -- 2.4.2. Chemical carcinogens -- 2.4.3. Oncogenic viruses -- 2.4.4. Heredity -- 2.5. Pathology -- 2.6. Grading -- 2.7. Staging -- 2.8. Surgery -- 2.8.1. Various forms of cancer surgery -- 2.8.1.1. Laparoscopic surgery -- 2.8.1.2. Robotic surgery -- 2.8.1.3. Radiofrequency ablation (RFA) -- 2.9. Radiation Therapy -- 2.9.1. Types of radiation therapy -- 2.9.1.1. Brachytherapy -- 2.9.1.2. Conformal radiotherapy -- 2.9.1.3. Stereotactic radiosurgery -- 2.9.1.4. Proton beam therapy -- 2.9.1.5. Neutron capture therapy -- 2.10. Chemotherapy -- 2.10.1. Common chemotherapeutic agents -- 2.10.1.1. Alkylating agents -- 2.10.1.2. Antimetabolites -- 2.10.1.3. Mitotic inhibitors -- 2.10.1.4. Topoisomerase inhibitors -- 2.10.1.5. Anthracyclines -- 2.11. Hematopoietic Stem Cell Transplantation -- 2.12. Hormonal Therapy -- 2.13. Biological Therapies -- 2.13.1. Types of biological therapies -- 2.13.1.1. Monoclonal antibodies -- 2.13.1.2. Angiogenesis inhibitors -- 2.13.1.3. Tyrosine kinase inhibitors -- 2.13.1.4. Proteasome inhibitors -- 2.13.1.5 mTOR inhibitors -- 2.13.1.6. Immunotherapy -- 2.14. Clinical Trials -- 2.15. Long-Term Survival -- 2.16. Prevention -- Chapter 3 Principles of Neutron Capture Therapy -- 3.1. Boron Neutron Capture Therapy (BNCT) -- 3.2. Gadolinium Neutron Capture Therapy (GdNCT) -- Chapter 4 Major Neutron Capture Therapy (NCT) Drug Prototypes -- 4.1. BNCT Agents: Background and General Requirements -- 4.1.1. Blood brain barrier (BBB) -- 4.1.2. Drug delivery methods -- 4.2. Boron Compounds-Based BNCT Agents -- 4.2.1. Clinically used boron compounds
4.2.2. Boronated polyamines as BNCT agents -- 4.2.3. Boronated amino acids and peptides as BNCT agents -- 4.2.4. Boronated nucleic acids as BNCT agents -- 4.2.5. Boronated carbohydrates as BNCT agents -- 4.2.6. Phosphorus-containing boron compounds as BNCT agents -- 4.2.7. Other boron-containing compounds as BNCT agents -- 4.3. Boron-Containing Nanomaterial-Based BNCT Agents -- 4.3.1. Liposomes -- 4.3.2. Dendrimers and dendritic polymers as BNCT agents -- 4.3.3. Boronated carbon nanotubes as BNCT agents -- 4.3.4. Boron nanotubes as BNCT agents -- 4.3.5. Boronated magnetic nanoparticles as BNCT agents -- 4.4. Major Gadolinium Neutron Capture Therapy Drug Types -- 4.4.1. GdNCT agents -- 4.5. Combined Gadolinium and Boron Neutron Capture Therapy (GdBNCT) Agents -- Chapter 5 Neutron Sources for NCT -- 5.1. Introduction -- 5.2. Fission-Based Reactors -- 5.3. Accelerator-Based Neutron Sources -- 5.4. Other Neutron Sources -- 5.4.1. Fusion-based neutron generators -- 5.4.2. Spallation-based systems -- 5.4.3. Isotope decay processes -- Chapter 6 NCT Dosimetry and Treatment Planning -- 6.1. BNCT Dosimetry -- 6.2. GdNCT Dosimetry -- Chapter 7 Selected in vitro and in vivo Studies -- 7.1. In vivo and in vitro Studies Involving BNCT -- 7.2 In vivo and in vitro Studies Involving GdNCT -- 7.2.1 In vitro studies involving GdNCT -- 7.2.2. In vivo studies involving GdNCT -- 7.3. In vitro and in vivo Studies Involving Combined BNCT and GdNCT -- Chapter 8 Clinical Trials -- 8.1. Clinical Trials Using Boron Neutron Capture Therapy (BNCT) -- 8.1.1. Clinical trials in the United States of America -- 8.1.1.1. Early clinical trials in the USA -- 8.1.1.2. Later clinical trials in the USA -- 8.1.2. Clinical trials in Japan -- 8.1.3. Clinical trials in Finland -- 8.1.4. Clinical trials in Sweden -- 8.1.5. Other clinical trials
8.2. Clinical Trials Using Gadolinium Neutron Capture Therapy (GdNCT) -- Chapter 9 Future Perspectives for Boron and Gadolinium Neutron Capture Therapies in Cancer Treatment -- Appendix: The Clinical State of BNCT by US Department of Energy (DOE) as at 1997 -- Bibliography -- Index
Key Features:Bring awareness among the public that the new state-of-the-art cancer treatment known as BNCT and GdNCT will be available in future especially for those suffering from Glioblastoma Multiforme (GBM), where no other treatments are currently available and for them the median survival currently has been 18 months only
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Hosmane, Narayan S Boron And Gadolinium Neutron Capture Therapy For Cancer Treatment Singapore : World Scientific Publishing Company,c2011 9789814338677
主題 Cancer -- Treatment.;Boron-neutron capture therapy.;Boron.;Gadolinium
Electronic books
Alt Author Maguire, John A
Zhu, Yinghuai
Takagaki, Masao
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