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100 1  Woodriff Beirne, Ann 
245 10 Biochemical Imbalances In Disease :|bA Practitioner's 
       Handbook 
264  1 London :|bJessica Kingsley Publishers,|c2010 
264  4 |c©2010 
300    1 online resource (396 pages) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
505 0  FRONT COVER -- A Practitioner's Handbook: Biochemical 
       Imbalances in Disease -- CONTENTS -- Foreword -- Chapter 1
       The Healthcare Futurescape: How Did We Get Here and Where 
       Are We Going? -- 1. Some key shapers of medicine -- 1.1 
       Hippocrates, Galen and humorism -- 1.2 The nineteenth 
       century medical revolution -- 1.3 The twentieth century --
       2. Homeostasis and allostasis -- 2.1 Homeostasis -- 2.2 
       Allostasis -- 3. Functional medicine (FM) -- 3.1 The 
       adoption and usage of the FM model among UK nutritional 
       therapists -- 4. The chapters -- Chapter 2 Gastro-
       Intestinal Imbalances -- Part 1 The gastro-intestinal 
       tract - Use and abuse -- 1. Gastro-intestinal imbalances 
       and disease -- 2. Physiological imbalances of the human 
       digestive system -- 2.1 Oral cavity and oesophagus -- 2.2 
       The stomach -- 2.3 The small intestine -- 2.4 The colon --
       3. Microflora supplementation and the human gut -- 4. 
       Diagnostic testing -- Part 2 Functional disorders of the 
       gastro-intestinal tract -- 5. Functional gastro-intestinal
       tract disorders -- 5.1 Irritable bowel syndrome (IBS) -- 
       5.2 Functional abdominal pain (FAP) -- 5.3 Functional 
       bloating (FB) -- 5.4 Functional constipation (FC) -- 
       Chapter 3 Compromised Detoxification -- 1. Introduction --
       2. Sources and routes of entry of toxins -- 3. Biochemical
       pathways of detoxification -- 3.1 Phase I 
       (biotransformation) -- 3.2 Phase II (conjugation) -- 3.3 
       Phase III (transporters) -- 3.4 Metallothioneins -- 4. 
       Factors affecting detoxification processes -- 5. The 
       impact of toxins on nutrients -- 6. Clinical assessment of
       detoxification capacity and the body burden of toxins -- 
       6.1 Tests to consider -- 6.2 Functional tests -- 6.3 
       Genetic tests of detoxification capacity -- 6.4 Assessment
       of toxic exposure or load -- 7. The detoxification 
       programme -- 7.1 New and/or exacerbated symptoms during 
       detoxification 
505 8  7.2 Considerations for the detoxification programme -- 8. 
       The dietary management of detoxification -- 8.1 Aims of a 
       dietary detoxification programme -- 8.2 Protein -- 8.3 
       Carbohydrates -- 8.4 Fats -- 8.5 Dairy -- 8.6 Herbs and 
       spices -- 8.7 Fasting and dietary restriction -- 8.8 Food 
       preparation -- 9. Lifestyle interventions -- 9.1 Exercise 
       -- 9.2 Sauna -- 9.3 Hydrotherapy -- 10. Supplement 
       treatment regimes -- 11. Chelation therapy -- 
       Contraindications of chelating drugs -- 12. Other 
       considerations for successful detoxification -- 13. 
       Compromised detoxification and chronic disease -- 13.1 
       Examples of common conditions and compromised 
       detoxification -- 14. Conclusion -- Chapter 4 
       Polyunsaturated Fatty Acid (PUFA) Imbalances -- Part 1 The
       health effects of imbalances in PUFA status and metabolism
       -- 1. What are essential fatty acids? -- 2. EFA metabolism
       and eicosanoid synthesis -- 3. Changes in dietary fat 
       intake over time -- 3.1 The n-6:n-3 FA ratio -- 3.2 Trans 
       fats -- 4. Signs and symptoms of PUFA deficiency -- 5. A 
       closer look at some of PUFAs' mechanisms -- 5.1 The role 
       of eicosanoids -- 5.2 Cellular signalling and 
       transcription -- 5.3 Membrane structure and organisation -
       - 6. PUFA modulation of some specific disease processes --
       6.1 Cardiovascular disease (CVD) -- 6.2 Insulin resistance,
       obesity and metabolic syndrome -- 6.3 Cancer -- 6.4 
       Multiple sclerosis (MS) -- 6.5 Other chronic inflammatory 
       disorders -- 7. General recommendations and therapeutic 
       considerations -- 7.1 Patient testing -- 7.2 General 
       dietary recommendations -- 7.3 Supplementation -- 8. 
       Conclusion -- Part 2 PUFAs in the brain -- 9. PUFAs in the
       brain -- 9.1 The role of fatty acids in brain development 
       and function -- 9.2 PUFAs in ADHD, dyslexia and dyspraxia 
       -- 9.3 The role of PUFAs in depression -- 9.5 Cognition, 
       behaviour and mood in the general population 
505 8  9.6 PUFAs and the brain: Conclusion -- Chapter 5 The 
       Metabolic Syndrome: Insulin Resistance, Dysglycaemia and 
       Dyslipidaemia -- 1. Imbalances of affluence -- 1.1 Feast 
       or famine -- 1.2 Xenohormesis -- 2. Physiological 
       responses to food intake -- 2.1 Glycaemic index and 
       glycaemic load -- 2.2 Insulin resistance and blood sugar 
       control -- 3. Consequences of dysglycaemia -- 3.1 Diabetes
       and more -- 3.2 Dyslipidaemia -- 3.3 Hyperinsulinaemia and
       heart disease/CAD -- 3.4 Insulin's effects on IGF-1 and 
       other hormones -- 4. Metabolic syndrome: Contributory 
       factors to consider -- 4.1 The 'chicken and egg' conundrum
       -- 4.2 Insulin and oxidative stress -- 4.3 High risk 
       carbohydrates -- 5. Preventing and reversing insulin 
       resistance and metabolic syndrome -- 5.1 The role of 
       physical activity -- 5.2 The roles of calorie restriction 
       and sirtuins -- 5.3. The role of diet and nutrients -- 6. 
       Specific functional [AQ]nutrient deficiencies and 
       metabolic syndrome -- 6.1 Magnesium -- 6.2 Chromium -- 6.3
       Herbal medicines and phytochemicals -- 7. Are drugs 
       better? -- 8. Summary of prevention and treatment 
       recommendations -- Chapter 6 Compromised Thyroid and 
       Adrenal Function -- Part 1 The Thyroid Gland -- 1. Thyroid
       function -- 1.1 The thyroid gland -- 2. Imbalances in 
       thyroid function -- 2.1 Hyperthyroidism or thyrotoxicosis 
       -- 2.2 Hypothyroidism or myxoedema -- 3. Diagnosis of 
       thyroid function problems -- 3.1 Blood tests for thyroid 
       dysfunction -- 3.2 Radioactive iodine uptake (RIU) -- 3.3 
       Urine hormone assays for thyroid function -- 3.4 
       Functional tests -- 4. Conventional treatment approaches 
       for thyroid conditions -- 4.1 Hyperthyroidism -- 4.2 
       Hypothyroidism -- 4.3 Subclinical (mild) hypothyroidism --
       4.4 Combination treatment -- 5. Issues in the standard 
       approach to diagnosis and management of hypothyroidism -- 
       5.1 Interpreting thyroid function tests 
505 8  5.3 Dissatisfaction with thyroxine therapy -- 6. Thyroid 
       function and other conditions -- 6.1 Pregnancy -- 6.2 Non-
       thyroidal illness or euthyroid sick syndrome (ESS) -- 6.3 
       Other related conditions -- Part 2 - The Adrenals -- Part 
       2 The Adrenals -- 7. Adrenal function -- 7.1 The adrenal 
       glands -- 7.2 Functions of cortisol -- 7.3 Cortisol 
       production -- 8. Imbalances in adrenal function -- 8.1 
       Adrenal fatigue -- 9. Tests for adrenal function -- 9.1 
       Blood tests -- 9.2 Adrenal stress index test (ASI) -- 10. 
       Links between thyroid function and adrenal fatigue -- 11. 
       Nutritional support for the modulation of thyroid and 
       adrenal function -- 11.1 Overall nutritional approach -- 
       11.2 Specific dietary actions for thyroid function -- 11.3
       Nutritional supplements for adrenal function - use and 
       cautions -- 11.4 Herbal medicine -- 11.5 Additional 
       support for thyroid and adrenal function -- Chapter 7 Sex 
       Hormone Imbalances -- 1. The environment, hormonal and 
       developmental health -- 1.1 Endocrine disruptors -- 1.2 
       Obesogens -- 2. Conceptual frameworks for viewing hormonal
       health -- 2.1 Systems Biology -- 2.2 Allostasis -- 2.3 
       Resilience theory -- 2.4 Moving towards 'ease' -- 3. Sex 
       hormones -- 3.1 Synthesis of steroid hormones -- 3.2 
       Oestrogen - not just one hormone -- 3.3 Oestrogen 
       dominance -- 4. Functional processes involved in the safe 
       management of oestrogen and other hormones -- 4.1 
       Detoxification (digestion and absorption) -- 4.2 Phase I 
       detoxification of sex hormones -- 4.3 Phase II 
       detoxification of sex hormones -- 4.4 Transport and 
       binding of oestrogen -- 4.5 Cholesterol transport -- 5. 
       Immune system health (defence) -- 6. Communication -- 6.1 
       Phytoestrogens -- 6.2 Oestrogen and tryptophan metabolism 
       -- 6.3 Oestrogen and monoamine oxidase -- 7. Mitochondrial
       function - oxidative stress -- 8. Conclusion 
505 8  Chapter 8 Dysregulation of the Immune System: A Gastro-
       Centric Perspective -- 1. Introduction -- 1.1 What is a 
       functional approach to innate immunity? -- 2. Immunology's
       developmental history -- 2.1 Phase 1 -- 2.2 Phase 2 -- 2.3
       Phase 3 -- 3. A review of key immune components -- 3.1 The
       innate immune system -- 3.2 The adaptive immune response -
       - 3.3 Humoral immunity -- 3.4 Secretory IgA (SIgA) -- 4. 
       Developing tolerance -- 4.1 Oral induction of tolerance --
       4.2 Environmental contributors -- 5. Contemporary 
       understanding of microbiota and human immunity -- 5.1 The 
       microbiota and mucins - protection in the gut -- 5.2 
       Biofilms -- 5.3 The microbiome -- 6. Gut and disease 
       association -- 6.1 Leaky gut -- 6.2 Small intestinal 
       bacterial overgrowth (SIBO) -- 7. Manipulating mucosal 
       immunity to manage systemic health -- 7.1 Germ Theory vs 
       Symbiotic Theory -- 7.2 Antibiotics -- 7.3 Probiotics -- 
       7.4 Metagenomics and nutrigenomics -- 8. Clinical 
       application -- 8.1 Examination thoughts -- 8.2 Possible 
       natural therapeutic agents to consider -- Chapter 9 Poor 
       Energy Production and Increased Oxidative Stress -- Part 1
       Oxidation and oxidative stress -- 1. Mitochondrial energy 
       production -- 1.1 Micronutrients in mitochondrial 
       metabolism -- 2. The drawbacks of aerobic energy 
       production -- 2.1 Other sources of endogenous oxidants -- 
       2.2 Environmental sources of reactive oxygen species -- 
       2.3 Oxidative stress and disease -- 2.4 Mitochondria as 
       targets of oxidative injury -- 3. Cycle of oxidative 
       stress -- Part 2Antioxidant defences -- Part 2 Antioxidant
       defences -- 4. Antioxidant defence: An overview -- 4.1 
       Endogenous antioxidants -- 4.2 Micronutrient antioxidants 
       -- 4.3 Antioxidant regeneration -- 5. Therapeutic 
       intervention: Antioxidants in the diet -- 5.1 Rating 
       antioxidant potential of food -- 5.2 Guidelines for 
       improving baseline antioxidant status using foods 
505 8  5.3 Antioxidants: Foods in focus 
520    Biochemical imbalances caused by nutritional deficiencies 
       are a contributory factor in chronic illnesses such as 
       cardiovascular disease, diabetes, auto-immune 
       conditions and cancer. This handbook for practitioners 
       explains how to identify and treat such biochemical 
       imbalances in order to better understand and manage a 
       patient's ill-health 
588    Description based on publisher supplied metadata and other
       sources 
590    Electronic reproduction. Ann Arbor, Michigan : ProQuest 
       Ebook Central, 2020. Available via World Wide Web. Access 
       may be limited to ProQuest Ebook Central affiliated 
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650  0 Diseases -- Etiology.;Holistic medicine 
655  4 Electronic books 
700 1  Ash, Michael 
700 1  Bold, Justine 
700 1  Culp, Michael 
700 1  Hallam, Ada 
700 1  Hanciles, Smita 
700 1  Monro, Jean 
700 1  Mortimore, Denise 
700 1  Muller, Angelette 
700 1  Neil, Kate 
776 08 |iPrint version:|aWoodriff Beirne, Ann|tBiochemical 
       Imbalances In Disease : A Practitioner's Handbook|dLondon 
       : Jessica Kingsley Publishers,c2010|z9781848190337 
856 40 |uhttps://ebookcentral.proquest.com/lib/sinciatw/
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