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作者 Rodriguez, Moses
書名 Multiple Sclerosis
出版項 Cary : Oxford University Press, Incorporated, 2013
©2013
國際標準書號 9780199970193 (electronic bk.)
9780199740468
book jacket
說明 1 online resource (216 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 Contemporary Neurology Ser. ; v.84
Contemporary Neurology Ser
附註 Cover -- Contents -- SECTION 1 PATHOGENESIS -- 1. THE SPECTRUM AND DIAGNOSIS OF MULTIPLE SCLEROSIS -- THE SPECTRUM OF IDIOPATHIC INFLAMMATORY DEMYELINATING DISEASES -- THE DIAGNOSIS OF PROTOTYPICAL MULTIPLE SCLEROSIS -- THE PHASES AND EVOLUTION OF PROTOTYPICAL MULTIPLE SCLEROSIS -- SUMMARY -- 2. THE DIFFERENTIAL DIAGNOSIS OF MULTIPLE SCLEROSIS -- OTHER IDIOPATHIC INFLAMMATORY DEMYELINATING DISEASES -- NEURO-MYELITIS OPTICA SPECTRUM DISORDERS (AQUAPORINOPATHIES) -- NON-IDIOPATHIC INFLAMMATORY DEMYELINATING DISEASES CNS SYNDROMES THAT MIMIC MULTIPLE SCLEROSIS -- SUMMARY -- 3. THE EPIDEMIOLOGY OF MULTIPLE SCLEROSIS, GENETICS, AND ENVIRONMENT -- EPIDEMIOLOGY OF MULTIPLE SCLEROSIS: A COMPLEX DISEASE -- GENETICS OF MULTIPLE SCLEROSIS -- ENVIRONMENTAL RISK FACTORS IN MULTIPLE SCLEROSIS -- SUMMARY -- 4. THE ROLE OF MAGNETIC RESONANCE IMAGING IN MULTIPLE SCLEROSIS -- INTRODUCTION -- CONVENTIONAL MRI IN THE CLINIC: COMMONLY USED SEQUENCES AND APPLICATIONS -- MRI IN THE DIAGNOSTIC CRITERIA OF MULTIPLE SCLEROSIS -- THE ROLE OF MRI IN PROGNOSIS OF CLINICALLY ISOLATED SYNDROME -- RADIOLOGICALLY ISOLATED SYNDROME -- THE ROLE OF MRI IN TREATMENT DECISIONS -- SPECIAL DIAGNOSTIC CONSIDERATIONS: MRI IN TUMEFACTIVE DEMYELINATION -- ADVANCED MRI TECHNIQUES -- MRI IN NON-MS DEMYELINATING DISEASES -- SUMMARY -- 5. NEUROPATHOLOGY: CLUES TO PATHOGENESIS -- TRADITIONAL CLASSIFICATION OF INFLAMMATORY DEMYELINATING PATHOLOGY -- NEUROPATHOLOGY OF MS: ESTABLISHED CLASSIFICATION SYSTEM -- NEW CLASSIFICATION SYSTEM -- SUMMARY -- 6. WHAT HAS IMMUNOLOGY TAUGHT US ABOUT MULTIPLE SCLEROSIS? -- INTRODUCTION -- FUNDAMENTAL QUESTION REGARDING THE IMMUNOLOGY OF MULTIPLE SCLEROSIS -- IS MULTIPLE SCLEROSIS AN AUTOIMMUNE DISEASE? -- ROLE OF CYTOKINES AS SURROGATES FOR EXACERBATIONS OR PROGRESSION -- ROLE OF CHEMOKINES IN MULTIPLE SCLEROSIS -- ROLE OF PROTEINASES IN DISEASE PROGRESSION
PERSISTENT VIRUS INFECTION AS A CAUSE OF MULTIPLE SCLEROSIS? -- NATURAL KILLER CELLS -- CSF, IGG, AND OLIGOCLONAL BANDS -- IMMUNOGLOBULINS AS A HINDRANCE TO OLIGODENDROCYTE PROGENITOR DIFFERENTIATION AND REMYELINATION -- B CELLS AS ANTIGEN-PRESENTING CELLS -- TEARS AS A SOURCE OF OLIGOCLONAL IGG IN MULTIPLE SCLEROSIS PATIENTS -- ROLE OF CD4[sup(+)] T CELLS AS INITIATORS OF DISEASE VERSUS EFFECTORS IN DESTRUCTION OF MYELIN -- SUMMARY -- 7. NEURAL DEGENERATION AND POTENTIAL NOVEL TREATMENTS -- INTRODUCTION -- AXONAL LOSS IN NORMAL-APPEARING WHITE MATTER -- RELATIONSHIP BETWEEN AXONAL TRANSECTION AND INFLAMMATION -- NEURONAL AND AXONAL DEATH -- GRAY MATTER INVOLVEMENT IN MULTIPLE SCLEROSIS -- BIPHASIC DISEASE: INFLAMMATORY DEMYELINATION FOLLOWED BY AXONAL PATHOLOGY -- WHY DO NEURONS AND AXONS NOT REGENERATE IN MULTIPLE SCLEROSIS? -- DEMYELINATION WITHIN DEEP GRAY MATTER STRUCTURE -- WHAT IS THE MECHANISM THAT INJURES AXONS AND NEURONS? -- DOES INFLAMMATION CONTRIBUTE TO NEURONAL AND AXONAL DEATH? -- LOWER MOTOR NEURON LOSS OCCURS IN MULTIPLE SCLEROSIS -- SUMMARY -- SECTION 2 TREATMENT -- 8. TREATMENT OF ACUTE EXACERBATIONS OF MULTIPLE SCLEROSIS -- INTRODUCTION -- SHOULD ALL MULTIPLE SCLEROSIS ATTACKS BE TREATED? -- TREATMENT MODALITIES TO ADDRESS MULTIPLE SCLEROSIS RELAPSES: STEROIDS -- TREATING STEROID-UNRESPONSIVE ATTACKS: PLASMAPHERESIS -- TREATMENT OF FULMINANT MULTIPLE SCLEROSIS ATTACKS -- SUMMARY -- 9. DISEASE-MODIFYING THERAPIES IN MULTIPLE SCLEROSIS -- ASSESSING MAGNITUDE OF TREATMENT EFFECT -- USE OF DISEASE-MODIFYING AGENTS IN CLINICALLY ISOLATED SYNDROME -- ALTERING THE COURSE OF RELAPSING-REMITTING MULTIPLE SCLEROSIS -- ALTERING THE COURSE OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS -- THERAPY OF PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS -- SUMMARY -- 10. MANAGING SYMPTOMS OF MULTIPLE SCLEROSIS
THE INTERACTIVE MATRIX OF SYMPTOMATIC MULTIPLE SCLEROSIS THERAPY -- THE CORE OF SYMPTOMATIC MULTIPLE SCLEROSIS THERAPY -- MOTOR DISABILITY -- PAIN AND PAROXYSMAL SYMPTOM-RELATED DISABILITY -- AUTONOMIC DISABILITY -- COGNITIVE AND BEHAVIORAL DISABILITY -- SUMMARY -- 11. FUTURE DISEASE-MODIFYING TREATMENT APPROACHES IN MULTIPLE SCLEROSIS -- CURRENT TREATMENT OUTLOOK -- ANTICIPATED CLINICAL TRIALS -- SUMMARY -- 12. TREATMENT TO PROMOTE REMYELINATION -- MORPHOLOGICAL FEATURES OF CNS REMYELINATION -- OLIGODENDROCYTE REMYELINATION IN MULTIPLE SCLEROSIS -- SCHWANN CELL REMYELINATION IN MULTIPLE SCLEROSIS -- EXPERIMENTAL MODELS OF REMYELINATION -- ROLE OF INFLAMMATION IN REMYELINATION -- CELLULAR BASIS OF REMYELINATION -- WHY DOES REMYELINATION FAIL IN MULTIPLE SCLEROSIS? -- CAN THE IMMUNE SYSTEM BE HARNESSED TO ENHANCE REMYELINATION? -- SUMMARY -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W -- Y
This latest edition to the 'Contemporary Neurology Series' will fill one of the few remaining 'neurologic gaps' within the Series. 'Multiple Sclerosis,' written solely by Moses Rodriguez, Orhun Kantarci and Istvan Pirko of the Mayo Clinic in Rochester, MN offers proven, effective treatments for specific presentations and symptoms of multiple sclerosis along with a pathophysiological explanation of why they work. It bridges a needed gap between overly simplistic therapy manuals and overly conceptual basic science texts that focus more on animal models than actual human disease
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Rodriguez, Moses Multiple Sclerosis Cary : Oxford University Press, Incorporated,c2013 9780199740468
主題 Multiple Sclerosis
Electronic books
Alt Author Kantarci, Orhun H
Pirko, Istvan
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