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作者 Popescu, Maria A
書名 Drug Delivery
出版項 Hauppauge : Nova Science Publishers, Incorporated, 2011
©2011
國際標準書號 9781620815502 (electronic bk.)
9781613245385
book jacket
說明 1 online resource (236 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 Biotechnology in Agriculture, Industry and Medicine
Biotechnology in Agriculture, Industry and Medicine
附註 Intro -- DRUG DELIVERY -- DRUG DELIVERY -- Library of Congress Cataloging-in-Publication Data -- CONTENTS -- PREFACE -- Chapter 1 THE INFLUENCE OF PARTICLE PHYSICOCHEMICAL PROPERTIES ON DELIVERY OF DRUGS BY DRY POWDER INHALERS TO THE LUNG -- Abstract -- Abbreviations -- 1. Introduction -- 2. Anatomy and Physiology of the Lung -- 3. Dry Powder Inhalers -- 3.1. DPI Particle Size -- 3.1.1. Aerodynamic Diameter -- 3.1.2. Mass Median Aerodynamic Diameter (MMAD) -- 3.1.3. Geometric Standard Deviation (GSD) -- 3.1.4. Fine Particle Fraction (FPF, Respirable Fraction) -- 3.1.5. The Effect of Aerosol Particle Size on Aerosol Mixing, Dispersion, and Inhalation Performance -- 3.2. Flow Properties -- 3.3. Particle Shape -- 3.4. Particle Surface Texture -- 3.4.1. Particle Surface Smoothness -- 3.4.2. Particle Surface Roughness -- 3.5. DPI Fine Particles Additives and Ternary Components -- 3.6. Surface Area -- 3.7. Surface Energy -- 3.8. Interaction Forces: Conhesion-Adheison Balance (CAB) -- 3.9. Particle Density -- 4. Blending -- Conclusion -- References -- Chapter 2 PHARMACEUTICAL DOSAGE FORMS: PAST, PRESENT, FUTURE -- Abstract -- 1. Introduction -- 1.1. Drug Delivery, Pharmaceutical Dosage Form, and Formulation -- 1.2. Pharmaceutical Dosage Forms -- 1.2.1. Classification Based on Physical State -- 1.2.2. Classification Based on Route of Administration -- 1.2.3. Dosage Forms -- Miscellaneous Dosage Forms -- 1.3. Emerging Technologies in Dosage Form -- 1.3.1. Modification of Available Dosage Forms -- 1.3.2. Parenteral Route of Administration -- 1.3.3. Transdermal Drug Delivery -- 1.3.4. Biopharmaceuticals -- Conclusion -- Acknowledgments -- References -- Chapter 3 DRUG DELIVERY THROUGH MULTIFUNCTIONAL POLYMERIC NANOPARTICLES -- Abstract -- 1. Introduction -- 2. Liposome-Based Delivery Systems -- 3. Microparticles/Nanoparticles as Carrier Systems
4. Targeting of the Nanoparticles -- 4.1. Passive Targeting -- 4.2. Active Targeting -- 5. Long Circulating Nanoparticles -- 6. Versatility of Polymeric Nanoparticles -- 7. Combination of Antiangiogenic and Cytotoxic Drugs -- 8. Targeted Drug and Gene Delivery Using Multifunctional Nanoparticles -- 9. Combination of Si-RNA and Chemotherapeutic Drugs into Drug Carriers -- 10. Imaging and Photothermal Therapy -- 11. Dendrimers -- Challenges, Advantages and Future Prospects -- Acknowledgments -- References -- Chapter 4 TARGETED LIPOSOMAL-BASED CHEMOTHERAPEUTICS -- Abstract -- Introduction -- Liposomes -- Targeted Liposomes -- Liposomes with Multiple Functionalities -- Conclusion -- Acknowledgments -- References -- Chapter 5 ERYTHROCYTES AS PHARMACOLOGICAL CARRIERS FOR CORTICOSTEROIDS AND OTHER DRUGS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES -- Abstract -- Introduction -- Conventional and Non-Systemic Corticosteroids -- Autologous Red Blood Cells as Carriers for Drugs -- Administration of Corticosteroid-Loaded RBCs in Patients with IBDs -- Future Prospects -- Conclusion -- Acknowledgments -- References -- Chapter 6 RECOLLECTIONS OF 45 YEARS IN RESEARCH: FROM PROTEIN CHEMISTRY TO POLYMERIC DRUGS TO THE EPR EFFECT IN CANCER THERAPY -- Abstract -- 1. Bon Voyage: Passage to the Macromolecular WORLD and Protein Chemistry -- 2. Back to Sendai and the World of Antibiotics -- 3. On to the United States: Work at Chilren's Research Foundation and Harvard Medical School -- 4. Kumamoto University in Kyushu, Japan -- 5. SMANCS in Clinics and Beyond: The Discovery of the EPR Effect -- 6. The Power of Intraarterial Injection of the Polymeric Drug SMANCSs/Lipiodol -- 7. Back to the Basics in Infection, Inflammation, and Cancer: The Roles of Proteases, Reactive Oxygen Species (ROS), and Reactive Nitrogen Species (RNS) in Pathogenesis
7a. Microbial Disease in the Absence of Microorganisms: Microbial Proteases as Pathogens -- 7b. Microbial Disease in the Absence of Microorganisms: Endogenous Free Radicals as Pathogens -- 8. Clarifying Details of the Epr Effect: A Universal Solid Tumor-Targeting Principle of Macromolecular Anticancer Agents -- 9. Factors Facilitating the EPR Effect -- 10. Further Enhancement of the EPR Effect -- 11. SMA as a Versatile Micelle-Forming Agent -- 12. Protein Drugs, Then and Now -- Acknowledgments -- References -- Chapter 7 A NOVEL TRANSDERMAL DRUG DELIVERY SYSTEM MEDIATED BY ARGININE-RICH INTRACELLULAR DELIVERY PEPTIDES -- Abstract -- Abbreviations -- Introduction -- Materials and Methods -- Transdermal Delivery Assay -- Fluorescent and Confocal Microscopy -- Cytotoxicity of AID Peptides -- Results -- Transdermal Delivery of Proteins Noncovalently -- Effect of Chemical Enhancers on the Transdermal Delivery of Proteins -- Cytotoxicity of AID Peptides -- Discussion -- Conclusion -- Acknowledgments -- References -- Chapter 8 STABILITY OF DRUG DELIVERY PLGA NANOPARTICLES: CALORIMERTRIC APPROACH -- Abstract -- Introduction -- Methods -- Preparation of the Nanoparticles -- Colloidal Characteristics of Particles -- Results -- Discussion -- Acknowledgments -- References -- INDEX
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Popescu, Maria A. Drug Delivery Hauppauge : Nova Science Publishers, Incorporated,c2011 9781613245385
主題 Drug delivery systems
Electronic books
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