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作者 Shah, Khalid
書名 Stem Cell Therapeutics for Cancer
出版項 Somerset : John Wiley & Sons, Incorporated, 2013
©2013
國際標準書號 9781118660331 (electronic bk.)
9781118282427
book jacket
版本 1st ed
說明 1 online resource (354 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
附註 Intro -- Stem Cell Therapeutics for Cancer -- Copyright -- Contents -- Contributors -- Preface -- Section 1 Introduction -- Chapter 1 Stem Cell Sources and Their Potential for Cancer Therapeutics -- Introduction -- Adult Stem Cells -- Prospects and Caveats on the Way to the Clinics -- References -- Section 2 Migration and Fate of Stem Cells -- Chapter 2 The Role of CXCR4 as a Mediator of Glioma-Tropic Neural Precursor Cell Migration -- Introduction -- CXCR4 -- CXCR4 and NSC -- Conclusion -- References -- Chapter 3 Tumor Tropism of Mesenchymal Stem Cells -- Introduction -- Homing of MSC to Tumors -- GPCR in MSC Migration -- Activation of MSC Migration by Cytokines and Growth Factors -- Role of MMPs in MSC Migration -- Crosstalk Between MMP-1/PAR-1 Axes with Other Signaling Pathway -- Concluding Remarks -- Acknowledgements -- References -- Section 3 Stem Cell Therapy in Brain Cancer -- Chapter 4 Stem Cell-Mediated TRAIL Therapy for Highly Aggressive Brain Tumors -- Introduction -- Transplantation Route and Fate of Stem Cells -- Genetic Modification of SC -- Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -- Stem cell-mediated delivery of TRAIL -- Stem Cell-Mediated Delivery of TRAIL in Clinically Relevant Mouse Tumor Models -- Resistance to TRAIL and Combination Therapies -- Imaging of Death-Receptor Expression Levels Identifies Modulators of TRAIL Sensitivity -- Combination of MS-275 and Stem Cell-Delivered TRAIL Reveals Efficacy in TRAIL-Resistant GBMs in Vivo -- Conclusions and Perspectives -- References -- Chapter 5 Stem Cell-Mediated Prodrug Gene Therapy of High-Grade Brain Tumors -- Introduction -- Enzymes and Prodrugs in GDEPT for Cancer Treatment -- Classification of Brain Tumors -- Source of Mesenchymal Stem Cells for Therapeutic Use -- Stem Cell-Mediated Prodrug Gene Therapy for Glioblastoma
Stem Cell-Driven Cytosine Deaminase/5-FC System -- Stem Cell-Driven Herpes simplex virus Thymidine Kinase/Ganciclovir System -- Stem Cell-Driven Rabbit Carboxylesterase/ CPT-11 System -- Stem Cell-Driven Therapeutic Cytokines and Proapoptotic Genes -- Conclusions -- Acknowledgements -- References -- Chapter 6 Role of Naïve Cord Blood Stem Cells in Glioma Therapy -- Introduction -- Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells ( hUCBSC) -- Role of hUCBSC in Glioma Therapy -- Future Insights on Cord Blood Stem Cell Therapy -- Acknowledgements -- References -- Chapter 7 Stem Cell-Based Antiangiogenic Therapies for Brain Tumors -- Introduction -- Stem Cell-Based Antiangiogenic Therapies -- Conclusions and Perspectives -- References -- Chapter 8 Treatment of Metastatic Neuroblastoma with Mesenchymal Stem Cell-Based Oncolytic Virotherapy -- Neuroblastoma -- Oncolytic Virotherapy -- Mesenchymal Stem Cell and Oncolytic Virotherapy -- Conclusions and Perspectives -- References -- Section 4 Stem Cell Therapy in Other Cancer Types -- Chapter 9 Umbilical Cord Matrix Stem Cells for Cytotherapy of Breast Cancer -- Introduction -- MSC in Cancer Cytotherapy -- Characteristics of UCMSC -- UCMSC in cancer therapy -- UCMSC Therapy in Breast Cancers -- Future Studies -- Conclusion -- Acknowledgements -- References -- Chapter 10 Mesenchymal Stromal Cells as Effective Tumor Antigen-Presenting Cells in Cancer Therapeutics -- Introduction -- Medical Use of MSC in Treating Alloimmune Complications in the Context of GVHD in Non-Self-HSC-Transplanted Patients -- Immune Plasticity of MSC -- MSC and Cancer -- Conclusion -- Acknowledgements -- References -- Chapter 11 Diagnostic and Therapeutic Mesenchymal Stem Cells for Breast Cancer Treatment -- Introduction -- MSC Homing and Immune Regulation -- Stem Cells that Have Combined Therapeutic and Diagnostic Functions
Perspectives -- References -- Chapter 12 Genetically Engineered Stem Cell Therapies Targeting Gastrointestinal Malignancy -- Introduction -- Genetic Modifications of Stem Cells to Target Gastrointestinal Malignancy -- Genetically Engineering MSC to Target Gastrointestinal Malignancy: Transgene Products -- Genetically Engineering MSC to Target Gastrointestinal Malignancy: Strategies to Enhance Tumor Selectively -- Choice of Targeting Strategy Must Be Based on Thorough Understanding of Tumor Biology -- Current Limitations of Genetically Engineered Stem Cell Cancer Therapy Targeting Gastrointestinal Malignancy -- Conclusion -- References -- Chapter 13 Mesenchymal Stem Cells in Prostate Cancer: Clinical Opportunities -- Background and Significance -- Pathology of the Tumor Microenvironment: The MSC Connection -- Recruitment of MSC to the Tumor Microenvironment -- MSC in Prostate Cancer: An Update -- Genetically Engineered MSC for the Treatment of Prostate Cancer -- Clinical Prospects -- Acknowledgements -- References -- Chapter 14 Primed Mesenchymal Stromal Cells for Cancer Therapy -- Introduction -- Priming Mesenchymal Stromal Cells with Paclitaxel -- Testing PTX Uptake and Release -- PTX -Uptake /Release Mechanism and Kinetics -- In Vitro Antitumor Proliferation Activity -- Antiangiogenic Properties of MSCPTX -- Capacity of MSC-PTX to Inhibit In Vivo Tumor Growth -- PTX Uptake Released by Stromal Cells from Different Species and Sources -- Conclusions -- References -- Section 5 Combinatorial Stem Cell Therapies -- Chapter 15 MicroRNA Adjuvants in Stem Cell-Based Cancer Therapy -- Introduction -- MicroRNAs: Biogenesis and Function -- MicroRNAs and Cancer -- MicroRNA Adjuvants in Cancer Research -- MicroRNA -21: Target for Combinational Therapy -- MicroRNAs: Regulators of TRAIL-Induced Apoptosis -- Conclusion and Future Perspectives -- References
Chapter 16 Stem Cell-Based Combination Therapies for Cancer: Systemic Delivery of a PI3K/mTOR Inhibitor (PI-103) and Stem Cell-Mediated Delivery of TRAIL in Brain Tumors -- Introduction -- Stem-Cell Based Combination Therapies in GBM -- PI3K Signaling in GBM -- PI3 Kinase Inhibitors -- PI-103 -- PI3K Inhibition and TRAIL -- PI-103 and Stem Cell-Delivered TRAIL -- Concluding Remarks -- References -- Chapter 17 The Efficacy of Clinically Approved Agents with Stem Cell-Delivered Therapeutics for Cancer Therapy -- Introduction -- Conventional Therapy for Cancer and Glioblastoma -- Combining Stem Cell Delivery of TRAIL with Chemotherapeutic Temozolomide -- Combining Stem Cell Delivery of TRAIL with Radiation Therapy -- Other Candidates to Combine with Stem Cell Delivery of Proapoptotic Molecule -- Conclusions -- References -- Section 6 Tracking Stem Cells and Stem Cell-Based Therapeutics -- Chapter 18 Imaging Migration and Fate of Stem Cells in Experimental Models of Cancer -- Introduction -- Optical Imaging as an Efficient Method for Imaging and Tracking Fate of Stem Cells -- Conclusion -- References -- Chapter 19 Multifunctional Molecules for Interrogating Stem Cell-Based Therapeutics -- Introduction -- Conclusions -- References -- Chapter 20 Tracking Cancer-Targeted MSC with PET Imaging -- Introduction -- Principles of PET Imaging -- Labeling Strategies for PET Imaging -- Application of MSC Imaging with PET -- Limitations -- Future Perspectives -- Conclusions -- References -- Index -- Supplemental Images
A single-source reference on the hot topic of stem cell therapeutics for cancer This work offers a thorough, cohesive look at the state of the art of stem cell therapeutics for cancer, with an emphasis on the unique application of mesenchymal stem cells (MSC) and MSC-like cells as gene-delivery agents in cancer treatment. Edited by a leader in the field, the book brings together a wealth of information from this growing area of research, highlighting topics critical to the success of future therapies, including stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Organized in sections according to disease types, the chapters explore the engineering of specific stem cell types with the protein of interest as well as results from studies of animal models and early-phase clinical trials. The use of cutting-edge molecular imaging techniques for a variety of tumor types is also integrated into the text. Coverage includes: An overview of stem cell types and their fate in models of cancer Stem cell monotherapy in brain cancers, lung cancers, breast cancers, and other malignancies The use of stem cells in combination with other therapies Diagnostic tracking of both stem cells and therapeutic molecules in cancer treatments Possible adverse effects of MSC on tumors, including details on tumor-initiating cells in certain tumor types Clear, concise, and up to date, Stem Cell Therapeutics for Cancer is a must-have resource for scientists and clinicians in stem cell research, cancer therapies, novel drug development, and molecular imaging, and for anyone wishing to learn about the unprecedented potential of stem cell therapeutics for various cancer types
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Shah, Khalid Stem Cell Therapeutics for Cancer Somerset : John Wiley & Sons, Incorporated,c2013 9781118282427
主題 Cellular therapy.;Cell transplantation.;Cancer -- Treatment
Electronic books
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