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作者 Turner, Cortney Ann
書名 Prevention of stereotyped behavior by environmental enrichment: Neurobiological mechanisms
國際標準書號 9780496442928
book jacket
說明 120 p
附註 Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3127
Chair: Mark H. Lewis
Thesis (Ph.D.)--University of Florida, 2003
Developmental, neurological, genetic, and psychiatric disorders exhibit stereotyped behaviors (abnormal, repetitive motor behaviors). Furthermore, animal models have been developed to study the neurobiology of stereotyped behaviors by genetic, pharmacological, or environmental manipulation. The current studies examined the relationship between environmental context and stereotyped behaviors
The first study evaluated whether the effects of environmental enrichment on the development of stereotyped behavior in deer mice were associated with alterations in neuronal metabolic activity. Neuronal metabolic activity was assessed by cytochrome oxidase (CO) histochemistry. Results showed that the prevention of stereotyped behaviors by environmental enrichment was associated with increased neuronal metabolic activity in the motor areas (e.g., motor cortex, striatum), but not in areas involved in learning and memory or emotionality
The second study evaluated whether the effects of environmental enrichment on the development of stereotyped behavior in deer mice were associated with alterations in dendritic morphology. Dendritic spine density and arborization were assessed in layer V pyramidal neurons of the motor cortex, medium spiny neurons of the dorsolateral striatum, and granule cells of the dentate gyrus (control area) using Golgi-Cox histochemistry. Results suggest that the enrichment-related prevention of stereotyped behavior was associated with increased dendritic spine density in the motor areas, but not the control region
The third study evaluated whether the effects of environmental enrichment on the development of stereotyped behavior in deer mice were associated with alterations in neurotrophin levels. The motor cortex, striatum, and hippocampus were dissected, and protein levels of brain-derived neurotrophin factor (BDNF) and nerve growth factor (NGF) were analyzed using Promega ELISA kits. Results indicate that the enrichment-related prevention of stereotyped behavior in deer mice was associated with increased BDNF in the striatum. No other differences were found in other areas, or for NGF in any of the regions
The results of these studies indicate that the prevention of stereotyped behaviors by environmental enrichment in deer mice is associated with increased neuronal metabolic activity, dendritic morphology, and neurotrophin expression in motor areas. These studies shed light on the neurobiological mechanisms responsible for the prevention of stereotyped behaviors in animals
School code: 0070
DDC
Host Item Dissertation Abstracts International 64-07B
主題 Biology, Neuroscience
0317
Alt Author University of Florida
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