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作者 Jacob, Claus
書名 Redox Signaling and Regulation in Biology and Medicine
出版項 Hoboken : John Wiley & Sons, Incorporated, 2009
©2009
國際標準書號 9783527627592 (electronic bk.)
9783527319251
book jacket
版本 1st ed
說明 1 online resource (517 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
附註 Redox Signaling and Regulation in Biology and Medicine -- Contents -- Preface -- The Editors -- List of Authors -- 1 Introduction -- 2 Biological Systems Relevant for Redox Signaling and Control -- 2.1 Introduction -- 2.2 Reactive Oxygen Species -- 2.2.1 The Superoxide Radical -- 2.2.1.1 Generation of the Superoxide Radical -- 2.2.1.2 The Superoxide Radical as a Redox Signal -- 2.2.1.3 Decomposition of the Superoxide Radical -- 2.2.2 Hydrogen Peroxide -- 2.2.2.1 Generation of Hydrogen Peroxide -- 2.2.2.2 Mechanisms of Hydrogen Peroxide Signaling -- 2.2.2.3 Decomposition of Hydrogen Peroxide -- 2.3 Reactive Nitrogen Species -- 2.3.1 Nitric Oxide -- 2.3.1.1 Generation of Nitric Oxide -- 2.3.1.2 Mechanisms of Nitric Oxide Signaling -- 2.3.1.3 Decomposition of Nitric Oxide -- 2.3.2 Peroxynitrite and Reactive Nitrogen Species -- 2.3.2.1 Generation of Peroxynitrite and Other Important Reactive Nitrogen Species -- 2.3.2.2 Mechanisms of Peroxynitrite- and Reactive Nitrogen Species-Mediated Redox Signaling -- 2.4 Lipid Peroxidation Products -- 2.4.1 Generation of Lipid Peroxidation Products -- 2.4.2 Mechanisms of Signaling with Lipid Peroxidation Products -- 2.4.3 Decomposition of Lipid Peroxides -- 2.5 Conclusions -- References -- 3 Cellular Generation of Oxidants: Relation to Oxidative Stress -- 3.1 Introduction -- 3.2 Molecular Oxygen and Reactive Oxygen Species: Biochemical Relations and Endogenous Sources -- 3.2.1 Endogenous Sources of Superoxide and Superoxide-Derived Reactive Oxygen Species -- 3.2.2 Singlet Oxygen -- 3.2.3 "Secondary" Reactive Oxygen Species Generated in Radical Chain Reactions -- 3.3 Generation of Oxidative Stress Under the Influence of Xenobiotics and Stressful Stimuli -- 3.3.1 Quinones and Other Redox Cyclers -- 3.3.2 Antioxidant Depletion by Alkylation: Acetaminophen Toxicity -- 3.3.3 Ultraviolet Radiation
3.3.4 Ultrafine or Nanoparticles -- References -- 4 The Chemical Basis of Biological Redox Control -- 4.1 Introduction -- 4.2 Forms of Elemental Oxygen as Reactive Oxygen Species -- 4.2.1 Reactive Oxygen Species and Related Cellular Oxidants -- 4.2.2 Singlet Oxygen (1O2) -- 4.2.3 Ozone (O3) -- 4.3 Reduced, Yet Oxidizing: the Chemistry of Oxygen in Oxidation States between 0 and -2 -- 4.3.1 Superoxide Radicals (O2 ˙¯ ) -- 4.3.2 The Superoxide to Peroxide Conversion as a Key Event in Redox Signaling -- 4.3.3 Hydrogen Peroxide (H2O2) -- 4.3.4 Hydroxyl Radicals (HO·) -- 4.3.5 Enzymatic Reduction of Hydrogen Peroxide by Peroxiredoxins, Catalase and Glutathione Peroxidase -- 4.4 The Role of Labile Metal Ions in Oxidative Stress -- 4.5 Follow-on Species Generated by Chemical Interactions of Reactive Oxygen Species -- 4.5.1 Hypochlorous Acid (HOCl) -- 4.5.2 Peroxynitrite (ONOO¯ ) -- 4.6 Nitrogen Monoxide and Reactive Nitrogen Species -- 4.6.1 Reactive Nitrogen Species -- 4.6.2 S-Nitrosothiols -- 4.7 Sulfur as a Prime Target of Oxidative Stress -- 4.7.1 Thiol Groups in Peptides and Proteins -- 4.7.2 The Concept of Reactive Sulfur Species -- 4.7.3 Sulfur-Centered Radicals -- 4.7.4 Disulfide-S-Oxides (RS(O)xSR') -- 4.7.5 Sulfenic and Sulfinic Acids (RSOH and RS(O)OH) -- 4.7.6 Oxidation of Methionine: Sulfoxides (RS(O)R) and Sulfones (RS(O)2R') -- 4.7.7 S-Thiolation as Chemical Protection -- 4.7.8 Oxidation of Disulfides -- 4.8 A Brief Overview of Hydroxylation and Nitration Reactions -- 4.8.1 Hydroxylation and Nitration of Aromatic Residues -- 4.8.2 Fatty Acid Chemistry -- 4.9 Conclusion -- References -- 5 Protein Glutathiolation -- 5.1 Introduction: Glutathione - From Antioxidant to Redox Signal -- 5.2 Glutathiolation -- 5.3 Mechanisms of Glutathiolation -- 5.3.1 ROS-Dependent Glutathiolation by Thiol/Disulfide Exchange Reactions
5.3.2 ROS-Dependent Glutathiolation via Sulfenic Acid -- 5.3.3 ROS-Dependent Glutathiolation by Radical Reactions -- 5.3.4 ROS-Independent Glutathiolation -- 5.4 Toxicological Aspects of Glutathiolation -- 5.5 Mechanisms of Deglutathiolation -- 5.6 Enzymes Implicated in Glutathiolation -- 5.7 Specificity of Glutathiolation -- 5.8 Genetic Factors Affecting Glutathiolation -- 5.8.1 Mouse Beta-Globin -- 5.8.2 Glucose-6-Phosphate Dehydrogenase Mutations -- 5.8.3 Glutathione S-Transferase Mutations -- 5.9 Future Perspectives -- References -- 6 Structure and Function of the Human Peroxiredoxin-Based Antioxidant System: the Interplay between Peroxiredoxins, Thioredoxins, Thioredoxin Reductases, Sulfiredoxins and Sestrins -- 6.1 Introduction -- 6.2 Peroxiredoxins -- 6.3 Thioredoxins -- 6.4 Thioredoxin Reductases -- 6.5 Sulfiredoxin and Sestrins -- 6.6 Regulation of the Expression and Activity of the Peroxiredoxin-Based System Enzymes -- 6.7 Cell Signaling and the Peroxiredoxin-Based System: Regulation of Transcription Factors, Cell Cycle and Apoptosis -- 6.8 Peroxiredoxin-Based System in Cells and Organs of the Body -- 6.9 Summary -- References -- 7 Hydrogen Peroxide and Cysteine Protein Signaling Pathways -- 7.1 Introduction -- 7.2 Hydrogen Peroxide Production in Cells and Tissues -- 7.3 Sources and Concentrations of Hydrogen Peroxide -- 7.4 Hydrogen Peroxide and the Formation of Secondary Oxidants such as Peroxynitrite -- 7.5 Exogenous Hydrogen Peroxide as an Experimental Tool -- 7.6 Hydrogen Peroxide Sensing and Cysteine Sensors -- 7.7 Low Molecular Weight Oxidized Thiols and S-Thiolated Protein Adducts -- 7.8 Protein Thiol Modifications -- 7.9 Protein Regulation via Sulfination-Dependent Proteolysis -- References -- 8 Protein Tyrosine Phosphatases as Mediators of Redox Signaling -- 8.1 Introduction -- 8.2 Protein Tyrosine Phosphatases
8.3 Protein Tyrosine Phosphatases are Sensitive to Oxidation -- 8.4 Allosteric Regulation of Receptor Protein Tyrosine Phosphatases by Oxidation -- 8.5 Activation of Sdp1 by Oxidation -- 8.6 Physiological Relevance of Protein Tyrosine Phosphatase Oxidation -- 8.7 Conclusions -- References -- 9 Hypoxia-Induced Gene Regulation through Hypoxia Inducible Factor-1α -- 9.1 Introduction -- 9.2 The Proteins and Mechanism -- 9.3 Hypoxia Inducible Factor Target Genes -- 9.4 Non-Hypoxia-Induced Activation of Hypoxia Inducible Factor -- 9.5 Diseases Involving Hypoxia Inducible Factor -- 9.6 The Promise of Hypoxia Inducible Factor-Targeted Therapies -- 9.7 Conclusions -- References -- 10 Eicosanoid-Based Signaling -- 10.1 Introduction -- 10.2 Biosynthesis and Structures of Eicosanoids -- 10.2.1 Lipoxygenases -- 10.2.2 Cyclooxygenases -- 10.2.3 Cytochrome P450 -- 10.3 Signaling by Eicosanoids -- 10.4 Metabolism of Eicosanoids -- 10.5 Summary -- References -- 11 Redox-Controlled Transcription Factors and Gene Expression -- 11.1 Introduction -- 11.2 Redox Signaling and Gene Microarry Data: The Global Picture -- 11.3 The Antioxidant Response Element -- 11.4 The Transcription Factor Nrf2: The Master Regulator of Antioxidant Transcription -- 11.5 The Keap1-Nrf2 Complex: A Sensor for Cellular Stress -- 11.5.1 Reactive Oxygen Species, Reactive Nitrogen Species and Electrophile Sensing by Keap1 -- 11.5.2 Structural Basis for the Sensing Function of the Keap1-Nrf2 Complex -- 11.6 Redox Reactions of Transcription Factors -- 11.6.1 Nuclear Factor kB: Redox Control of the Immune Response -- 11.6.2 Activator Protein 1 (AP-1): Redox Control of Proliferation and Apoptosis -- 11.6.3 The Role of the Nuclear Redox State in Gene Expression -- 11.7 Summary -- References -- 12 Nitric Oxide Regulation in Redox Signaling -- 12.1 Introduction -- 12.2 Nitric Oxide Formation
12.3 Factors Affecting Nitric Oxide Reactivity and Signaling -- 12.3.1 Compartmentalization and Diffusion -- 12.3.2 Interaction with Metal Centers -- 12.3.3 Nitric Oxide Reaction with Free Radicals -- 12.3.3.1 Nitric Oxide and Superoxide -- 12.3.3.2 Peroxynitrite -- 12.3.3.3 Nitrogen Dioxide/Dinitrogen Trioxide -- 12.4 Nitric Oxide Signaling Beyond Soluble Guanylate Cyclase -- 12.4.1 Nitric Oxide and Mitochondria -- 12.4.2 S-Nitrosation -- 12.4.3 Nitrated Lipids -- 12.4.4 3-Nitrotyrosine -- 12.5 Redox Derivatives of Nitric Oxide -- 12.5.1 Nitroxyl Anion -- 12.5.2 Nitrite -- 12.5.3 Nitrite - a Potential Reservoir for Nitric Oxide Bioactivity During Hypoxia -- 12.6 Summary -- References -- 13 Is Hydrogen Sulfide a Regulator of Nitric Oxide Bioavailability in the Vasculature? -- 13.1 Introduction -- 13.2 Reactive Nitrogen Species -- 13.3 Reactive Nitrogen Species in the Heart and Vasculature -- 13.4 Hydrogen Sulfide Biosynthesis -- 13.5 Hydrogen Sulfide Measurement, Catabolism and Removal -- 13.6 Hydrogen Sulfide in the Heart and Vasculature -- 13.7 What is the Evidence for "Crosstalk" between Nitric Oxide and Hydrogen Sulfide -- 13.8 Nitric Oxide/Hydrogen Sulfide and Evidence for the Formation of A Novel Intermediate -- 13.9 Concluding Remarks -- References -- 14 Aspects of Nox/Duox Signaling -- 14.1 Introduction -- 14.2 The Nox/Duox Enzymes (Expression and Domain Structure) -- 14.2.1 NOXO1 and NOXA1 -- 14.3 Mechanism of the Nox/Duox Activation -- 14.3.1 Nox1 -- 14.3.2 Nox3 -- 14.3.3 Nox4 -- 14.3.4 Nox5 -- 14.3.5 Duox -- 14.4 Redox Signaling Activated by NADPH Oxidase -- 14.4.1 Activation of Kinases and Phospholipases -- 14.4.2 Activation of Ion Channels and Calcium Signaling -- 14.4.3 Oxidative Inactivation of Protein Tyrosine Phosphatase -- 14.4.4 Specific Localization of NADPH Oxidase as Mechanism of Activation of Specific Redox Signaling
14.5 Transcription Factors and Gene Expression Regulated by ROS
This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Jacob, Claus Redox Signaling and Regulation in Biology and Medicine Hoboken : John Wiley & Sons, Incorporated,c2009 9783527319251
主題 Oxidation-reduction reaction.;Cellular signal transduction
Electronic books
Alt Author Winyard, Paul G
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