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作者 Riella, Cristian, author
書名 Polycystic kidney disease [electronic resource] / Cristian Riella, Peter G. Czarnecki, Theodore I. Steinman
出版項 [San Rafael, California] : Morgan & Claypool, 2017
國際標準書號 9781615047475 (electronic bk.)
1615047476 (electronic bk.)
9781615047468 print
1615047468
國際標準號碼 10.4199 / C00150ED1V01Y201612ISP073 doi
book jacket
說明 1 online resource (1 PDF (viii, 47 pages)) : illustrations
text rdacontent
electronic isbdmedia
online resource rdacarrier
系列 Colloquium series on integrated systems physiology, 2154-5626 ; # 73
Colloquium series on integrated systems physiology ; # 73. 2154-5626
附註 Part of : Colloquium digital library of life sciences
Includes bibliographical references (pages 35-44)
1. Introduction --
2. Epidemiology --
3. Molecular basis of disease -- 3.1 Genetic basis of disease - - 3.1.1 ADPKD -- 3.2 Molecular basis of PKD --
4. Clinical manifestations -- 4.1 Signs and symptoms -- 4.2 Diagnosis -- 4.2.1 Physical examination findings -- 4.2.2 Laboratory tests -- 4.2.3 Imaging -- 4.2.4 Differential diagnosis --
5. Clinical management of PKD -- 5.1 Pain -- 5.2 Infection -- 5.3 Hematuria -- 5.4 Nephrolithiasis -- 5.5 Hypertension -- 5.5.1 Hypertension in the pediatric population -- 5.6 Hyperlipidemia -- 5.7 Lifestyle modifications -- 5.8 Water intake -- 5.9 Renal replacement therapy and transplantation -- 5.10 Autosomal dominant polycystic kidney disease (ADPKD) and pregnancy -- 5.11 Extrarenal manifestations and complications -- 5.11.1 Polycystic liver disease -- 5.11.2 Intracranial aneurysms (ICA) --
6. Therapies -- 6.1 Therapeutic approaches -- 6.2 Vasopressin and somatostatin receptor and cAMP-dependent signaling -- 6.3 MTOR-pathway -- 6.4 Growth factor and cytokine signaling pathways -- 6.5 Statins -- 6.6 Future directions --
7. Summary and conclusion -- Bibliography -- Author biographies
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Cystic kidney diseases comprise a spectrum of genetic syndromes defined by renal cyst formation and expansion with variable extrarenal manifestations. The most prevalent disorder is the autosomal dominant polycystic kidney disease (ADPKD). It is the most common monogenetic disorder in humans and accounts for 4.4% of end-stage renal disease (ESRD) cases in the U.S. Patients inevitably progress to ESRD and require renal replacement therapy in the form of dialysis or transplantation. Through advancements in genomics and proteomics approaches, novel genes responsible for cystic diseases have been identified, further expanding our understanding of basic mechanisms of disease pathogenesis. The hallmark among all cystic genetic syndromes is the formation and growth of fluid-filled cysts, which originate from tubular epithelia of nephron segments
Cysts are the disease, and treatment strategies are being developed to target prevention or delay of cyst formation and expansion at an early stage, however no such therapy is currently approved. This book reviews important aspects of polycystic kidney diseases, the latest scientific understanding of the diseases and syndromes, along with the therapies being developed
鏈接 Print version: 9781615047468
主題 Polycystic kidney disease
Polycystic Kidney Diseases
Electronic books
Alt Author Czarnecki, Peter G., author
Steinman, Theodore I., author
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