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書名 protein misfolding and disease : principles and protocols / edited by Peter Bross, Niels Gregersen
出版項 Totowa, New Jersey : Humana Press, c2003
國際標準書號 1588290654
book jacket
館藏地 索書號 處理狀態 OPAC 訊息 條碼
 生命科學圖書館  QU55 P9672 2003    在架上    30150100208864
說明 xv, 318 p. : ill. ; 24 cm
系列 Methods in molecular biology ; 232
Methods in molecular biology ; 232
附註 Includes bibliographical reference and index
Protein Misfolding, Aggregation, and Degradation in Disease -- Basic Introduction to In Vivo Protein Folding and Its Defects -- Cystic Fibrosis: Premature Degradation of Mutant Proteins as a Molecular Disease Mechanism -- [alpha]1-Antitrypsin Deficiency: Liver Disease Associated With Retention of a Mutant Secretory Glycoprotein in the Endoplasmic Reticulum -- Parkinson's Disease: [alpha]-Synuclein and Parkin in Protein Aggregation and the Reversal of Unfolded Protein Stress -- Aberrant Protein Folding as the Molecular Basis of Cancer -- Yeast as a Model System to Investigate Protein Conformational Diseases -- Expression of Recombinant Proteins: An Introduction -- Expression of E. coli Systems -- Protein Expression in Yeasts -- Site-Directed Mutagenesis -- Pulse-Chase Labeling Techniques for the Analysis of Protein Maturation and Degradation -- Detection of Aggregates and Protein Inclusions by Staining of Tissues -- Study of Mutant Proteins With Folding Defects in Cultured Patient Cells -- E. coli Expression System for Identifying Folding Mutations of Human Adenosine Deaminase -- Characterization of Overexpressed Mutant Proteins in Mammalian Cells -- Investigation of Unfolded-Protein Response in Cells Expressing Familial Alzheimer's Disease-Linked Presenilin Variants -- Huntingtin Fragments Form Aggresome-Like Inclusion Bodies in Mammalian Cells -- Application of Chemical Chaperones to the Rescue of Folding Defects -- Analysis of Defective Subunit Interactions Using the Two-Hybrid System -- Investigation of Folding and Degradation of In Vitro Synthesized Mutant Proteins in the Cytosol -- Investigation of Folding and Degradation of In Vitro Synthesized Mutant Proteins in Microsomes -- Investigation of Folding and Degradation of In Vitro Synthesized Mutant Proteins in Mitochondria -- Investigation of Folding and Degradation of Mutant Proteins Synthesized in Semipermeabilized Cells
主題 Protein -- pathophysiology -- laboratory manuals
Protein folding -- laboratory manuals
Alt Author Bross, Peter
Gregersen, Niels
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